Cited by 112Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

The effect of TOMM40 poly‐T length on gray matter volume and cognition in middle‐aged persons with APOEɛ 3/ɛ 3 genotype

Open access

Johnson, Sterling C., La Rue, Asenath, Hermann, Bruce P., Xu, Guofan, Koscik, Rebecca L., Jonaitis, Erin M., Bendlin, Barbara B., Hogan, Kirk J., Roses, Allen D., Saunders, Ann M., Lutz, Michael W., Asthana, Sanjay, Green, Robert C., Sager, Mark A.·2011·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2010.11.012PMC PMC3143375

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Apolipoprotein E (APOE) genotypes are associated with variable risk of developing late-onset Alzheimer's disease (LOAD), with APOE epsilon 4 (APOE ε4) having higher risk. A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset. In this study, we tested the hypothesis that brain and cognitive changes suggestive of presymptomatic LOAD may be associated with this TOMM40 polymorphism. METHODS: Among healthy APOE ε3 homozygous adults (N = 117; mean age, 55 years), we compared those who were homozygous for VL/VL (n = 35) TOMM40 poly-T lengths (who were presumably at higher risk) with those homozygous for short (S/S; n = 38) poly-T lengths, as well as those with heterozygous (S/VL; n = 44) poly-T length polymorphisms, on measures of learning and memory and on structural brain imaging. RESULTS: The VL/VL group showed lower performance than the S/S TOMM40 group on primacy retrieval from a verbal list learning task, a finding which is also seen in early Alzheimer's disease. A dose-dependent increase in the VL TOMM40 polymorphism (from no VL alleles, to S/VL heterozygous, to VL/VL homozygous) was associated with decreasing gray matter volume in the ventral posterior cingulate and medial ventral precuneus, a region of the brain affected early in LOAD. CONCLUSIONS: These findings among APOE ε3/ε3 late middle-aged adults suggest that a subgroup with VL TOMM40 poly-T lengths may be experiencing incipient LOAD-related cognitive and brain changes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jalz.2010.11.012

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Self-citation
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Self-citation
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
Imaging β-amyloid burden in aging and dementia
Rowe, C. C., Ng, S., Ackermann, U., Gong, S. J., Pike, K., Savage, G., Cowie, T. F., Dickinson, K. L., Maruff, P., Darby, D., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000261919.22630.ea · Cited by 1,104
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
Jack, C. R., Petersen, R. C., Xu, Y., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., & Kokmen, E. (2000) · Neurology · doi:10.1212/wnl.55.4.484 · Cited by 937
Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis
Bäckman, L., Jones, S., Berger, A.-K., Laukka, E. J., & Small, B. J. (2005) · Neuropsychology · doi:10.1037/0894-4105.19.4.520 · Cited by 735

Show all 41 references

Sorted by citations

Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137
Self-citation
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
Vogt, N. M., Romano, K. A., Darst, B. F., Engelman, C. D., Johnson, S. C., Carlsson, C. M., Asthana, S., Blennow, K., Zetterberg, H., Bendlin, B. B., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0451-2 · Cited by 471
Self-citation
Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease
Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C., La Rue, A., Hermann, B. P., Koscik, R. L., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0613 · Cited by 418
Self-citation
Insulin resistance predicts brain amyloid deposition in late middle‐aged adults
Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J. M., Statz, E. H., Hermann, B. P., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.03.011 · Cited by 267
Self-citation
Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update
Cenini, G., & Voos, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00902 · Cited by 257
Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle–Aged Adults
Willette, A. A., Xu, G., Johnson, S. C., Birdsill, A. C., Jonaitis, E. M., Sager, M. A., Hermann, B. P., Rue, A. L., Asthana, S., & Bendlin, B. B. (2012) · Diabetes Care · doi:10.2337/dc12-0922 · Cited by 233
Self-citation
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing
Davies, G., Harris, S. E., Reynolds, C. A., Payton, A., Knight, H. M., Liewald, D. C. M., Lopez, L. M., Luciano, M., Gow, A. J., Corley, J., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.159 · Cited by 179
Self-citation
APOE alleles and diet in brain aging and Alzheimer's disease
Yassine, H. N., & Finch, C. E. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00150 · Cited by 145
Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography
Coughlan, G., Betthauser, T. J., Boyle, R. T., Koscik, R. L., Klinger, H. M., Chibnik, L. B., Jonaitis, E. M., Yau, W. W., Wenzel, A., Christian, B. T., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.0455 · Cited by 136
Self-citation
Healthy Aging and Dementia: Two Roads Diverging in Midlife?
