Val1483Ile Polymorphism in the Fatty Acid Synthase Gene Was Associated with Depressive Symptoms under the Influence of Psychological Stress
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Background To study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated.Method A cross-sectional study was conducted on 177 women (n = 166) and men (n = 15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphism, and confounders as independent variables.Results Under the influence of perceived stress, S/S carriers of the 5-HTTLPR gene showed significantly higher CES-D scores in comparison with L/L+L/S carriers (F = 8.2, standardised β = 0.15, p < 0.05). Regression analysis also confirmed that CES-D scores in participants with Ile/Ile+Val/Ile genotypes of the FASN gene were significantly higher than those with Val/Val genotype (F = 8.4, standardised β = 0.16, p<0.05). In relation to physical features, BMI among participants with S/S genotype of 5-HTTLPR was significantly lower compared with those with L/L+L/S genotypes.Conclusions The Val1483Ile polymorphism in the FASN was associated with depressive symptoms under the influence of psychological stress. The S variant of 5-HTTLPR was related with less obese.
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- H. Tsuboi et al. / Journal of Affective Disorders xxx (2011) xxx -xxx insulin sensitivity in adult white men. Obesity 17, 1755 -1761 (Silver Spring).
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- Authors
- Tsuboi, H., Sakakibara, H., Yamakawa-Kobayashi, K., Tatsumi, A., Inamori, T., Hamamoto, R., Suzuki, A., & Shimoi, K.
- Affiliations
- Kanazawa University (JP)
- Shizuoka University (JP)
- Hamamatsu University (JP)
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 134
- Issue
- 1-3
- Pages
- 448-452
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2029920460
- Cited by
- 10
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2017: 2 · 2015: 1 · 2014: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology, Japan (21500665)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- fatty acid synthase, 5-HTTLPR, depressive symptoms, psychological stress, perceived stress, genetic polymorphism, body mass index, obesity, lipid metabolism, gene-environment interaction
- MeSH terms
- Adult, Alleles, Cross-Sectional Studies, Depression, Depressive Disorder, Female, Genotype, Humans, Isoleucine, Japan, Male, Middle Aged, Obesity, Polymorphism, Genetic, Stress, Psychological, Epidemiologic Studies, Serotonin Plasma Membrane Transport Proteins, Fatty Acid Synthase, Type I, Fatty Acid Synthases
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