The DOI matches its Crossref record; 298 of the 298 references it cites were found in a registry or an index.
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Open accessAbstract
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this “silent” stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This could explain why part of the risk factors for cardiovascular disease are in common with AD, including hypertension, dyslipidemia, diabetes, obesity, dietary factors, smoking, and physical activity (Figure 1B).”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [22]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Thus, lifestyle is also an important risk factor, where intellectual, physical, and social activities, as well as diet, may help to prevent AD [1,22,100,101,102,103].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [22]
The cited source says what the claim attributes to it.
In the citing paper
“Thus, the disease is now regarded as a continuum rather than three distinct clinically defined entities [15].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [15]
The cited source says what the claim attributes to it.
In the citing paper
“While differences remain, IWG 2016 and the NIA research framework are aligned on the key issue that the combination of an abnormal Aβ and tau biomarker constitutes AD regardless of cognitive symptoms, and thus AD is a biologically defined entity throughout its continuum.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [15]
In the citing paper
“Furthermore, drug development research for AD has become more complicated as preclinical and prodromal AD populations are potentially included in current trials, as well as traditionally included populations of all the clinical stages of AD dementia.38”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [38]
In the citing paper
“Although the use of clinical trial simulators is not frequent in recent research,38”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [38]
In the citing paper
“This asymptomatic phase of AD (AsymAD) is currently considered a preclinical stage of the disease [27, 28].”
From Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease (2018) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 1×
“From the tau protein perspective, one study showed that alterations in CSF levels of p-tau may precede those of Ab [57], which correlates with postmortem evidence showing the presence of neurofibrillary tangles in the entorhinal cortex and in hippocampal-related structures [58,59] as the first neuropathologic event in…”
ResultCorder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationBiomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Self-citationJack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citationMeta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citationClinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 1,003
Sheng, C., Yang, K. Y., Wang, X., Li, H., Li, T., Li, L., Liu, Y. F., Yang, Q. Z., Wang, X., Wang, X., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191295 · Cited by 41
Progress on early diagnosing Alzheimer’s disease
Chen, Y., Al‐Nusaif, M., Li, S., Tan, X., Yang, H., Cai, H., & Le, W. (2024) · Frontiers of Medicine · doi:10.1007/s11684-023-1047-1 · Cited by 44
Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research
Bieger, A., Brum, W. S., Borelli, W. V., Therriault, J., Bastiani, M. A. D., Moreira, A. G., Benedet, A. L., Ferrari‐Souza, J. P., da Costa, J. C., Souza, D. O., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000209753 · Cited by 35
Self-citationdel Val, L. P., Cantero, J. L., & Atienza, M. (2016) · Scientific Reports · doi:10.1038/srep31859 · Cited by 33
Zhu, F., Panwar, B., Dodge, H. H., Li, H., Hampstead, B. M., Albin, R. L., Paulson, H. L., & Guan, Y. (2016) · Scientific Reports · doi:10.1038/srep34567 · Cited by 34
Subjective Cognitive Decline and Nighttime Sleep Alterations, a Longitudinal Analysis
Bubbico, G., Iorio, A. D., Lauriola, M., Sepede, G., Salice, S., Spina, E., Brondi, G., Esposito, R., Perrucci, M. G., & Tartaro, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00142 · Cited by 36
