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Cited by 6Nutritional Studies and DietCancer Risks and FactorsPhytoestrogen effects and research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

The Impact of Macronutrient Intake on Sex Steroids During Onset of Puberty

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Biro, Frank M., Summer, Suzanne S., Huang, Bin, Chen, Chen, Benoit, Janie, Pinney, Susan M.·2022·Journal of Adolescent Health
DOI 10.1016/j.jadohealth.2021.10.011PMC PMC8860866
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Abstract

Introduction Increased fiber intake has been associated with decreased breast cancer risk, while increased animal protein intake with increased risk. The objective of this study is to examine the relationship of dietary fiber and protein intake to estrogen and sex hormone-binding globulin (SHBG) concentrations at puberty onset. Methods These analyses were conducted using the Cincinnati puberty cohort of the Breast Cancer and the Environment Research Program, with girls followed every 6 months from ages 6 and 7. The analyses included serum measurements at 6-month intervals for estrogen and SHBG concentrations, from 18 months prior to breast stage 2 (onset of puberty). Dietary intake was documented via 24-hour dietary recalls every 3 months. Dietary factors of interest included total energy intake; total and animal protein; total, soluble, and insoluble fiber; and lignan and flavanol intake. Results This study included 260 participants who generated 871 serum specimens and 3,000 days of diet intake. In longitudinal models, estradiol was associated inversely with insoluble fiber intake; estrone positively with animal protein intake; SHBG with greater insoluble fiber and lower total protein intake; and ratio of estrone to SHBG, a measure of bioavailable estrogen, positively with animal protein. Conclusions Greater protein intake, especially animal protein, led to greater estrogen concentrations and lower SHBG; greater animal protein and greater caloric intake led to increased bioavailable estrogen. This relationship may have served an evolutionary advantage in the past for greater fertility with adequate high-quality protein; in contemporary women, a modest decrease in animal protein may be beneficial in reducing breast cancer risk.

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Metadata

Authors
Biro, F. M., Summer, S. S., Huang, B., Chen, C., Benoit, J., & Pinney, S. M.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • University of Cincinnati (US)
Corresponding author
Biro, Frank M.
ORCID
Venue
Journal of Adolescent Health
Publisher
Elsevier BV
Published
2022-03
Volume
70
Issue
3
Pages
483-487
ISSN
1054-139X (ISSN-L)
DOI
10.1016/j.jadohealth.2021.10.011
PMC
PMC8860866
OpenAlex
W3216064545
Cited by
6
References
35
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2022: 1
FWCI
0.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Adolescent Health (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH
  • National Cancer Institute
  • National Institute of Environmental Health Sciences (R01 ES029133, UL1 RR026314)
  • U.S. Public Health Service (8 UL1 TR000077–05, P30 ES006096)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Keywords
dietary fiber, animal protein intake, macronutrients, puberty onset, sex hormones, estradiol, estrone, sex hormone-binding globulin, lignans, flavonoids, breast cancer risk, adolescent girls
MeSH terms
Child, Eating, Estradiol, Estrogens, Female, Humans, Puberty, Gonadal Steroid Hormones

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