Smoking topography in response to denicotinized and high-yield nicotine cigarettes in adolescent smokers
Open accessAbstract
Purpose The objective of this study was to explore the smoking topography of adolescent smokers. It is well established that the majority of adult nicotine-dependent smokers began smoking as adolescents. Whereas recent advances have been made with respect to identification of factors that predispose to nicotine dependence, very little is known about the actual smoking behavior (e.g., topography) of adolescent smokers, or its relationship to nicotine dependence. Correspondingly, the extent to which adolescent smokers smoke to obtain nicotine is also unknown.Methods In the present study, we assessed several topographical indices of smoking (e.g., puff volume, puff number) in a sample of 35 light, adolescent smokers. Moreover, we examined whether smoking behavior is different in response to smoking a denicotinized relative to a high-yield, nicotine cigarette.Results All participants evidenced a significant increase in expired air carbon monoxide after the smoking of a cigarette. Results of independent-sample t-tests revealed that adolescents who smoked a low-yield nicotine cigarette took significantly more puffs per cigarette than did those who smoked a high-yield cigarette.Conclusions These findings suggest that adolescent smokers do titrate their nicotine intake in response to smoking denicotinized cigarettes, but do so not by taking larger puffs or smoking more quickly, but by simply taking more puffs per cigarette. Implications of the findings and future directions for this type of research with adolescents are discussed.
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Nicotine follows an inverted U-shaped dose-response curve, and smokers titrate intake to get rewarding effects while avoiding aversive effects of high doses.
“Nicotine follows an inverted U-shaped dose-response curve [18, 60], and smokers titrate their nicotine intake to experience the rewarding while avoiding the aversive effects produced by high nicotine doses [61–64].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [63]
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- Authors
- Kassel, J. D., Greenstein, J. E., Evatt, D. P., Wardle, M. C., Yates, M. C., Veilleux, J. C., & Eissenberg, T.
- Affiliations
- University of Illinois Chicago (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Kassel, Jon D.
- Venue
- Journal of Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 40
- Issue
- 1
- Pages
- 54-60
- ISSN
- 1054-139X (ISSN-L)
- OpenAlex
- W2019325823
- Cited by
- 41
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Adolescent Health (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (5RO1AA12240-04, R01AA012240, 5R01AA12240-04)
- National Cancer Institute (1P01CA98262, P01CA098262, 1PO1CA98262)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- smoking topography, adolescent smokers, nicotine dependence, puff volume, expired carbon monoxide, smoking behavior
- MeSH terms
- Adolescent, Adolescent Behavior, Analysis of Variance, Carbon Monoxide, Chicago, Female, Humans, Male, Nicotine, Smoking, Tobacco Use Disorder, Behavior, Addictive
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