Taylor, J. L., Hambro, B. C., Strossman, N. D., Bhatt, P., Hernandez, B., Ashford, J. W., Cheng, J. J., Iv, M., Adamson, M. M., Lazzeroni, L. C., et al. (2019) · BMC Neurology · doi:10.1186/s12883-019-1552-7 · Cited by 35
Liang, L., Yuan, Y., Wei, Y., Yu, B., Mai, W., Duan, G., Nong, X., Li, C., Su, J., Zhao, L., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00764-6 · Cited by 34
Kim, J. H., Jung, H., Lee, Y., & Sohn, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.658860 · Cited by 33
Liang, P.-Z., Li, L., Zhang, Y., Shen, Y. H., Zhang, L., Zhou, J., Wang, Z.-J., Wang, S., & Yang, S. (2021) · Neural Plasticity · doi:10.1155/2021/9960304 · Cited by 34
Ivanova, O., Meilán, J. J. G., Martínez‐Sánchez, F., Martínez‐Nicolás, I., Llorente, T. E., & Carcavilla-González, N. (2021) · Computer Speech & Language · doi:10.1016/j.csl.2021.101341 · Cited by 35
Lee, B., Yao, X., Shen, L., & Initiative, A. D. N. (2022) · BMC Genomics · doi:10.1186/s12864-022-08584-8 · Cited by 34
Liquid-liquid phase separation in Alzheimer’s disease
Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33
Review on Alzheimer’s disease: past, present and future
Rayathala, J., Kiran Kumar, C., & Venkatesh, P. (2022) · Journal of Innovations in Applied Pharmaceutical Science (JIAPS) · doi:10.37022/jiaps.v7i1.274 · Cited by 32
Roth, S., Burnie, N., Suridjan, I., Yan, J. T., & Carboni, M. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr230007 · Cited by 32
Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
Milicic, L., Porter, T., Vacher, M. A., & Laws, S. M. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220109 · Cited by 36
Bermejo‐Pareja, F., & del Ser, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020536 · Cited by 39
Association of cerebrospinal fluid Neurogranin with Alzheimer’s disease
Initiative, A. D. N., & Wang, L. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0948-3 · Cited by 32
Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease
Conwell, K., von Reutern, B., Richter, N., Kukolja, J., Fink, G. R., & Onur, O. A. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.06.016 · Cited by 32
Chand, G. B., Hajjar, I. M., & Qiu, D. (2018) · Human Brain Mapping · doi:10.1002/hbm.24339 · Cited by 28
Sharma, H. S., Muresanu, D. F., Nozari, A., Lafuente, J. V., Tian, Z. R., Ozkızılcık, A., Manzhulo, I., Mössler, H., & Sharma, A. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.009 · Cited by 33
Lohmeyer, J. L., Alpinar-Şencan, Z., & Schicktanz, S. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1727851 · Cited by 32
Genetic Variants and Oxidative Stress in Alzheimer’s Disease
Kowalska, M., Wize, K., Prendecki, M., Lianeri, M., Kozubski, W. P., & Dorszewska, J. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200224121447 · Cited by 34
Caruso, G. I., Spampinato, S. F., Costantino, G., Merlo, S., & Sortino, M. A. (2021) · Biomedicines · doi:10.3390/biomedicines9050466 · Cited by 35
Cui, L., Zhang, Z., Lo, C. Z., & Guo, Q. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.684918 · Cited by 33
López‐Cuenca, I., Salobrar‐García, E., Elvira‐Hurtado, L., Fernández‐Albarral, J. A., Sánchez-Puebla, L., Salazar, J. J., Ramirez, J. M., Ramirez, A. I., & de Hoz, R. (2021) · Life · doi:10.3390/life11070712 · Cited by 36
Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid
Kim, J. Y., Mo, H., Kim, J., Kim, J. W., Nam, Y., Rim, Y. A., & Ju, J. H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.816174 · Cited by 33
Kodishala, C., Hulshizer, C. A., Kronzer, V. L., Davis, J. M., Ramanan, V. K., Vassilaki, M. E., Mielke, M. M., Crowson, C. S., & Myasoedova, E. (2022) · The Journal of Rheumatology · doi:10.3899/jrheum.220200 · Cited by 33
iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia
Li, L., Roh, J. H., Chang, E. H., Lee, Y. K., Lee, S., Kim, M., Koh, W., Chang, J. W., Kim, H. J., Nakanishi, M., et al. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.5.350 · Cited by 32
Perrotte, M., Page, A. Y. L., Fournet, M., Sayec, M. L., Rassart, É., Fülöp, T., & Ramassamy, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.452 · Cited by 33
Sakr, F. A., Grothe, M. J., Cavedo, E., Jelistratova, I., Habert, M., Dyrba, M., González‐Escamilla, G., Bertin, H., Locatelli, M., Lehéricy, S., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0466-3 · Cited by 32
