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Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
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During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this “silent” stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.
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“This could explain why part of the risk factors for cardiovascular disease are in common with AD, including hypertension, dyslipidemia, diabetes, obesity, dietary factors, smoking, and physical activity (Figure 1B).”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [22]
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“Thus, lifestyle is also an important risk factor, where intellectual, physical, and social activities, as well as diet, may help to prevent AD [1,22,100,101,102,103].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [22]
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“Thus, the disease is now regarded as a continuum rather than three distinct clinically defined entities [15].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [15]
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“While differences remain, IWG 2016 and the NIA research framework are aligned on the key issue that the combination of an abnormal Aβ and tau biomarker constitutes AD regardless of cognitive symptoms, and thus AD is a biologically defined entity throughout its continuum.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [15]
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“Furthermore, drug development research for AD has become more complicated as preclinical and prodromal AD populations are potentially included in current trials, as well as traditionally included populations of all the clinical stages of AD dementia.38”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [38]
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“Although the use of clinical trial simulators is not frequent in recent research,38”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [38]
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“This asymptomatic phase of AD (AsymAD) is currently considered a preclinical stage of the disease [27, 28].”
From Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease (2018) · cites this paper as [27]
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Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 1×
“From the tau protein perspective, one study showed that alterations in CSF levels of p-tau may precede those of Ab [57], which correlates with postmortem evidence showing the presence of neurofibrillary tangles in the entorhinal cortex and in hippocampal-related structures [58,59] as the first neuropathologic event in…”
ResultCorder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationBiomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Self-citationJack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citationMeta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citationClinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
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Items 701–800 of 1,003
Neuropathology‐based APOE genetic risk score better quantifies Alzheimer's risk
Deming, Y. K., Vasiljevic, E., Morrow, A. R., Miao, J., Hulle, C. V., Jonaitis, E. M., Ma, Y., Whitenack, V. M., Kollmorgen, G., Wild, N., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12990 · Cited by 22
Self-citationDakterzada, F., Jové, M., Huerto, R. P., Carnes, A., Sol, J., Pamplona, R., & Piñol‐Ripoll, G. (2023) · Aging and Disease · doi:10.14336/ad.2023.0221 · Cited by 22
González‐Ortiz, F., Karikari, T. K., Bentivenga, G. M., Baiardi, S., Mammana, A., Turton, M., Kac, P. R., Mastrangelo, A., Harrison, P., Capellari, S., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13516 · Cited by 22
Self-citationLehrner, J. P., Coutinho, G., Mattos, P., Moser, D., Pflüger, M., Gleiß, A., Auff, E., Dal‐Bianco, P., Pußwald, G., & Stögmann, E. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000394 · Cited by 22
Þórðardóttir, S., Rodriguez‐Vieitez, E., Almkvist, O., Ferreira, D., Saint‐Aubert, L., Ståhlbom, A. K., Thonberg, H., Schöll, M., Westman, E., Wall, A. E., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0374-y · Cited by 23
Self-citationEvolución histórica del concepto y criterios actuales para el diagnóstico de demencia.
