The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies
Abstract
Background While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear.Aims To review recent structural magnetic resonance imaging (MRI) research findings in MDD while considering the potential influence of key clinical and demographic variables.Method A selective review of all T1-weighted structural MRI studies published between 2000 and 2007 in adult samples of MDD patients.Results Volumetric reductions of the hippocampus, basal ganglia and OFC and SGPFC are consistently found in MDD patients, with more persistent forms of MDD (e.g., multiple episodes or repeated relapses, longer illness duration) being associated with greater impact on regional brain volumes. Gender, medication, stage of illness, and family history all affect the nature of the findings in a regionally specific manner.Limitations Overall, differences between the samples in factors such as illness severity, medication, gender and family history of mental illness makes difficult to identify their confounding effects on the observed neuroanatomical changes. Also, the tracing protocols used for particular brain regions were different amongst the reviewed studies, making difficult to compare their findings.Conclusions The data support the notion that MDD involves pathological alterations of limbic and cortical structures, and that they are generally more apparent in patients with more severe or persistent forms of the illness.
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“Meta-analyses revealed that depressed patients showed large volume reductions in frontal regions, especially in the anterior cingulate and OFC (Koolschijn et al., 2009; Lorenzetti et al., 2009).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Lorenzetti et al., 2009
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Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826
Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews
Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Porter, A. C., Tugwell, P., Moher, D., & Bouter, L. M. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-10 · Cited by 4,374
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
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for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172
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Metadata
- Authors
- Lorenzetti, V., Allen, N. B., Fornito, A., & Yücel, M.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Yücel, Murat
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 117
- Issue
- 1-2
- Pages
- 1-17
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1980508260
- Cited by
- 553
- References
- 91
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 29 · 2020: 37 · 2019: 34 · 2018: 22 · 2017: 42 · 2016: 35 · 2015: 56 · 2014: 43 · 2013: 45 · 2012: 52
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- major depressive disorder, structural brain abnormalities, hippocampal volume, basal ganglia, orbitofrontal cortex, brain atrophy, dysthymia, disease duration, relapse, gender differences, antipsychotic drugs, family history of mental illness, limbic system, cortical structure
- MeSH terms
- Adult, Amygdala, Basal Ganglia, Brain, Major Depressive Disorder, Female, Frontal Lobe, Hippocampus, Humans, Limbic System, Magnetic Resonance Imaging, Male, Severity of Illness Index, Sex Factors, Temporal Lobe, Genetic Predisposition to Disease
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