CoChat
Sign Up
Cited by 474Phytoestrogen effects and researchEstrogen and related hormone effectsMenopause: Health Impacts and Treatments

Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women

Goldin, Barry R., Adlercreutz, Herman, Gorbach, Sherwood L., Warram, James H., Dwyer, Johanna T., Swenson, Linda, Woods, Margo N.·1982·New England Journal of Medicine
DOI 10.1056/nejm198212163072502
Open this paper in CoChat — free account

Abstract

We studied 10 vegetarian and 10 nonvegetarian premenopausal women on four occasions approximately four months apart. During each study period, the participants kept three-day dietary records, and estrogens were measured in plasma, urinary, and fecal samples. Vegetarians consumed less total fat than omnivores did (30 per cent of total calories, as compared with 40 per cent) and more dietary fiber (28 g per day, as compared with 12 g). There was a positive correlation between fecal weight and fecal excretion of estrogens in both groups (P less than 0.001), with vegetarians having higher fecal weight and increased fecal excretion of estrogens. Urinary excretion of estriol was lower in vegetarians (P less than 0.05), and their plasma levels of estrone and estradiol were negatively correlated with fecal excretion of estrogen (P = 0.005). Among the vegetarians the beta-glucuronidase activity of fecal bacteria was significantly reduced (P = 0.05). We conclude that vegetarian women have an increased fecal output, which leads to increased fecal excretion of estrogen and a decreased plasma concentration of estrogen.

Integrity signals

Registry

Crossref · 10.1056/nejm198212163072502

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The high-fiber content of the traditional Mediterranean diet can enhance fecal mass and the excretion of estrogens, resulting in reduced plasma concentrations of estrone and estradiol.

    “Moreover, it has been shown that the high-fiber content of the traditional Mediterranean diet can enhance fecal mass and the excretion of estrogens, resulting in reduced plasma concentrations of estrone and estradiol (71).”

    From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [71]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Goldin, B. R., Adlercreutz, H., Gorbach, S. L., Warram, J. H., Dwyer, J. T., Swenson, L., & Woods, M. N.
ORCID
Dwyer, Johanna T.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1982-12-16
Volume
307
Issue
25
Pages
1542-1547
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198212163072502
OpenAlex
W2020203135
Cited by
474
References
37
Citations by year
2026: 1 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 13 · 2014: 2 · 2013: 6 · 2012: 5
FWCI
8.30
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
vegetarian diet, estrogen excretion, fecal estrogen, urinary estriol, plasma estradiol, fecal weight, dietary fiber, dietary fat, beta-glucuronidase, fecal bacteria, premenopausal women, estrogen metabolism
MeSH terms
Adult, Energy Intake, Diet, Dietary Fats, Estradiol, Estrogens, Estrone, Feces, Female, Glucuronidase, Humans, Diet, Vegetarian

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review