CoChat
Sign Up
Cited by 568Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAging and Gerontology Research

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Outcome over seven years of healthy adults with and without subjective cognitive impairment

Open access
Reisberg, Barry, Shulman, Melanie B., Torossian, Carol, Leng, Ling, Zhu, Wei·2010·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2009.10.002PMC PMC3873197
Open this paper in CoChat — free account

Abstract

Background: Subjective cognitive impairment (SCI) in older persons without manifest symptomatology is a common condition with a largely unclear prognosis. We hypothesized that (1) examining outcome for a sufficient period by using conversion to mild cognitive impairment (MCI) or dementia would clarify SCI prognosis, and (2) with the aforementioned procedures, the prognosis of SCI subjects would differ significantly from that of demographically matched healthy subjects, free of SCI, termed no cognitive impairment (NCI) subjects. Methods: A consecutive series of healthy subjects, aged ≥40 years, presenting with NCI or SCI to a brain aging and dementia research center during a 14‐year interval, were studied and followed up during an 18‐year observation window. The study population (60 NCI, 200 SCI, 60% female) had a mean age of 67.2 ± 9.1 years, was well‐educated (mean, 15.5 ± 2.7 years), and cognitively normal (Mini‐Mental State Examination, 29.1 ± 1.2). Results: A total of 213 subjects (81.9% of the study population) were followed up. Follow‐up occurred during a mean period of 6.8 ± 3.4 years, and subjects had a mean of 2.9 ± 1.6 follow‐up visits. Seven NCI (14.9%) and 90 SCI (54.2%) subjects declined (P < .0001). Of NCI decliners, five declined to MCI and two to probable Alzheimer's disease. Of SCI decliners, 71 declined to MCI and 19 to dementia diagnoses. Controlling for baseline demographic variables and follow‐up time, Weibull proportional hazards model revealed increased decline in SCI subjects (hazard ratio, 4.5; 95% confidence interval, 1.9–10.3), whereas the accelerated failure time model analysis with an underlying Weibull survival function showed that SCI subjects declined more rapidly, at 60% of the rate of NCI subjects (95% confidence interval, 0.45–0.80). Furthermore, mean time to decline was 3.5 years longer for NCI than for SCI subjects (P = .0003). Conclusions: These results indicate that SCI in subjects with normal cognition is a harbinger of further decline in most subjects during a 7‐year mean follow‐up interval. Relevance for community populations should be investigated, and prevention studies in this at‐risk population should be explored.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jalz.2009.10.002

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 55 references

Research works printed but not linked: 2

  1. Reisberg B, 1985, Geriatric psychiatry: ethical and legal issues, 37
  2. Hsieh HK, 1988, Savage test Encyclopedia of statistical sciences. Vol 8, 267

Cited by

Sorted by citations

Items 401–500 of 567

Related

See all

Metadata

Authors
Reisberg, B., Shulman, M. B., Torossian, C., Leng, L., & Zhu, W.
Affiliations
  • New York University (US)
  • Stony Brook University (US)
  • State University of New York (US)
Corresponding author
Reisberg, Barry
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2010-01
Volume
6
Issue
1
Pages
11-24
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2009.10.002
PMC
PMC3873197
OpenAlex
W2107537187
Cited by
568
References
55
Citations by year
2026: 16 · 2025: 23 · 2024: 32 · 2023: 29 · 2022: 36 · 2021: 52 · 2020: 58 · 2019: 53 · 2018: 49 · 2017: 36 · 2016: 42 · 2015: 50 · 2014: 35 · 2013: 23 · 2012: 15
FWCI
12.46
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P30 AG08051, AG03051, AG09127, AG11505)
  • National Institutes of Health (MH43486)
  • Forest Laboratories
  • National Center for Research Resources (M01 RR00096)
  • Fisher Center for Alzheimer's Research Foundation
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords
subjective cognitive impairment, mild cognitive impairment
MeSH terms
Age Factors, Aged, Cognition Disorders, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Retrospective Studies, Geriatric Assessment, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review