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Can patients with oral allergy syndrome be at risk of anaphylaxis?

Skypala, Isabel J.·2020·Current Opinion in Allergy & Clinical Immunology

Abstract

Purpose of review: Oral allergy syndrome, also known as pollen-food syndrome (PFS), is a condition usually associated with adults and characterized by mild transient oropharyngeal symptoms. The purpose of this review is to determine whether systemic or anaphylactic reactions do occur and if so, who is affected and what are the triggers. Recent findings: An increasing number of studies demonstrate that PFS occurs all age groups, and a significant number of affected adults do experience systemic and anaphylactic reactions. The upsurge in the adoption of vegan lifestyles, increase in consumption of fruits and vegetables including smoothies and juices, and use of plant foods in nutritional or body-building supplements, could exacerbate this. Changes in pollen and pollution levels, cofactors and sensitization to other plant food allergens may also be involved. Summary: While the majority of those with PFS will continue to experience mild symptoms, all individuals should be properly advised regarding the dangers of concentrated or unusual forms of plant food allergens such as smoothies, juices, soy/nut milks and nutritional supplements. Further well characterized studies are needed to determine risk factors for severe reactions, and sensitization patterns to pollens and plant food allergens.

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Research works printed but not linked: 65

  1. Mari, 2005, The oral allergy syndrome: improved diagnostic and treatment methods, Curr Opin Allergy Clin Immunol, 5, 267, 10.1097/01.all.0000168793.27948.b0 · DOI
  2. Mastrorilli, 2019, Pollen-food allergy syndrome: a not so rare disease in childhood, Medicina (Kaunas), 55, 641, 10.3390/medicina55100641 · DOI · Paper page
  3. Ortolani, 1988, The oral allergy syndrome, Ann Allergy, 61, 47
  4. Vieths, 1994, Characterization of the 18-kDa apple allergen by two-dimensional immunoblotting and microsequencing, Int Arch Allergy Immunol, 104, 399, 10.1159/000236698 · DOI
  5. Fahlbusch, 1995, Purification and characterization of the major allergen from apple and its allergenic cross-reactivity with Bet v 1, Int Arch Allergy Immunol, 108, 119, 10.1159/000237128 · DOI
  6. Breiteneder, 2000, Molecular and biochemical classification of plant-derived food allergens, J Allergy Clin Immunol, 106, 27, 10.1067/mai.2000.106929 · DOI
  7. van Ree, 1992, Profilin is a cross-reactive allergen in pollen and vegetable foods, Int Arch Allergy Immunol, 98, 97, 10.1159/000236171 · DOI
  8. Scheurer, 2001, Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2, J Chromatogr B Biomed Sci Appl, 756, 315, 10.1016/S0378-4347(01)00090-1 · DOI
  9. Wopfner, 2005, The spectrum of allergens in ragweed and mugwort pollen, Int Arch Allergy Immunol, 138, 337, 10.1159/000089188 · DOI
  10. Cipriani, 2018, Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules, Allergy, 73, 673, 10.1111/all.13338 · DOI
  11. Cipriani, 2019, Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: a longitudinal multicenter study of a patient cohort, Pediatr Allergy Immunol, 30, 325, 10.1111/pai.13036 · DOI
  12. Bohle, 2006, Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo, J Allergy Clin Immunol, 118, 242, 10.1016/j.jaci.2006.03.011 · DOI · Paper page
  13. Wassmann-Otto, 2018, Birch pollen-related foods can cause late eczematous reactions in patients with atopic dermatitis, Allergy, 73, 2046, 10.1111/all.13454 · DOI
  14. Kim, 2019, Clinical characteristics of oral allergy syndrome in children with atopic dermatitis and birch sensitization: a single center study, J Korean Med Sci, 34, e11, 10.3346/jkms.2019.34.e11 · DOI
  15. Asero, 2000, Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion, Int Arch Allergy Immunol, 122, 20, 10.1159/000024355 · DOI
  16. Garcia-Selles, 2002, Patterns of reactivity to lipid transfer proteins of plant foods and Artemisia pollen: an in vivo study, Int Arch Allergy Immunol, 128, 115, 10.1159/000059401 · DOI
  17. Lombardero, 2004, Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens, Clin Exp Allergy, 34, 1415, 10.1111/j.1365-2222.2004.02053.x · DOI
