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Diagnosis and Management of Pollen Food Allergy Syndrome to Nuts

Giovannini, Mattia, Skypala, Isabel J., Caubet, Jean Christoph, Du Toit, George, Nowak-Wegrzyn, Anna·2024·The Journal of Allergy and Clinical Immunology: In Practice
DOI 10.1016/j.jaip.2024.01.025
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Abstract

Oral allergy syndrome or pollen food allergy syndrome (PFAS) represents a common clinical conundrum when the reported trigger food is a tree nut (usually almond or hazelnut) or peanut. The PFAS may give rise to uncertainty about the potential severity of the future reactions, indications for prescribing epinephrine, and the extent of the necessary dietary avoidance. As a food allergy, secondary to cross-reactivity with airborne pollen, PFAS usually manifests toward the end of the first decade of life as contact urticaria of the oropharyngeal mucous membranes. Molecular allergology facilitates diagnosis and risk stratification by establishing the profile of sensitization. Exclusive sensitization to pathogenesis-related proteins family 10 (PR10) and profilins indicates that signs and symptoms are due to PFAS, whereas sensitization to seed storage proteins with or without sensitization to PR10 and profilins may indicate a more severe primary nut allergy phenotype. Management relies on avoidance of the specific nut trigger, advice on the likelihood of more severe local or systemic symptoms, and treatment of reactions according to the severity. Future studies are needed to better delineate the risk of systemic reactions in individuals with nut PFAS and to establish the role of food or pollen allergen immunotherapy for the prevention or moderation of this condition.

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Metadata

Authors
Giovannini, M., Skypala, I. J., Caubet, J. C., Du Toit, G., & Nowak-Wegrzyn, A.
ORCID
Skypala, Isabel J.
Venue
The Journal of Allergy and Clinical Immunology: In Practice
Publisher
Elsevier BV
Published
2024-03
Volume
12
Issue
3
Pages
599-604
ISSN
2213-2198
DOI
10.1016/j.jaip.2024.01.025
Cited by
15
References
0
Language
en
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