Irwin, K. E., Sexton, C. E., Daniel, T., LAWLOR, B. A., & Naçi, L. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00275 · Cited by 132
Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer
Palmer, C. S., Anderson, A. J., & Stojanovski, D. (2020) · FEBS Letters · doi:10.1002/1873-3468.14022 · Cited by 126
Verbal Fluency and Early Memory Decline: Results from the Wisconsin Registry for Alzheimer's Prevention
Mueller, K. D., Koscik, R. L., LaRue, A. A., Clark, L. R., Hermann, B. P., Johnson, S. C., & Sager, M. A. (2015) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acv030 · Cited by 107
Self-citation
Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region
Jun, G., Vardarajan, B. N., Buros, J. L., Yu, C., Hawk, M., Dombroski, B. A., Crane, P. K., Larson, E. B., Mayeux, R. P., Haines, J. L., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.2052 · Cited by 103
Connected Language in Late Middle-Aged Adults at Risk for Alzheimer’s Disease
Mueller, K. D., Koscik, R. L., Turkstra, L. S., Riedeman, S. K., LaRue, A. A., Clark, L. R., Hermann, B. P., Sager, M. A., & Johnson, S. C. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160252 · Cited by 109
Self-citation
Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106
The cis ‐regulatory effect of an Alzheimer's disease‐associated poly‐T locus on expression of TOMM40 and apolipoprotein E genes
Linnertz, C. L., Anderson, L., Gottschalk, W. K., Crenshaw, D. G., Lutz, M. W., Allen, J., Saith, S., Mihovilovic, M., Burke, J. R., Welsh-Bohmer, K. A., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.08.280 · Cited by 90
Self-citation
The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer’s Disease
Chhimpa, N., Singh, N., Puri, N., & Kayath, H. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220514 · Cited by 89
Sirtuins in Alzheimer’s Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics
Cacabelos, R., Carril, J. C., Cacabelos, N., Kazantsev, A. G., Vostrov, A. A., Corzo, L., Cacabelos, P., & Goldgaber, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051249 · Cited by 87
White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease
Adluru, N., Destiche, D. J., Lu, S. Y.-F., Doran, S. T., Birdsill, A. C., Melah, K. E., Okonkwo, O. C., Alexander, A. L., Dowling, N. M., Johnson, S. C., et al. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.04.008 · Cited by 85
Self-citation
Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention
Бачурин, С. О., Si, G., Samsonova, A. N., Barreto, G. E., & Aliev, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.021 · Cited by 84
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview
Swerdlow, R. H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221286 · Cited by 88
The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk
Fan, J., Tao, W., Li, X., Li, H., Zhang, J., Wei, D., Chen, Y., & Zhang, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051177 · Cited by 87
APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
Wolf, A. B., Caselli, R. J., Reiman, E. M., & Valla, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.011 · Cited by 84
Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE ɛ4 Carriers
Starks, E. J., O’Grady, J. P., Hoscheidt, S. M., Racine, A. M., Carlsson, C. M., Zetterberg, H., Blennow, K., Okonkwo, O. C., Puglielli, L., Asthana, S., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150072 · Cited by 82
Self-citation
TOMM40 ′523 variant and cognitive decline in older persons with APOE ε3/3 genotype
Yu, L., Lutz, M. W., Wilson, R. S., Burns, D. K., Roses, A. D., Saunders, A. M., Gaiteri, C., Jager, P. L. D., Barnes, L. L., & Bennett, D. A. (2017) · Neurology · doi:10.1212/wnl.0000000000003614 · Cited by 79
Self-citation
Journal of Parkinson’s disease & Alzheimer’s disease
Gottschalk, W. K., Lutz, M. W., He, Y. T., Saunders, A. M., Burns, D. K., Roses, A. D., & Chiba‐Falek, O. (2014) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000003 · Cited by 80
Self-citation
Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer’s disease
Cody, K. A., Langhough, R. E., Zammit, M. D., Clark, L. R., Chin, N. A., Christian, B. T., Betthauser, T. J., & Johnson, S. C. (2024) · Brain · doi:10.1093/brain/awae116 · Cited by 71
Self-citation
The Alu neurodegeneration hypothesis: A primate‐specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease
Larsen, P. A., Lutz, M. W., Hunnicutt, K. E., Mihovilovic, M., Saunders, A. M., Yoder, A. D., & Roses, A. D. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.017 · Cited by 74
Self-citation
Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
