Cited by 1,115Nutritional Studies and DietDementia and Cognitive Impairment ResearchFatty Acid Research and Health

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MIND diet slows cognitive decline with aging

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Morris, Martha Clare, Tangney, Christy C., Wang, Yamin, Sacks, Frank M., Barnes, Lisa L., Bennett, David A., Aggarwal, Neelum T.·2015·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2015.04.011PMC PMC4581900

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Abstract

Introduction: The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Methods: We devised the Mediterranean‐Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. Results: In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. Discussion: The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.

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Authors: Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Barnes, L. L., Bennett, D. A., & Aggarwal, N. T.
Affiliations: Rush University Medical Center (US)
Harvard University (US)
Corresponding author: Morris, Martha Clare
ORCID: Morris, Martha Clare
Tangney, Christy C.
Wang, Yamin
Sacks, Frank M.
Barnes, Lisa L.
Bennett, David A.
Aggarwal, Neelum T.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2015-06-15
Volume: 11
Issue: 9
Pages: 1015-1022
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2015.04.011
PMC: PMC4581900
OpenAlex: W1893987280
Cited by: 1,115
References: 54
Citations by year: 2026: 159 · 2025: 167 · 2024: 145 · 2023: 126 · 2022: 125 · 2021: 99 · 2020: 125 · 2019: 58 · 2018: 55 · 2017: 36 · 2016: 17 · 2015: 2
FWCI: 39.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institute on Aging (R01AG031553, R01AG17917)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: MIND diet, cognitive decline
MeSH terms: Aged, 80 and over, Aging, Chicago, Cognition Disorders, Diet Surveys, Female, Humans, Male, Prospective Studies, Psychological Tests, Linear Models, Disease Progression, Diet, Mediterranean

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