Self-citationBae, S., Lee, S., Harada, K., Makino, K., Chiba, I., Katayama, O., Shinkai, Y., Park, H., & Shimada, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051424 · Cited by 31
Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives
Ramusino, M. C., Perini, G., Altomare, D., Barbarino, P., Weidner, W. S., Porro, G. S., Barkhof, F., Rabinovici, G. D., van der Flier, W. M., Frisoni, G. B., et al. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05187-x · Cited by 31
Self-citationGenetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review
Vogrinc, D., Goričar, K., & Dolžan, V. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646901 · Cited by 32
Late combination shows that MEG adds to MRI in classifying MCI versus controls
Vaghari, D., Kabir, E., & Henson, R. N. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119054 · Cited by 37
Tanninen, S. E., Nouriziabari, B., Morrissey, M. D., Bakir, R., Dayton, R. D., Klein, R. L., & Takehara‐Nishiuchi, K. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.024 · Cited by 32
Quevenco, F. C., Schreiner, S. J., Preti, M. G., Bergen, J. M. G. V., Kirchner, T., Wyss, M. T., Steininger, S. C., Gietl, A. F., Leh, S. E., Buck, A., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101776 · Cited by 31
A new perspective on Alzheimer’s disease: m6A modification
Xia, L., Zhang, F., Li, Y., Mo, Y., Zhang, L., Li, Q., Luo, M., Hou, X., Du, Z., Deng, J., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1166831 · Cited by 32
Munir, R., Zia‐ur‐Rehman, M., Murtaza, S., Zaib, S., Javid, N., Awan, S. J., Iftikhar, K., Athar, M., & Khan, I. A. (2021) · Molecules · doi:10.3390/molecules26030656 · Cited by 31
Barrett-Young, A., Ambler, A. P., Cheyne, K. R., Guiney, H., Kokaua, J., Steptoe, B., Tham, Y. C., Wilson, G., Wong, T. Y., & Poulton, R. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2021.6082 · Cited by 31
Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer’s disease
Wang, Y., Wang, Y., Zhu, J., Guan, Y., Xie, F., Cai, X., Deng, J., Wei, Y., He, R., Fang, Z., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1046066 · Cited by 33
Zheng, J., Liang, K., Wang, X., Zhou, X., Sun, J., & Zhou, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0181-z · Cited by 31
Granger, M. W., Liu, H., Fowler, C., Blanchard, A. P., Taylor, M. W., Sherman, S., Xu, H., Le, W., & Bennett, S. A. L. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14560 · Cited by 32
Arias, J. J., Tyler, A. M., Oster, B. J., & Karlawish, J. H. (2018) · The Journal of Law Medicine & Ethics · doi:10.1177/1073110518782955 · Cited by 31
Blennow, K., Stomrud, E., Zetterberg, H., Borlinghaus, N., Corradini, V., Manuilova, E., Müller-Hübner, L., Quevenco, F.-C., Rutz, S., & Hansson, O. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0516 · Cited by 30
Self-citationTobeh, N. S., & Bruce, K. D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1259012 · Cited by 35
Advancing nutrition science to meet evolving global health needs
Neufeld, L. M., Ho, E., Obeid, R., Tzoulis, C., Green, M., Huber, L. G., Stout, M., & Griffiths, J. C. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03276-9 · Cited by 40
Olfactory Dysfunction and Alzheimer’s Disease: A Review
McLaren, A., & Kawaja, M. D. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231377 · Cited by 35
Atri, A., Dickerson, B. C., Clevenger, C. K., Karlawish, J. H., Knopman, D. S., Lin, P., Norman, M., Onyike, C. U., Sano, M., Scanland, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14335 · Cited by 37
Self-citationSeo, E. H., Kim, H., Choi, K. Y., Lee, K. H., & Choo, I. H. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.07.29.1 · Cited by 30
Xie, Y., Liu, T., Ai, J., Chen, D., Zhuo, Y., Zhao, G., Shuai, H., Wu, J., Han, Y., & Yan, T. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00118 · Cited by 30
Huang, P., Zheng, N., Zhou, H., & Huang, J. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03638-0 · Cited by 31
Ricci, M., Cimini, A., Chiaravalloti, A., Filippi, L., & Schillaci, O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207481 · Cited by 33
Forcano, L., Fauria, K., Soldevila‐Domenech, N., Minguillón, C., Lorenzo, T., Cuenca‐Royo, A., Menezes‐Cabral, S., Pizarro, N., Boronat, A., Molinuevo, J. L., et al. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12155 · Cited by 30
