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MIND diet slows cognitive decline with aging
Open accessAbstract
Introduction: The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Methods: We devised the Mediterranean‐Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. Results: In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. Discussion: The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.
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“Collectively, this suggests that eating a heart-healthy diet [172,173,174,175,176] and increasing physical activity [177,178,179,180] could delay the onset of AD.”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [174]
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“In addition to physical activity, many but not all studies suggest that consuming a heart‐healthy diet may be associated with reduced dementia risk.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [136]
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“In addition to physical activity, emerging evidence suggests that consuming a heart-healthy diet may be associated with reduced dementia risk.129-134”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [131]
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Metadata
- Authors
- Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Barnes, L. L., Bennett, D. A., & Aggarwal, N. T.
- Affiliations
- Rush University Medical Center (US)
- Harvard University (US)
- Corresponding author
- Morris, Martha Clare
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2015-06-15
- Volume
- 11
- Issue
- 9
- Pages
- 1015-1022
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC4581900
- OpenAlex
- W1893987280
- Cited by
- 1,115
- References
- 54
- Citations by year
- 2026: 159 · 2025: 167 · 2024: 145 · 2023: 126 · 2022: 125 · 2021: 99 · 2020: 125 · 2019: 58 · 2018: 55 · 2017: 36 · 2016: 17 · 2015: 2
- FWCI
- 39.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute on Aging (R01AG031553, R01AG17917)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- MIND diet, cognitive decline
- MeSH terms
- Aged, 80 and over, Aging, Chicago, Cognition Disorders, Diet Surveys, Female, Humans, Male, Prospective Studies, Psychological Tests, Linear Models, Disease Progression, Diet, Mediterranean
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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