Lyall, D. M., Harris, S. E., Bastin, M. E., Maniega, S. M., Murray, C. L., Lutz, M. W., Saunders, A. M., Roses, A. D., Hernández, M. D. C. V., Royle, N. A., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.006 · Cited by 70
Self-citation
Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes
Mak, E., Gabel, S., Mirette, H., Su, L., Williams, G. B., Waldman, A., Wells, K., Ritchie, K., Ritchie, C., & O’Brien, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.001 · Cited by 71
Using genetics to enable studies on the prevention of Alzheimer's disease
Crenshaw, D. G., Gottschalk, W. K., Lutz, M. W., Grossman, I., Saunders, A. M., Burke, J. R., Welsh-Bohmer, K. A., Brannan, S. K., Burns, D. K., & Roses, A. D. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.222 · Cited by 70
Self-citation
Genome-wide pathway analysis of memory impairment in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks
Initiative, A. D. N., Ramanan, V. K., Kim, S., Nudelman, K. N. H., Shen, L., Nho, K. T., Risacher, S. L., Foroud, T., Mukherjee, S., Crane, P. K., et al. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9196-x · Cited by 66
The effects of the TOMM40 poly‐T alleles on Alzheimer's disease phenotypes
Chiba‐Falek, O., Gottschalk, W. K., & Lutz, M. W. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.01.015 · Cited by 59
Self-citation
Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations
Linnertz, C. L., Saunders, A. M., Lutz, M. W., Crenshaw, D. G., Grossman, I., Burns, D. K., Whitfield, K. E., Hauser, M. A., McCarthy, J. J., Carnes, M. U., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030994 · Cited by 58
Self-citation
The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease
Zeitlow, K., Charlambous, L., Ng, I., Gagrani, S., Mihovilovic, M., Luo, S., Rock, D. L., Saunders, A. M., Roses, A. D., & Gottschalk, W. K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.031 · Cited by 56
Self-citation
A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
Hayden, K. M., McEvoy, J. M., Linnertz, C., Attix, D., Kuchibhatla, M., Saunders, A. M., Lutz, M. W., Welsh‐Bohmer, K. A., Roses, A. D., & Chiba‐Falek, O. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.005 · Cited by 53
Self-citation
TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity
Maruszak, A., Pepłońska, B., Safranow, K., Chodakowska-Żebrowska, M., Barcikowska, M., & Żekanowski, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110743 · Cited by 50
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study
Wang, R., Oh, J. M., Motovylyak, A., Ma, Y., Sager, M. A., Rowley, H. A., Johnson, K. M., Gallagher, C. L., Carlsson, C. M., Bendlin, B. B., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211021313 · Cited by 49
Self-citation
TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer’s Disease
Chen, Y., Chang, S., Lee, Y., Ho, W.-M., Huang, Y.-H., Wu, Y.-Y., Chu, Y.-C., Wu, K.-H., Wei, L.-S., Wang, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044085 · Cited by 48
Stressful Events, Social Support, and Cognitive Function in Middle-Aged Adults With a Family History of Alzheimer’s Disease
Zuelsdorff, M. L., Engelman, C. D., Friedman, E. M., Koscik, R. L., Jonaitis, E. M., Rue, A. L., & Sager, M. A. (2013) · Journal of Aging and Health · doi:10.1177/0898264313498416 · Cited by 46
Self-citation
A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging
Payton, A., Sindrewicz, P., Pessoa, V., Platt, H., Horan, M. A., Ollier, W., Bubb, V. J., Pendleton, N., & Quinn, J. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.017 · Cited by 44
Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease
Initiative, A. D. N., Nho, K. T., Kim, S., Horgusluoglu, E., Risacher, S. L., Shen, L., Kim, D., Lee, S., Foroud, T., Shaw, L. M. J., et al. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0267-0 · Cited by 44
Self-citation
Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults
Vogt, N. M., Hunt, J. F. V., Adluru, N., Ma, Y., Hulle, C. A. V., Dean, D., Kecskemeti, S., Chin, N. A., Carlsson, C. M., Asthana, S., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12364 · Cited by 42
Self-citation
The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment
Laczó, J., Andel, R., Vyhnálek, M., Maťoška, V., Kaplan, V., Nedelská, Z., Lerch, O., Gažová, I., Moffat, S. D., & Hort, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.03.004 · Cited by 41
Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936
Lyall, D. M., Royle, N. A., Harris, S. E., Bastin, M. E., Maniega, S. M., Murray, C. L., Lutz, M. W., Saunders, A. M., Roses, A. D., Hernández, M. C. D. V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080513 · Cited by 37
Self-citation
Biothiols and oxidative stress markers and polymorphisms ofTOMM40andAPOC1genes in Alzheimer’s disease patients