Custodio, N., Montesinos, R., & Alarcón, J. O. (2019) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v81i4.3438 · Cited by 38
Good, T. J., Villafuerte, J. W., Ryan, J. D., Grady, C. L., & Barense, M. D. (2020) · eNeuro · doi:10.1523/eneuro.0290-19.2020 · Cited by 22
Tülay, E. E., Güntekin, B., Yener, G., Bayram, A., Başar‐Eroğlu, C., & Demıralp, T. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.06.001 · Cited by 22
Moreira, S. C., Jansen, A. K., & Silva, F. M. (2020) · Dementia & Neuropsychologia · doi:10.1590/1980-57642020dn14-030008 · Cited by 23
Wang, S., Sun, H., Hu, G., Xue, C., Qi, W., Rao, J., Zhang, F., Zhang, X., & Chen, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.597455 · Cited by 22
Eckerström, C., Svensson, J., Kettunen, P., Jonsson, M. A. G., & Eckerström, M. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12031 · Cited by 22
Artificial Intelligence in Medicine
Salvatore, C., Battista, P., & Castiglioni, I. (2020) · Wiley eBooks · doi:10.1002/9781119057840.ch19 · Cited by 22
Huang, Y., Chen, H., Gao, M., Lv, X., Pang, T., Rong, S., Xu, X., & Yuan, C. (2024) · BMC Medicine · doi:10.1186/s12916-023-03147-4 · Cited by 21
Enache, D., Pereira, J. B., Jelić, V., Winblad, B. G., Nilsson, P., Aarsland, D., & Bereczki, E. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200498 · Cited by 23
Longitudinal predictive modeling of tau progression along the structural connectome
Yang, F., Chowdhury, S. R., Jacobs, H. I. L., Sepulcre, J., Wedeen, V. J., Johnson, K. A., & Dutta, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118126 · Cited by 24
Petersen, N., & Schicktanz, S. (2021) · Qualitative Health Research · doi:10.1177/10497323211014844 · Cited by 21
Li, L., Yang, Y., Zhang, Q., Wang, J., Jiang, J., & Initiative, A. D. N. (2021) · Behavioural Neurology · doi:10.1155/2021/3359103 · Cited by 22
Taylor, M., Sullivan, D. K., Morris, J. K., Vidoni, E. D., Honea, R. A., Mahnken, J. D., & Burns, J. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.741534 · Cited by 28
Episodic Memory Impairment Mediates the Loss of Awareness in Mild Cognitive Impairment
Gagliardi, G. P., & Vannini, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.802501 · Cited by 21
Torkpoor, R., Fioretos, I., Essén, B., & Londos, E. (2022) · Journal of Cross-Cultural Gerontology · doi:10.1007/s10823-021-09439-7 · Cited by 21
Watanabe, S., Omran, A. J. A., Shao, A. S., Chen, X., Zhang, Z., Zhang, J., Davies, D. L., Shao, X. M., Watanabe, J., & Liang, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-09814-5 · Cited by 23
Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease
Yener, G., Gündüz, D. H., Yıldırım, E., Aktürk, T., Başar‐Eroğlu, C., Bonanni, L., Percio, C. D., Farina, F. R., Ferri, R., Güntekin, B., et al. (2022) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2022.05.008 · Cited by 21
Short-term memory conjunctive binding in Alzheimer’s disease: A systematic review and meta-analysis.
Cecchini, M. A., Parra, M. A., Brazzelli, M. G., Logie, R. H., & Sala, S. D. (2022) · Neuropsychology · doi:10.1037/neu0000825 · Cited by 21
Individualized diagnosis of preclinical Alzheimer’s Disease using deep neural networks
Park, J., Jang, S., Gwak, J., Kim, B. C., Lee, J. J., Choi, K. Y., Lee, K. H., Jun, S. C., Jang, G., & Ahn, S. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.118511 · Cited by 22
Boccardi, V., Poli, G., Cecchetti, R., Bastiani, P., Scamosci, M., Febo, M., Mazzon, E., Bruscoli, S., Brancorsini, S., & Mecocci, P. (2023) · Nutrients · doi:10.3390/nu15030634 · Cited by 21
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25
Sandison, H., Callan, N. G. L., Rao, R. V., Phipps, J. C., & Bradley, R. D. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230004 · Cited by 25
Joshi, R., Missong, H., Mishra, J., Kaur, S., Saini, S., Kandimalla, R. J. L., Reddy, P. H., Babu, A. M., Bhatti, G. K., & Bhatti, J. S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105067 · Cited by 23
Grammatikopoulou, M., Lazarou, I., Alepopoulos, V., Mpaltadoros, L., Oikonomou, V. P., Stavropoulos, T. G., Nikolopoulos, S., Kompatsiaris, I. Y., & Tsolaki, M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1375131 · Cited by 21