  18. Deng, 2019, Mugwort pollen-related food allergy: lipid transfer protein sensitization and correlation with the severity of allergic reactions in a Chinese population, Allergy Asthma Immunol Res, 11, 116, 10.4168/aair.2019.11.1.116 · DOI · Paper page
  19. An, 2019, Molecular characterization of the thaumatin-like protein PR-NP24 in tomato fruits, J Agric Food Chem, 67, 13001, 10.1021/acs.jafc.9b05256 · DOI
  20. Di Gaspero, 2020, The secondary structure of a major wine protein is modified upon interaction with polyphenols, Molecules, 25, 1646, 10.3390/molecules25071646 · DOI
  21. Inomata, 2017, High prevalence of sensitization to gibberellin-regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: clinical pattern, causative fruits and cofactor effect of gibberellin-regulated protein allergy, J Dermatol, 44, 735, 10.1111/1346-8138.13795 · DOI
  22. Eriksson, 1982, Food hypersensitivity in patients with pollen allergy, Allergy, 37, 437, 10.1111/j.1398-9995.1982.tb02323.x · DOI
  23. Carlson, 2019, Pollen food allergy syndrome (PFAS): a review of current available literature, Ann Allergy Asthma Immunol, 123, 359, 10.1016/j.anai.2019.07.022 · DOI · Paper page
  24. Ma, 2003, A survey on the management of pollen-food allergy syndrome in allergy practices, J Allergy Clin Immunol, 112, 784, 10.1016/S0091-6749(03)02008-6 · DOI
  25. Cho, 2019, Common causes of emergency department visits for anaphylaxis in Korean community hospitals: a cross-sectional study, Medicine (Baltimore), 98, e14114, 10.1097/MD.0000000000014114 · DOI
  26. Kim, 2018, Pollen-food allergy syndrome in Korean pollinosis patients: a nationwide survey, Allergy Asthma Immunol Res, 10, 648, 10.4168/aair.2018.10.6.648 · DOI
  27. Kim, 2019, Clinical manifestations and risk factors of anaphylaxis in pollen-food allergy syndrome, Yonsei Med J, 60, 960, 10.3349/ymj.2019.60.10.960 · DOI · Paper page
  28. Ozdemir, 2018, Pollen food allergy syndrome in Turkey: clinical characteristics and evaluation of its association with skin test reactivity to pollens, Asian Pac J Allergy Immunol, 36, 77
  29. Guvenir, 2020, Frequency and clinical features of pollen-food syndrome in children, Allergol Immunopathol (Madr), 48, 78, 10.1016/j.aller.2019.07.010 · DOI
  30. Alvarado, 2014, Profilin as a severe food allergen in allergic patients overexposed to grass pollen, Allergy, 69, 1610, 10.1111/all.12509 · DOI · Paper page
  31. Skypala, 2011, Development and validation of a structured questionnaire for the diagnosis of oral allergy syndrome in subjects with seasonal allergic rhinitis during the UK birch pollen season, Clin Exp Allergy, 41, 1001, 10.1111/j.1365-2222.2011.03759.x · DOI
  32. Scala, 2015, Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort, Allergy, 70, 933, 10.1111/all.12635 · DOI
  33. Pascal, 2012, Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens, Clin Exp Allergy, 42, 1529, 10.1111/j.1365-2222.2012.04071.x · DOI
  34. Skypala, 2019, Lipid transfer protein allergy in the United Kingdom: characterization and comparison with a matched Italian cohort, Allergy, 74, 1340, 10.1111/all.13747 · DOI
  35. Ahmed, 2020, Consumption of fruit and vegetables and the risk of type 2 diabetes: a 4-year longitudinal study among Swedish adults, J Nutr Sci, 9, e14, 10.1017/jns.2020.7 · DOI
  36. Elsahoryi, 2020, Association between overall fruit and vegetable intake, and fruit and vegetable sub-types and blood pressure: the PRIME study (Prospective Epidemiological Study of Myocardial Infarction), Br J Nutr, 1
  37. Tian, 2018, Fruit and vegetable consumption and risk of the metabolic syndrome: a meta-analysis, Public Health Nutr, 21, 756, 10.1017/S136898001700310X · DOI
  38. Vereecken, 2015, Fruit and vegetable consumption trends among adolescents from 2002 to 2010 in 33 countries, Eur J Public Health, 25, 16, 10.1093/eurpub/ckv012 · DOI
  39. Makkapati, 2018, Green smoothie cleanse’ causing acute oxalate nephropathy, Am J Kidney Dis, 71, 281, 10.1053/j.ajkd.2017.08.002 · DOI
  40. Blacker, 2013, An in vitro investigation of the erosive potential of smoothies, Br Dent J, 214, E9, 10.1038/sj.bdj.2013.164 · DOI
  41. Masthoff, 2013, A systematic review of the effect of thermal processing on the allergenicity of tree nuts, Allergy, 68, 983, 10.1111/all.12185 · DOI
  42. Martini, 2019, Anaphylaxis to baobab fruit: the paradox of ‘natural healthy food’, Eur Ann Allergy Clin Immunol, 51, 282, 10.23822/EurAnnACI.1764-1489.91 · DOI
