Cited by 885Dementia and Cognitive Impairment ResearchHealth disparities and outcomesAlzheimer's disease research and treatments

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Inequalities in dementia incidence between six racial and ethnic groups over 14 years

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Mayeda, Elizabeth Rose, Glymour, M.Maria, Quesenberry, Charles P., Whitmer, Rachel A.·2016·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2015.12.007PMC PMC4969071

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Abstract

Introduction: Reducing racial/ethnic disparities is a primary objective of the National Alzheimer's Plan (NAPA), yet direct comparisons within large samples representing diversity of the United States are lacking. Methods: Dementia incidence from January 1, 2000 to December 31, 2013 and a 25‐year cumulative risk in 274,283 health care members aged 64+ (n = 18,778 African‐American, n = 4543 American Indian/Alaska Native [AIAN], n = 21,000 Latino, n = 440 Pacific Islander, n = 206,490 white, n = 23,032 Asian‐Americans). Cox proportional hazard models were adjusted for age, sex, medical utilization, and comorbidities. Results: Dementia incidence (n = 59,555) was highest for African‐Americans (26.6/1000 person‐years) and AIANs (22.2/1000 person‐years); intermediate for Latinos (19.6/1000 person‐years), Pacific Islanders (19.6/1000 person‐years), and whites (19.3/1000 person‐years) and lowest among Asian‐Americans (15.2/1000 person‐years). Risk was 65% greater for African‐Americans (hazard ratio = 1.65; 95% confidence interval = 1.58–1.72) versus Asian‐Americans. Cumulative 25‐year risk at age 65 was as follows: 38% African‐Americans, 35% AIANs, 32% Latino, 25% Pacific Islanders, 30% white, and 28% Asian‐Americans. Discussion: Dementia rates varied over 60% between groups, providing a comprehensive benchmark for the NAPA goal of reducing disparities.

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Authors: Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., & Whitmer, R. A.
Affiliations: University of California, San Francisco (US)
Kaiser Permanente (US)
Corresponding author: Whitmer, Rachel A.
ORCID: Mayeda, Elizabeth Rose
Glymour, M.Maria
Quesenberry, Charles P.
Whitmer, Rachel A.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2016-02-10
Volume: 12
Issue: 3
Pages: 216-224
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2015.12.007
PMC: PMC4969071
OpenAlex: W2266863819
Cited by: 883
References: 51
Citations by year: 2026: 98 · 2025: 109 · 2024: 112 · 2023: 113 · 2022: 113 · 2021: 100 · 2020: 96 · 2019: 66 · 2018: 41 · 2017: 27 · 2016: 7
FWCI: 41.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Aging
National Institutes of Health
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Health › Health disparities and outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: dementia incidence, racial and ethnic disparities
MeSH terms: Age Factors, Aged, Aged, 80 and over, Black or African American, Delivery of Health Care, Dementia, Ethnicity, Female, Hispanic or Latino, Humans, Indians, North American, Longitudinal Studies, Male, Middle Aged, Sex Factors, Socioeconomic Factors, United States, Incidence, Proportional Hazards Models, White People

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Inequalities in dementia incidence between six racial and ethnic groups over 14 years

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