Haniff, Z. R., Bocharova, M., Mantingh, T., Rucker, J., Velayudhan, L., Taylor, D. M., Young, A. H., Aarsland, D., Vernon, A. C., & Thuret, S. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108641 · Cited by 21
Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer’s Disease
Yang, Y., & Qiu, L. (2024) · Brain Sciences · doi:10.3390/brainsci14060590 · Cited by 22
Riphagen, J. M., Gronenschild, E. H. B. M., Salat, D. H., Freeze, W. M., Ivanov, D., Clerx, L., Verhey, F. R. J., Aalten, P., & Jacobs, H. I. L. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.029 · Cited by 21
de Boer, C., Echlin, H. V., Rogojin, A., Baltaretu, B. R., & Sergio, L. E. (2018) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000490173 · Cited by 21
Sánchez‐Benavides, G., Grau‐Rivera, O., Cacciaglia, R., Suárez‐Calvet, M., Falcón, C., Minguillón, C., Gramunt, N., Sala‐Vila, A., Gispert, J. D., & Molinuevo, J. L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180378 · Cited by 21
Self-citationBrinkmalm, A., Portelius, E., Brinkmalm, G., Pannee, J., Dahlén, R., Gobom, J., Blennow, K., & Zetterberg, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14594 · Cited by 23
Self-citationTherapeutic potential of targeting mixed lineage kinases in cancer and inflammation
Gallo, K. A., Ellsworth, E. L., Stoub, H., & Conrad, S. E. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107457 · Cited by 21
Lee, B., Kim, M., Lee, S. Y., Son, S. J., Hong, C. H., & Jung, Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061642 · Cited by 21
Multifactorial 10-Year Prior Diagnosis Prediction Model of Dementia
Dallora, A. L., Minku, L. L., Mendes, E., Rennemark, M., Anderberg, P., & Berglund, J. S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186674 · Cited by 21
Milà‐Alomà, M., Salvadó, G., Shekari, M., Grau‐Rivera, O., Sala‐Vila, A., Sánchez‐Benavides, G., Arenaza‐Urquijo, E. M., Gónzalez‐de‐Echávarri, J. M., Simon, M., Kollmorgen, G., et al. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.51 · Cited by 22
Self-citationMukherji, D., Mukherji, M., Mukherji, N., & Initiative, A. D. N. (2022) · Brain Informatics · doi:10.1186/s40708-022-00169-1 · Cited by 23
What have we learnt from past failures in Alzheimer’s disease drug discovery?
Cacabelos, R. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2033724 · Cited by 22
Souvenaid for Alzheimer's disease
Burckhardt, M., Watzke, S., Wienke, A., Langer, G., & Fink, A. M. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011679.pub2 · Cited by 19
Werner, P., Ulitsa, N., Shefet, D., AboJabel, H., Alpinar-Şencan, Z., & Schicktanz, S. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220003397 · Cited by 21
An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases
Wang, T., Ashrafi, A., Modareszadeh, P., Deese, A. R., Castro, M. D. C. C., Alemi, P. S., & Li, Z. (2021) · Cancers · doi:10.3390/cancers13164142 · Cited by 20
Motovylyak, A., Vogt, N. M., Adluru, N., Ma, Y., Wang, R., Oh, J. M., Kecskemeti, S., Alexander, A. L., Dean, D., Gallagher, C. L., et al. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100030 · Cited by 23
Cheah, W.-T., Hwang, J.-J., Hong, S.-Y., Fu, L., Chang, Y., Chen, T., Chen, I.-A., & Chou, C.-C. (2022) · JMIR Medical Informatics · doi:10.2196/31106 · Cited by 20
Sheng, C., Yang, K. Y., He, B., Li, T., Wang, X., Du, W., Hu, X., Jiang, J., Jiang, X., Jessen, F., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215452 · Cited by 19
Zuroff, L. R., Wisse, L. E. M., Glenn, T. W., Xie, S. X., Nasrallah, I. M., Habes, M., Dubroff, J. G., de Florès, R., Xie, L., Yushkevich, P. A., et al. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220013 · Cited by 22
Caprioglio, C., Garibotto, V., Jessen, F., Frölich, L., Allali, G., Assal, F., Frisoni, G. B., & Altomare, D. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220333 · Cited by 20
Self-citationProteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment
Chen, B., Song, L., Yang, J., Zhou, W., Cheng, Y., & Lai, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.347740 · Cited by 20
Funane, T., Jun, H., Sutoko, S., Saido, T. C., Kandori, A., & Igarashi, K. M. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.955178 · Cited by 19
Preclinical Alzheimer’s dementia: a useful concept or another dead end?