Self-citationPersonalizing the Care and Treatment of Alzheimer’s Disease: An Overview
Štrac, D. Š., Konjevod, M., Šagud, M., Perković, M. N., Erjavec, G. N., Vuić, B., Šimić, G., Vukić, V., Mimica, N., & Pivac, N. (2021) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s284615 · Cited by 30
ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina
Cao, K., Kim, J. H., Kroeger, H., Gaffney, P. M., Lin, J. H., Sigurdson, C. J., & Yang, J. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.7.5 · Cited by 29
Song, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810223 · Cited by 30
Alzheimer’s disease: The role of T lymphocytes in neuroinflammation and neurodegeneration
Asamu, M. O., Oladipo, O. O., Abayomi, O. A., & Adebayo, A. A. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148589 · Cited by 32
The current status of blood epigenetic biomarkers for dementia
Fransquet, P., & Ryan, J. L. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1639129 · Cited by 30
Vaghari, D., Bruña, R., Hughes, L. E., Nesbitt, D. J., Tibon, R., Rowe, J. B., Maestú, F., & Henson, R. N. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119344 · Cited by 38
Čepukaitytė, G., Newton, C., & Chan, D. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13716 · Cited by 33
Odusami, M., Damaševičius, R., Belousovienė, E., & Maskeliūnas, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34402 · Cited by 30
Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Guo, Q. J., Ping, L., Dammer, E. B., Duong, D. M., Yin, L., Xu, K., Shantaraman, A., Fox, E. J., Golde, T. E., Johnson, E. C. B., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00757-1 · Cited by 38
Tandetnik, C., Hergueta, T., Bonnet, P., Dubois, B., & Bungener, C. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217001119 · Cited by 29
Self-citationFalcón, C., Tucholka, A., Monté, G. C., Cacciaglia, R., Operto, G., Rami, L., Gispert, J. D., & Molinuevo, J. L. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.04.016 · Cited by 29
Self-citationJoung, K.-I., Kim, S., Cho, Y. H., & Cho, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-43066-0 · Cited by 30
Chen, G., Yang, K. Y., Du, W., Hu, X., & Han, Y. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190501 · Cited by 30
Cell and Tissue Instructive Materials for Central Nervous System Repair
Rocha, L. A., Silva, D., Barata‐Antunes, S., Cavaleiro, H., Gomes, E. D., Silva, N. A., & Salgado, A. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909083 · Cited by 31
Samuelsson, J., Kern, S., Zetterberg, H., Blennow, K., Rothenberg, E. M., Wallengren, O., Skoog, I. G., & Zettergren, A. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12183 · Cited by 29
Self-citationAlzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Merighi, S., Poloni, T. E., Terrazzan, A., Moretti, E., Gessi, S., & Ferrari, D. (2021) · Cells · doi:10.3390/cells10051267 · Cited by 30
Elahi, F. M., Ashimatey, B. S., Bennett, D. J., Walters, S. M., Joie, R. L., Jiang, X., Wolf, A. A., Cobigo, Y., Staffaroni, A. M., Rosen, H. J., et al. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12181 · Cited by 29
Self-citationJeong, S. H., Kim, H. R., Kim, J., Kim, H., Hong, N., Jung, J. H., Baik, K., Cho, H., Lyoo, C. H., Ye, B. S., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012534 · Cited by 32
Parkinsonism and motor neuron disorders: Lessons from Western Pacific ALS/PDC
Spencer, P. S. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120021 · Cited by 29
Butler, L. M., Houghton, R., Abraham, A., Vassilaki, M. E., & Durán-Pacheco, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.749305 · Cited by 29
Alzheimer's disease amyloid-β pathology in the lens of the eye
Moncaster, J. A., Moir, R. D., Burton, M. A., Chadwick, O., Minaeva, O. V., Alvarez, V. E., Ericsson, M., Clark, J. I., McKee, A. C., Tanzi, R. E., et al. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.108974 · Cited by 30
Ferreira, P. C. L., Ferrari‐Souza, J. P., Tissot, C., Bellaver, B., Leffa, D. T., Lussier, F. Z., Povala, G., Therriault, J., Benedet, A. L., Ashton, N. J., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207115 · Cited by 28