Prendecki, M., Florczak‐Wyspianska, J., Kowalska, M., Ilkowski, J., Grzelak, T., Bialas, K., Wiszniewska, M., Kozubski, W. P., & Dorszewska, J. (2018) · Oncotarget · doi:10.18632/oncotarget.26184 · Cited by 38
Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort
Arpawong, T. E., Pendleton, N., Mekli, K., McArdle, J. J., Gatz, M., Armoskus, C., Knowles, J. A., & Prescott, C. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182448 · Cited by 38
Social support and verbal interaction are differentially associated with cognitive function in midlife and older age
Zuelsdorff, M. L., Koscik, R. L., Okonkwo, O. C., Peppard, P. E., Hermann, B. P., Sager, M. A., Johnson, S. C., & Engelman, C. D. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1414769 · Cited by 44
Self-citation
Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle‐Aged Adults
O’Grady, J. P., Dean, D., Yang, K. L., Canda, C., Hoscheidt, S. M., Starks, E. J., Merluzzi, A. P., Hurley, S. A., Davenport, N. J., Okonkwo, O. C., et al. (2019) · Obesity · doi:10.1002/oby.22558 · Cited by 37
Self-citation
Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population
Ma, X., Yu, J., Wang, W., Wang, H.-F., Liu, Q., Zhang, W., & Tan, L. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8217-7 · Cited by 35
Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease
Heinemeyer, T., Stemmet, M., Bardien, S., & Neethling, A. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4292 · Cited by 35
TOMM40 genetic variants associated with healthy aging and longevity: a systematic review
Chen, S., Sarasua, S. M., Davis, N. J., DeLuca, J. M., Boccuto, L., Thielke, S. M., & Yu, C. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03337-4 · Cited by 33
The Role of Upregulated APOE in Alzheimer's Disease Etiology
Gottschalk, W. K., & Mihovilovic, M. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000209 · Cited by 33
Opportunities in pharmacogenomics for the treatment of Alzheimer’s disease
Cacabelos, R., Torrellas, C., & Carrera, I. (2015) · Future Neurology · doi:10.2217/fnl.15.12 · Cited by 32
Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence ofAPOEandTOMM40on Brain Integrity
Ferencz, B., Karlsson, S., & Kalpouzos, G. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/421452 · Cited by 35
New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics
Lutz, M. W., Crenshaw, D. G., Welsh-Bohmer, K. A., Burns, D. K., & Roses, A. D. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0643-8 · Cited by 33
Self-citation
TOMM40 intron 6 poly‐T length, age at onset, and neuropathology of AD in individuals with APOE ɛ3/ɛ3
Li, G., Bekris, L. M., Leong, L., Steinbart, E. J., Shofer, J. B., Crane, P. K., Larson, E. B., Peskind, E. R., Bird, T. D., & Yu, C. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.06.009 · Cited by 30
A genetics-based biomarker risk algorithm for predicting risk of Alzheimer's disease
Lutz, M. W., Sundseth, S. S., Burns, D. K., Saunders, A. M., Hayden, K. M., Burke, J. R., Welsh‐Bohmer, K. A., Roses, A. D., & Initiative, A. D. N. (2016) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2015.12.002 · Cited by 30
Self-citation
Neuropathologic features of TOMM40 '523 variant on late‐life cognitive decline
Yu, L., Lutz, M. W., Farfel, J. M., Wilson, R. S., Burns, D. K., Saunders, A. M., Jager, P. L. D., Barnes, L. L., Schneider, J. A., & Bennett, D. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.05.002 · Cited by 29
Self-citation
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes
Greenbaum, L., Ravona‐Springer, R., Lutz, M. W., Heymann, A. D., Lubitz, I., Cooper, I., Kravitz, E., Sano, M. C., Roses, A. D., Silverman, J. M., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.06.002 · Cited by 27
Self-citation
Multi-resolutional shape features via non-Euclidean wavelets: Applications to statistical analysis of cortical thickness
Kim, W. H., Singh, V., Chung, M. K., Chris Hinrichs, A., Pachauri, D., Okonkwo, O. C., & Johnson, S. C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.02.028 · Cited by 29
Self-citation
Hippocampal thinning linked to longer TOMM40 poly‐T variant lengths in the absence of the APOE ε4 variant
Burggren, A. C., Mahmood, Z., Harrison, T. M., Siddarth, P., Miller, K. J., Small, G. W., Merrill, D. A., & Bookheimer, S. Y. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.12.009 · Cited by 27
Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity
Bruno, D., Mueller, K. D., Betthauser, T. J., Chin, N. A., Engelman, C. D., Christian, B. T., Koscik, R. L., & Johnson, S. C. (2020) · Journal of Neuropsychology · doi:10.1111/jnp.12235 · Cited by 26
Self-citation
Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?
