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MIND diet slows cognitive decline with aging
Open accessAbstract
Introduction: The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Methods: We devised the Mediterranean‐Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. Results: In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. Discussion: The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.
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“Collectively, this suggests that eating a heart-healthy diet [172,173,174,175,176] and increasing physical activity [177,178,179,180] could delay the onset of AD.”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [174]
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“In addition to physical activity, many but not all studies suggest that consuming a heart‐healthy diet may be associated with reduced dementia risk.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [136]
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“In addition to physical activity, emerging evidence suggests that consuming a heart-healthy diet may be associated with reduced dementia risk.129-134”
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Metadata
- Authors
- Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Barnes, L. L., Bennett, D. A., & Aggarwal, N. T.
- Affiliations
- Rush University Medical Center (US)
- Harvard University (US)
- Corresponding author
- Morris, Martha Clare
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2015-06-15
- Volume
- 11
- Issue
- 9
- Pages
- 1015-1022
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC4581900
- OpenAlex
- W1893987280
- Cited by
- 1,115
- References
- 54
- Citations by year
- 2026: 159 · 2025: 167 · 2024: 145 · 2023: 126 · 2022: 125 · 2021: 99 · 2020: 125 · 2019: 58 · 2018: 55 · 2017: 36 · 2016: 17 · 2015: 2
- FWCI
- 39.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute on Aging (R01AG031553, R01AG17917)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- MIND diet, cognitive decline
- MeSH terms
- Aged, 80 and over, Aging, Chicago, Cognition Disorders, Diet Surveys, Female, Humans, Male, Prospective Studies, Psychological Tests, Linear Models, Disease Progression, Diet, Mediterranean
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