Mark, R. E., & Brehmer, Y. (2022) · European Journal of Ageing · doi:10.1007/s10433-022-00735-w · Cited by 20
Modulation of microRNAs through Lifestyle Changes in Alzheimer’s Disease
Pinto-Hernandez, P., Castilla-Silgado, J., Coto-Vilcapoma, A., Fernández-Sanjurjo, M., Fernández-García, B., Tomás-Zapico, C., & Iglesias-Gutiérrez, E. (2023) · Nutrients · doi:10.3390/nu15173688 · Cited by 22
Huang, X., Huang, S., Fu, F., Song, J., Zhang, Y., & Yue, F. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01416-9 · Cited by 23
Neurophysiological trajectories in Alzheimer’s disease progression
Kudo, K., Ranasinghe, K. G., Morise, H., Syed, F., Sekihara, K., Rankin, K. P., Miller, B. L., Kramer, J. H., Rabinovici, G. D., Vossel, K. A., et al. (2023) · eLife · doi:10.7554/elife.91044 · Cited by 31
Self-citationSong, B., Yoshida, S., & Initiative, A. D. N. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303278 · Cited by 20
Wang, X., Xie, Y., Fan, X., Wu, X., Wang, D., & Li, Z. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01489-6 · Cited by 26
Abulafia, C., Duarte-Abritta, B., Villarreal, M. F., Ladrón-de-Guevara, M. S., García, C., Sequeyra, G., Sevlever, G. E., Fiorentini, L., Bär, K., Gustafson, D., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00093 · Cited by 20
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Lu, P. H., & Lee, G. J. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.002 · Cited by 20
Molinuevo, J. L., Minguillón, C., Rami, L., & Gispert, J. D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170698 · Cited by 21
Self-citationSummers, M. J., Rainero, I., Vercelli, A., Aumayr, G., Rosario, H. D., Mönter, M., Kawashima, R., Vercelli, A. E., Rainero, I., Caglio, M., et al. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.004 · Cited by 20
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Wısnıewskı, T., & Drummond, E. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.08.001 · Cited by 20
Muñoz‐Moreno, E., Tudela, R., López-Gil, X., & Sòria, G. (2020) · Network Neuroscience · doi:10.1162/netn_a_00126 · Cited by 18
Ghaffari, M. S., Sanadgol, N., & Abdollahi, M. R. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666200513122357 · Cited by 20
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Segovia, F., Gómez-Río, M. M., Sánchez-Vañó, R., Górriz, J. M., Ramı́rez, J., Triviño‐Ibáñez, E. M., Pardo, C. C., Martinez-Lozano, M. D., & Sopena‐Novales, P. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180232 · Cited by 19
Elhage, A., Cohen, S., Cummings, J. L., van der Flier, W. M., Aisen, P. S. S., Cho, M., Bell, J., & Hampel, H. J. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14425 · Cited by 21
Self-citationHtun, H. L., Teshale, A. B., Ryan, J. L., Owen, A. J., Chong, T. T. ‐., Orchard, S. G., Murray, A. M., Shah, R. C., Woods, R. L., & Freak‐Poli, R. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70065 · Cited by 19
Kaur, A., & Aran, K. R. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.001 · Cited by 23
Salardini, A., Himali, J. J., Abdullah, M. S., Chaudhari, R., Young, V. M., Zilli, E. M., McGrath, E. R., Gonzales, M. M., Thibault, E. G., Salinas, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70179 · Cited by 21
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Tresker, S. (2020) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/j.shpsc.2020.101291 · Cited by 22
Vaqué‐Alcázar, L., Mulet‐Pons, L., Abellaneda‐Pérez, K., Solé‐Padullés, C., Cabello‐Toscano, M. R., Macià, D., Sala‐Llonch, R., Bargalló, N., Sánchez, J. S., Cattaneo, G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.695232 · Cited by 21