Lyall, D. M., Harris, S. E., Bastin, M. E., Maniega, S. M., Murray, C. L., Lutz, M. W., Saunders, A. M., Roses, A. D., Hernández, M. D. C. V., Royle, N. A., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.89 · Cited by 26
Self-citation
TOMM40 rs2075650 May Represent a New Candidate Gene for Vulnerability to Major Depressive Disorder
McFarquhar, M., Elliott, R., McKie, S., Thomas, E., Downey, D., Mekli, K., Toth, Z. G., Anderson, I. M., Deakin, J. F. W., & Juhász, G. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.22 · Cited by 27
DNA methylation in genes associated with the evolution of ageing and disease: A critical review
Auley, M. T. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101488 · Cited by 25
Multiple Diffusivities Define White Matter Degeneration in Amnestic Mild Cognitive Impairment and Alzheimer's Disease
Wang, P., Chou, K., Lirng, J.-F., Lin, K.-N., Chen, W., & Lin, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111304 · Cited by 23
Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease
Nicholas, C. R. N., Dowling, N. M., Racine, A. M., Clark, L. R., Berman, S. E., Koscik, R. L., Asthana, S., Hermann, B. P., Sager, M. A., & Johnson, S. C. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000509 · Cited by 22
Self-citation
Neurovascular Invasion and Histological Grade Serve as the Risk Factors of Cervical Lymph Node Metastases in Early Tongue Squamous Cell Carcinoma
Wu, K., Yang, X., Li, L., Ruan, M., Liu, W., Lu, W., Zhang, C., & Li, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9175-5 · Cited by 21
Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE‐ε4/TOMM40 long poly‐T repeat allele variants
Prokopenko, I., Miyakawa, G., Zheng, B., Heikkinen, J., Petrova, D., Udeh‐Momoh, C. T., Claringbould, A., Neumann, J., Haytural, H., Kaakinen, M., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.08.005 · Cited by 22
The TOMM40 ‘523’ polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson’s disease
Bakeberg, M. C., Hoes, M. E., Gorecki, A. M., Theunissen, F., Pfaff, A. L., Kenna, J. E., Plunkett, K., Kõks, S., Akkari, P. A., Mastaglia, F. L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85510-0 · Cited by 20
Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
Cody, K. A., Koscik, R. L., Erickson, C. M., Berman, S. E., Jonaitis, E. M., Williams, V. J., Mueller, K. D., Christian, B. T., Chin, N. A., Clark, L. R., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12351 · Cited by 21
Self-citation
The association between TOMM40 gene polymorphism and spontaneous brain activity in amnestic mild cognitive impairment
Liu, X., Bai, F., Yue, C., Shi, Y., Yu, H., Luo, B., & Zhang, Z. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7368-x · Cited by 20
TOMM40‐APOE haplotypes are associated with cognitive decline in non‐demented Blacks
Deters, K., Mormino, E. C., Yu, L., Lutz, M. W., Bennett, D. A., & Barnes, L. L. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12295 · Cited by 20
Self-citation
Fecal short‐chain fatty acids vary by sex and amyloid status
Kuehn, J. F., Zhang, Q., Heston, M. B., Kang, J. W., Harding, S. J., Davenport‐Sis, N. J., Peter, D. C., Kerby, R. L., Vemuganti, V., Schiffmann, E. C., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70877 · Cited by 19
Self-citation
Biochemical Studies of Poly-T Variants in the Alzheimer's Disease Associated TOMM40 Gene
Hedskog, L., Brohede, J., Wiehager, B., Pinho, C. M., Revathikumar, P., Lilius, L., Glaser, E. G., Graff, C., Karlström, H., & Ankarcrona, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120580 · Cited by 17
Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants
Bruno, D., Nierenberg, J. J., Ritchie, J., Lutz, M. W., & Pomara, N. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.006 · Cited by 17
Self-citation
