Major depressive subtypes and treatment response
Abstract
The purpose of this study was to investigate the relationships between depressive subtypes and response to fluoxetine treatment in a large cohort of outpatients. We studied 294 outpatients with major depressive disorder who were then treated with fluoxetine 20 mg/day for 8 weeks. Treatment outcome was evaluated with the Hamilton Depression Rating Scale (HDRS)-17, the Clinical Global Impressions-Severity, and with the HDRS-8; the latter is proposed to be a relatively more specific measure of depression severity than the HDRS-17. We assessed the relationships between degree of treatment response and several depressive subtypes (melancholic, atypical, hostile, and anxious depression, double depression, and depression with comorbid personality disorders), after adjusting for baseline depression severity. We found that nonanxious depressives (patients without any comorbid anxiety disorder) improved slightly but significantly more during treatment than anxious depressives on all outcome measures. Melancholic depression was associated with slightly less improvement on the HDRS-17 only, whereas the other subtypes of depression were not associated with differences in treatment outcome.
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MDD has a 50% comorbidity with anxiety disorders.
“For example MDD has a 50% comorbidity with anxiety disorders (Fava et al., 1997), making it difficult to ascribe telomere effects to single diagnosis.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Fava et al., 1997
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- Authors
- Fava, M., Uebelacker, L. A., Alpert, J. E., Nierenberg, A. A., Pava, J. A., & Rosenbaum, J. F.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 42
- Issue
- 7
- Pages
- 568-576
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1972105422
- Cited by
- 247
- References
- 44
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 11
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01mh048483-01a1)
- National Institute of Mental Health (R01 MH48483-01)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- major depressive disorder, depression subtypes, fluoxetine, treatment response, endogenous depression, atypical depression, anxious depression, double depression, comorbid personality disorders, comorbid anxiety disorders, depression severity, outpatients
- MeSH terms
- Adolescent, Adult, Aged, Anxiety, Depressive Disorder, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Antidepressive Agents, Second-Generation
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