Self-citationGiangrande, C., Delatour, V., Andréasson, U., Blennow, K., Gobom, J., & Zetterberg, H. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12465 · Cited by 31
Self-citationVenneri, A., Mitolo, M., Beltrachini, L., Varma, S., Pietà, C. D., Carta, C., Frangi, A. F., & Marco, M. D. (2019) · Neuropsychology · doi:10.1037/neu0000534 · Cited by 34
Lue, L., Kuo, Y., & Sabbagh, M. N. (2019) · Neurology and Therapy · doi:10.1007/s40120-019-00167-2 · Cited by 29
Mozzi, A., Guerini, F. R., Forni, D., Costa, A. S., Nemni, R., Baglio, F., Cabinio, M., Riva, S., Pontremoli, C., Clerici, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10245-w · Cited by 28
Tort‐Merino, A., Valech, N., Peñaloza, C., Grönholm-Nyman, P., León, M., Olives, J., Estanga, A., Ecay‐Torres, M., Fortea, J., Martínez‐Lage, P., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161173 · Cited by 33
Self-citationN-of-1 Clinical Trials in Nutritional Interventions Directed at Improving Cognitive Function
Soldevila‐Domenech, N., Boronat, A., Langohr, K., & de la Torre, R. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00110 · Cited by 27
Tabatabaei-Jafari, H., Shaw, M. E., Walsh, E., & Cherbuin, N. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.033 · Cited by 29
Shumbayawonda, E., López‐Sanz, D., Bruña, R., Serrano, N., Fernández, A., Maestú, F., & Abásolo, D. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.023 · Cited by 30
New markers in Parkinson's disease
Bougea, A. M. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.12.001 · Cited by 28
Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning
Castillo-Barnés, D., Su, L., Ramírez, J., Salas-Gonzalez, D., Martínez-Murcia, F. J., Illán, I. A., Segovia, F., Ortíz, A., Cruchaga, C., Farlow, M. R., et al. (2020) · Information Fusion · doi:10.1016/j.inffus.2020.01.001 · Cited by 29
Self-citationPrefrontal network dysfunctions in rapid eye movement sleep behavior disorder
Wakasugi, N., Togo, H., Mukai, Y., Nishikawa, N., Sakamoto, T., Murata, M., Takahashi, Y., Matsuda, H., & Hanakawa, T. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.03.005 · Cited by 30
Advances in Modeling Alzheimer's Disease In Vitro
Sharma, N. S., Karan, A., Lee, D.-H., Yan, Z., & Xie, J. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100097 · Cited by 31
Qiao, H., Chen, L., & Zhu, F. (2021) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2021.106503 · Cited by 29
Abazid, M., Houmani, N., Boudy, J., Dorizzi, B., Mariani, J., & Kinugawa, K. (2021) · Entropy · doi:10.3390/e23111553 · Cited by 28
Cope, T. E., Hughes, L. E., Phillips, H. N., Adams, N. E., Jafarian, A., Nesbitt, D., Assem, M., Woolgar, A., Duncan, J., & Rowe, J. B. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1622-21.2022 · Cited by 32
A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis
Needham, H., Torpey, G., Flores, C. C., Davis, C. J., Vanderheyden, W. M., & Gerstner, J. R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.798994 · Cited by 29
Spinelli, G., on behalf of the INSIGHT-preAD Study Group, Bakardjian, H., Schwartz, D., Potier, M., Habert, M., Lévy, M., Dubois, B., & George, N. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220204 · Cited by 32
Self-citationTarawneh, H. Y., Jayakody, D. M. P., Sohrabi, H. R., Martins, R. N., & Mulders, W. H. A. M. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220035 · Cited by 30
Cano, A. C., Antonio, E. E., Bernuz, M., Puerta, R., García‐González, P., de Rojas, I., Olivé, C., Pérez‐Cordón, A., Montrreal, L., Núñez‐Llaves, R., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01793-7 · Cited by 30
Skampardoni, I., Nasrallah, I. M., Abdulkadir, A., Wen, J., Melhem, R., Mamourian, E., Erus, G., Doshi, J., Singh, A., Yang, Z., et al. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.5599 · Cited by 28
Biomarker-based signature of alzheimer's disease in pre-MCI individuals
Chipi, E., Salvadori, N., Farotti, L., & Parnetti, L. (2019) · Brain Sciences · doi:10.3390/brainsci9090213 · Cited by 27
Zhukovsky, P., Coughlan, G., Buckley, R., Grady, C., & Voineskos, A. N. (2023) · Human Brain Mapping · doi:10.1002/hbm.26148 · Cited by 26
Cognitive medicine – a new approach in health care science.