APOE-TOMM40 in the Pharmacogenomics of Dementia
Cacabelos, R. (2013) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000135 · Cited by 17
Neuroimaging and genetic risk for Alzheimer’s disease and addiction-related degenerative brain disorders
Roussotte, F. F., Daianu, M., Jahanshad, N., Leonardo, C. D., & Thompson, P. M. (2013) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9263-y · Cited by 16
A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases
Soyal, S. M., Kwik, M., Kalev, O., Lenz, S., Zara, G., Strasser, P., Patsch, W., & Weis, S. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1317 · Cited by 16
Alzheimer’s disease cortical morphological phenotypes are associated with TOMM40′523-APOE haplotypes
Honea, R. A., Hunt, S. L., Lepping, R. J., Vidoni, E. D., Morris, J. K., Watts, A. S., Michaelis, E. K., Burns, J. M., & Swerdlow, R. H. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.001 · Cited by 12
An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration
Periasamy, A., Mitchell, N. C., Zaytseva, O., Chahal, A., Zhao, J., Colman, P. M., Quinn, L. M., & Gulbis, J. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-23280-z · Cited by 13
Biomarkers for the early diagnosis of Alzheimer's disease: The challenge of XXI century
Contino, M., Cantore, M., Leopoldo, M., & Colabufo, N. (2013) · Advances in Alzheimer s Disease · doi:10.4236/aad.2013.21003 · Cited by 16
Role of TOMM40 rs10524523 Polymorphism in Onset of Alzheimer's Disease Caused by the PSEN1 M146L Mutation
Bernardi, L., Gallo, M., Anfossi, M., Conidi, M. E., Colao, R., Puccio, G., Curcio, S. A. M., Frangipane, F., Clodomiro, A., Mirabelli, M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130119 · Cited by 13
Towards precision medicine in Alzheimer’s disease: deciphering genetic data to establish informative biomarkers
Chiba‐Falek, O., & Lutz, M. W. (2017) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2017.1286227 · Cited by 13
Self-citation
Normal Aging and Dementia
Prendecki, M., Florczak‐Wyspianska, J., Kowalska, M., Lianeri, M., Kozubski, W. P., & Dorszewska, J. (2016) · InTech eBooks · doi:10.5772/64203 · Cited by 12
Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts
Willette, A. A., Webb, J. L., Lutz, M. W., Bendlin, B. B., Wennberg, A. M. V., Oh, J. M., Roses, A. D., Koscik, R. L., Hermann, B. P., Dowling, N. M., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.03.009 · Cited by 12
Self-citation
Analysis of cognitive performance and polymorphisms of SORL1, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU, and BIN1 in patients with mild cognitive impairment and cognitively healthy controls
Sanabria, F. C., Bonilla-Vargas, K. J., Estrada, K., Páez, O. M., Vega, E., Guerrero, E., Ortega-Rojas, J., María, F. M., Romero, A., Montañés, P., et al. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2018.07.012 · Cited by 12
TOMM40 ‘523 Associations with Baseline and Longitudinal Cognition in APOE ɛ 3 Homozygotes
Watts, A. S., Wilkins, H., Michaelis, E. K., & Swerdlow, R. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190293 · Cited by 11
The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults
Laczó, J., Čechová, K., Pařízková, M., Lerch, O., Andel, R., Maťoška, V., Kaplan, V., Matušková, V., Nedelská, Z., Vyhnálek, M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200615 · Cited by 13
TOMM40 ‘523’ poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson’s disease
Bakeberg, M. C., Gorecki, A. M., Pfaff, A. L., Hoes, M. E., Kõks, S., Akkari, P. A., Mastaglia, F. L., & Anderton, R. S. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00200-y · Cited by 10
Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding
Siddarth, P., Burggren, A. C., Merrill, D. A., Ercoli, L. M., Mahmood, Z., Barrio, J. R., & Small, G. W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208358 · Cited by 10
Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer’s Disease
Fields, T. N., Mueller, K. D., Koscik, R. L., Johnson, S. C., Okonkwo, O. C., & Litovsky, R. Y. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200701 · Cited by 10
Self-citation
TOMM40 gene polymorphisms association with lipid profile
Ринатович, С. Р., Goncharova, I. A., Makeeva, O. A., Golubenko, M. V., Кулиш, Е. В., Кашталап, В. В., Барбараш, О. Л., & Puzyrev, V. P. (2014) · Russian Journal of Genetics · doi:10.1134/s1022795413120090 · Cited by 9
Análisis de desempeños cognitivos y polimorfismos en SORL, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU y BIN1 en pacientes con trastorno neurocognitivo leve y en sujetos cognitivamente sanos
Sanabria, F. C., Bonilla-Vargas, K. J., Estrada, K., Páez, O. M., Vega, E., Guerrero, E., Ortega-Rojas, J., Mahecha, M. F., Romero, A., Montañés, P., et al. (2018) · Neurología · doi:10.1016/j.nrl.2018.07.002 · Cited by 7
Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults
Moir, M. E., Loggie, N. A., Fico, B. G., Gaynor‐Metzinger, S. H. A., Norby, A. M., Zea, R. D., Howery, A. J., Rivera‐Rivera, L. A., Eisenmenger, L. B., Wieben, O. E., et al. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00061.2025 · Cited by 6
Self-citation
Uncovering the Localization and Function of a Novel Read-Through Transcript ‘TOMM40-APOE’
Chang, S., Torii, S., Inamo, J., Ishikawa, K., Kochi, Y., & Shimizu, S. (2023) · Cells · doi:10.3390/cells13010069 · Cited by 5
The Pathogenic Component of the APOE-TOMM40 Region in Alzheimer’s disease: Its Implications in Metabolomics and Pharmacogenomics
Cacabelos, R. (2014) · Journal of Postgenomics Drug & Biomarker Development · doi:10.4172/2153-0769.1000e129 · Cited by 4
The Role of TOMM40 in Cardiovascular Mortality and Conduction Disorders: An Observational Study
Stolfo, G. D., Mastroianno, S., Soldato, N., Massaro, R. S., Luca, G. D., Seripa, D., Urbano, M., Gravina, C., Greco, A., Siena, P., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113177 · Cited by 5

Authors: Johnson, S. C., La Rue, A., Hermann, B. P., Xu, G., Koscik, R. L., Jonaitis, E. M., Bendlin, B. B., Hogan, K. J., Roses, A. D., Saunders, A. M., Lutz, M. W., Asthana, S., Green, R. C., & Sager, M. A.
Affiliations: University of Wisconsin–Madison (US)
Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA
Duke University (US)
Boston University (US)
Corresponding author: Johnson, Sterling C.
ORCID: Johnson, Sterling C.
Hermann, Bruce P.
Xu, Guofan
Koscik, Rebecca L.
Jonaitis, Erin M.
Bendlin, Barbara B.
Hogan, Kirk J.
Saunders, Ann M.
Lutz, Michael W.
Asthana, Sanjay
Green, Robert C.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2011-07
Volume: 7
Issue: 4
Pages: 456-465
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2010.11.012
PMC: PMC3143375
OpenAlex: W2085579734
Cited by: 112
References: 41
Citations by year: 2025: 4 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 16 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 14
FWCI: 7.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Helen Bader Foundation
Northwestern Mutual Foundation
Extendicare Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: TOMM40
MeSH terms: Mitochondrial Precursor Protein Import Complex Proteins, Age Factors, Alzheimer Disease, Analysis of Variance, Brain, Cognition Disorders, Female, Gene Frequency, Genotype, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Poly T, Risk Factors, Polymorphism, Single Nucleotide, Membrane Transport Proteins, Apolipoprotein E3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The effect of TOMM40 poly‐T length on gray matter volume and cognition in middle‐aged persons with APOEɛ 3/ɛ 3 genotype

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks