CoChat
Sign Up
Cited by 13Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

Does comorbid subthreshold anxiety predict treatment response in depression? Results from a naturalistic cohort study (the CRESCEND study)

Open access
Seo, Ho-Jun, Song, Hoo Rim, Jeong, Seunghee, Kim, Jung-Bum, Lee, Min-Soo, Kim, Jae-Min, Yim, Hyeon Woo, Jun, Tae-Youn·2014·Journal of Affective Disorders
DOI 10.1016/j.jad.2013.09.037
Open this paper in CoChat — free account

Abstract

Objective To investigate whether the anxious depression defined as depression with clinically significant anxiety but not comorbid anxiety disorder predicts poor outcomes of depression treatment in naturalistic clinical setting.Method From nationwide sample of 18 hospitals, 674 patients with moderate to severe depression who completed the DSM-IV-based Structured Clinical Interview (SCID) were recruited. Anxious depression was defined as not having comorbid anxiety disorder by SCID and having a Hamilton Rating Scale for Anxiety (HAM-A) total score ≥ 20. Participants were classified into three groups: anxious depression (N=259), non-anxious depression (N=351), or comorbid anxiety disorder (N=64). Rates of and time to remission and response and changes in scale scores were compared between these groups during 12 weeks treatment with antidepressant interventions freely determined by clinicians.Results No significant differences were observed in the Hamilton Rating Scale for Depression (HAM-D) remission rate and the time to achieve HAM-D remission between anxious and non-anxious depression after adjustment for variables is not equally distributed at baseline. There were also no significant differences in HAM-D and HAM-A response rate and time to responses between two groups. Patients with comorbid anxiety disorder showed less improvement on HAM-D and HAM-A score than did those with anxious depression despite similar baseline symptom severity.Limitation This study was observational, and the treatment modality was naturalistic.Conclusions Anxious depression did not predict worse outcome to antidepressants treatment. This finding might result from exclusion of comorbid anxiety disorder from anxious depression population and allowance of broad treatment modality.

Integrity signals

Registry

Crossref · 10.1016/j.jad.2013.09.037

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Anxious depression defined with the anxious distress specifier was associated with greater depression severity, higher suicidal ideation, decreased quality of life, greater self-reported impairment, severe insomnia, and increased incidence of cardiovascular disease.

    “Also anxious depression defined with the anxious distress specifier was associated with greater depression severity, higher suicidal ideation, decreased QOL, greater self-reported impairment, severe insomnia [10,40], and increased incidence of cardiovascular disease [43].”

    From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [43]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Seo, H.-J., Song, H. R., Jeong, S., Kim, J.-B., Lee, M.-S., Kim, J.-M., Yim, H. W., & Jun, T.-Y.
Affiliations
  • The Catholic University of Korea St. Vincent's Hospital (KR)
  • The Catholic University of Korea Seoul St. Mary's Hospital (KR)
  • Keimyung University (KR)
  • Korea University (KR)
  • Chonnam National University (KR)
  • Catholic University of Korea (KR)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2014-01
Volume
152-154
Pages
352-359
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2013.09.037
OpenAlex
W2061064210
Cited by
13
References
47
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3
FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
anxious depression, subthreshold anxiety, comorbid anxiety disorders, depression treatment response, antidepressant treatment, remission, treatment outcome prediction
MeSH terms
Adult, Antidepressive Agents, Anxiety, Depressive Disorder, Female, Humans, Interview, Psychological, Male, Middle Aged, Psychiatric Status Rating Scales, Remission Induction, Time Factors, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review