  43. Papia, 2020, Allergic reactions to genus Morus plants: a review, Clin Mol Allergy, 18, 1, 10.1186/s12948-020-00116-7 · DOI
  44. Takaoka, 2019, Allergy and anaphylactic reaction to loquat (Eriobotrya japonica) are induced by a Bet v 1 homolog, J Investig Allergol Clin Immunol, 29, 382, 10.18176/jiaci.0406 · DOI
  45. Costa, 2019, ‘More than a diet’: a qualitative investigation of young vegan Women's relationship to food, Appetite, 143, 104418, 10.1016/j.appet.2019.104418 · DOI
  46. Bolhaar, 2004, Allergy to jackfruit: a novel example of Bet v 1-related food allergy, Allergy, 59, 1187, 10.1111/j.1398-9995.2004.00544.x · DOI
  47. Wongrakpanich, 2015, Jackfruit anaphylaxis in a latex allergic patient, Asian Pac J Allergy Immunol, 33, 65
  48. Mittag, 2004, Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens, J Allergy Clin Immunol, 113, 148, 10.1016/j.jaci.2003.09.030 · DOI
  49. Yamamoto, 2015, Oral allergy syndrome following soy milk ingestion in patients with birch pollen allergy, Nihon Jibiinkoka Gakkai Kaiho, 118, 1124, 10.3950/jibiinkoka.118.1124 · DOI
  50. Ballmer-Weber, 2002, Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy, Allergy, 57, 228, 10.1034/j.1398-9995.2002.1o3319.x · DOI
  51. Sancho, 2011, Responsiveness of the major birch allergen Bet v 1 scaffold to the gastric environment: impact on structure and allergenic activity, Mol Nutr Food Res, 55, 1690, 10.1002/mnfr.201100025 · DOI
  52. Rib-Schmidt, 2018, pH and heat resistance of the major celery allergen Api g 1, Mol Nutr Food Res, 62, 1700886, 10.1002/mnfr.201700886 · DOI
  53. Lyons, 2018, Dietary interventions in pollen-related food allergy, Nutrients, 10, 1520, 10.3390/nu10101520 · DOI
  54. Hanafusa, 2018, Worm wounding increases levels of pollen-related food allergens in soybean (Glycine max), Biosci Biotechnol Biochem, 82, 1207, 10.1080/09168451.2018.1456319 · DOI
  55. Wang, 2019, Effect of preharvest and postharvest conditions on the fruit allergenicity: a review, Crit Rev Food Sci Nutr, 59, 1027, 10.1080/10408398.2017.1389691 · DOI
  56. Christensen, 2019, Wheat-dependent cofactor-augmented anaphylaxis: a prospective study of exercise, aspirin, and alcohol efficacy as cofactors, J Allergy Clin Immunol Pract, 7, 114, 10.1016/j.jaip.2018.06.018 · DOI
  57. Romano, 2012, Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxis, Clin Exp Allergy, 42, 1643, 10.1111/cea.12011 · DOI
  58. Senders, 2018, Food-dependent exercise-induced anaphylaxis due to almond in a PR-10-sensitized patient, J Allergy Clin Immunol Pract, 6, 683, 10.1016/j.jaip.2017.12.018 · DOI
  59. Biedermann, 2019, Birch pollen allergy in Europe, Allergy, 74, 1237, 10.1111/all.13758 · DOI · Paper page
  60. Gross, 2019, The impact of weather and climate on pollen concentrations in Denver, Colorado, 2010–2018, Ann Allergy Asthma Immunol, 123, 494, 10.1016/j.anai.2019.08.002 · DOI
  61. Berger, 2020, Impact of air pollution on symptom severity during the birch, grass and ragweed pollen period in Vienna, Austria: importance of O3 in 2010–2018, Environ Pollut, 263, 114526, 10.1016/j.envpol.2020.114526 · DOI
  62. Kosma, 2011, Severe reactions after the intake of soy drink in birch pollen-allergic children sensitized to Gly m 4, Acta Paediatr, 100, 305, 10.1111/j.1651-2227.2010.02049.x · DOI
  63. Asero, 2020, Labile plant food allergens: really so harmless? Case series and literature review, Allergy, 75, 1517, 10.1111/all.14184 · DOI
  64. Blockhuys, 2017, Bariatric surgery: a novel risk factor for food allergy?, Int Arch Allergy Immunol, 172, 64, 10.1159/000455123 · DOI
  65. Untersmayr, 2005, Antiulcer drugs promote IgE formation toward dietary antigens in adult patients, FASEB J, 19, 656, 10.1096/fj.04-3170fje · DOI

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Metadata

Authors
Skypala, I. J.
Affiliations
Royal Brompton & Harefield NHS Foundation Trust
Venue
Current Opinion in Allergy & Clinical Immunology
Published
2020-07-28
Volume
20
Issue
5
Pages
459-464
ISSN
  • 1528-4050
  • 1473-6322
Cited by
30
References
1
Language
en

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Skypala, I. J. (2020). Can patients with oral allergy syndrome be at risk of anaphylaxis? Current Opinion in Allergy & Clinical Immunology. https://doi.org/10.1097/aci.0000000000000679