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Cited by 38Pharmaceutical Practices and Patient OutcomesDementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive Disorders

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Anticholinergic Medication Use and Risk of Dementia Among Elderly Nursing Home Residents with Depression

Chatterjee, Satabdi, Bali, Vishal, Carnahan, Ryan M., Johnson, Michael L., Chen, Hua, Aparasu, Rajender R.·2016·The American Journal of Geriatric Psychiatry
DOI 10.1016/j.jagp.2015.12.011
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Abstract

Objective To examine the risk of dementia with anticholinergic use among elderly nursing home residents with depression. Design Population-based nested case-control study. Setting Population-based study involving 2007-2010 Minimum Data Set-linked Medicare data from all 50 states. Participants Medicare beneficiaries aged 65 years and older, diagnosed with depression, and no history of dementia as of 2007 (baseline period). Cases were identified as patients with incident dementia following the baseline period. For each case, four age- and sex-matched control subjects were selected using incidence density sampling. Measurements Anticholinergic exposure was defined using Anticholinergic Drug Scale. Prescription of clinically significant anticholinergic medications (levels 2 and 3) 30 days preceding the event date formed the primary exposure. The primary outcome was dementia diagnosis, between January 1, 2008, and December 31, 2010. A conditional logistic regression model stratified on matched case-control sets was performed to assess dementia risk, after controlling for other risk factors. Results The study sample included 28,388 cases diagnosed with dementia and 113,352 matched control subjects. After adjusting for other risk factors, clinically significant anticholinergic use was associated with significant risk of dementia (OR: 1.26; 95% CI: 1.22-1.29) compared with non-use. The findings remained consistent across levels of anticholinergic potency (level 2, OR: 1.37, 95% CI: 1…

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Metadata

Authors
Chatterjee, S., Bali, V., Carnahan, R. M., Johnson, M. L., Chen, H., & Aparasu, R. R.
Affiliations
  • University of Houston (US)
  • University of Iowa (US)
Corresponding author
Aparasu, Rajender R.
ORCID
Venue
The American Journal of Geriatric Psychiatry
Publisher
Elsevier BV
Published
2016-06
Volume
24
Issue
6
Pages
485-495
ISSN
1064-7481 (ISSN-L)
DOI
10.1016/j.jagp.2015.12.011
OpenAlex
W2286484609
Cited by
38
References
2
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 1
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Agency for Healthcare Research and Quality (R01HS021264)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
anticholinergic agents, dementia risk, depression, nursing home residents, older adults, polypharmacy, Anticholinergic Drug Scale, drug safety, incident dementia
MeSH terms
Aged, Aged, 80 and over, Dementia, Depression, Female, Medicare, Homes for the Aged, Humans, Male, Nursing Homes, Risk Factors, United States, Incidence, Logistic Models, Case-Control Studies, Cholinergic Antagonists

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