Weighted Brain Network Analysis on Different Stages of Clinical Cognitive Decline
Abazid, M., Houmani, N., Dorizzi, B., Boudy, J., Mariani, J., & Kinugawa, K. (2022) · Bioengineering · doi:10.3390/bioengineering9020062 · Cited by 20
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Self-citation
Metadata
- Authors
- Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., Broich, K., Cavedo, E., Crutch, S., Dartigues, J., Duyckaerts, C., Epelbaum, S., Frisoni, G. B., Gauthier, S., Genthon, R., Gouw, A. A., Habert, M., Holtzman, D. M., Kivipelto, M., Lista, S., Molinuevo, J., O'Bryant, S. E., Rabinovici, G. D., Rowe, C., Salloway, S., Schneider, L. S., Sperling, R., Teichmann, M., Carrillo, M. C., Cummings, J., Jack, C. R., & Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2. W. D.
- Affiliations
- Sorbonne Université (FR)
- University of British Columbia (CA)
- Amsterdam Neuroscience (NL)
- University of Southern California (US)
- Université Toulouse III - Paul Sabatier (FR)
- Institut du Cerveau (FR)
- Centre National de la Recherche Scientifique (FR)
- Institute for Integrative and Experimental Genomics (DE)
- Sahlgrenska University Hospital (SE)
- Federal Institute for Drugs and Medical Devices (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- UCL Queen Square Institute of Neurology (GB)
- Université de Bordeaux (FR)
- University of Geneva (CH)
- Douglas Mental Health University Institute (CA)
- Fondation pour la Recherche sur Alzheimer Hôpital Pitié‐Salpêtrière Paris France
- Washington University in St. Louis (US)
- Karolinska University Hospital (SE)
- AXA Research Fund (FR)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
- Center for Alzheimer's & Neurodegenerative Disease Research University of North Texas Health Science Center TX USA
- University of California, San Francisco (US)
- The University of Melbourne (AU)
- Brown University (US)
- Brigham and Women's Hospital (US)
- The Alzheimer's Association Division of Medical & Scientific Relations Chicago USA
- Cleveland Clinic (US)
- Department of Radiology Mayo Clinic Rochester MN USA
- Corresponding author
- Dubois, Bruno
- ORCID
- Dubois, Bruno
- Hampel, Harald
- Feldman, Howard H.
- Scheltens, Philip
- Andrieu, Sandrine
- Bakardjian, Hovagim
- Benali, Habib
- Bertram, Lars
- Blennow, Kaj
- Broich, Karl
- Cavedo, Enrica
- Crutch, Sebastian
- Dartigues, Jean‐François
- Duyckaerts, Charles
- Epelbaum, Stéphane
- Frisoni, Giovanni B.
- Gauthier, Serge
- Gouw, Alida A.
- Habert, Marie‐Odile
- Holtzman, David M.
- Kivipelto, Miia
- Lista, Simone
- Rabinovici, Gil D.
- Rowe, Christopher
- Salloway, Stephen
- Schneider, Lon S.
- Sperling, Reisa
- Teichmann, Marc
- Cummings, Jeffrey
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2016-03
- Volume
- 12
- Issue
- 3
- Pages
- 292-323
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6417794
- OpenAlex
- W2309442902
- Cited by
- 1,925
- References
- 298
- Citations by year
- 2026: 115 · 2025: 176 · 2024: 244 · 2023: 245 · 2022: 247 · 2021: 244 · 2020: 176 · 2019: 157 · 2018: 161 · 2017: 112 · 2016: 47
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- AXA Research Fund
- National Institute on Aging
- Alzheimer's Association
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- preclinical Alzheimer's disease, Alzheimer's disease continuum
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Disease Progression
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