Wallin, A., Kettunen, P., Johansson, P. M., Jonsdottir, I. H., Nilsson, C., Nilsson, M., Eckerström, M., Nordlund, A., Nyberg, L., Sunnerhagen, K. S., et al. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1615-0 · Cited by 27
Wyman‐Chick, K. A., Choudhury, P., Bayram, E., Ruiz, C. A., Matar, E., Chiu, S., Ferreira, D., Hamilton, C. A., Donaghy, P. C., Rodriguez‐Porcel, F. E., et al. (2024) · Neurology and Therapy · doi:10.1007/s40120-024-00620-x · Cited by 30
Metadata
- Authors
- Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., Broich, K., Cavedo, E., Crutch, S., Dartigues, J., Duyckaerts, C., Epelbaum, S., Frisoni, G. B., Gauthier, S., Genthon, R., Gouw, A. A., Habert, M., Holtzman, D. M., Kivipelto, M., Lista, S., Molinuevo, J., O'Bryant, S. E., Rabinovici, G. D., Rowe, C., Salloway, S., Schneider, L. S., Sperling, R., Teichmann, M., Carrillo, M. C., Cummings, J., Jack, C. R., & Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2. W. D.
- Affiliations
- Sorbonne Université (FR)
- University of British Columbia (CA)
- Amsterdam Neuroscience (NL)
- University of Southern California (US)
- Université Toulouse III - Paul Sabatier (FR)
- Institut du Cerveau (FR)
- Centre National de la Recherche Scientifique (FR)
- Institute for Integrative and Experimental Genomics (DE)
- Sahlgrenska University Hospital (SE)
- Federal Institute for Drugs and Medical Devices (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- UCL Queen Square Institute of Neurology (GB)
- Université de Bordeaux (FR)
- University of Geneva (CH)
- Douglas Mental Health University Institute (CA)
- Fondation pour la Recherche sur Alzheimer Hôpital Pitié‐Salpêtrière Paris France
- Washington University in St. Louis (US)
- Karolinska University Hospital (SE)
- AXA Research Fund (FR)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
- Center for Alzheimer's & Neurodegenerative Disease Research University of North Texas Health Science Center TX USA
- University of California, San Francisco (US)
- The University of Melbourne (AU)
- Brown University (US)
- Brigham and Women's Hospital (US)
- The Alzheimer's Association Division of Medical & Scientific Relations Chicago USA
- Cleveland Clinic (US)
- Department of Radiology Mayo Clinic Rochester MN USA
- Corresponding author
- Dubois, Bruno
- ORCID
- Dubois, Bruno
- Hampel, Harald
- Feldman, Howard H.
- Scheltens, Philip
- Andrieu, Sandrine
- Bakardjian, Hovagim
- Benali, Habib
- Bertram, Lars
- Blennow, Kaj
- Broich, Karl
- Cavedo, Enrica
- Crutch, Sebastian
- Dartigues, Jean‐François
- Duyckaerts, Charles
- Epelbaum, Stéphane
- Frisoni, Giovanni B.
- Gauthier, Serge
- Gouw, Alida A.
- Habert, Marie‐Odile
- Holtzman, David M.
- Kivipelto, Miia
- Lista, Simone
- Rabinovici, Gil D.
- Rowe, Christopher
- Salloway, Stephen
- Schneider, Lon S.
- Sperling, Reisa
- Teichmann, Marc
- Cummings, Jeffrey
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2016-03
- Volume
- 12
- Issue
- 3
- Pages
- 292-323
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6417794
- OpenAlex
- W2309442902
- Cited by
- 1,925
- References
- 298
- Citations by year
- 2026: 115 · 2025: 176 · 2024: 244 · 2023: 245 · 2022: 247 · 2021: 244 · 2020: 176 · 2019: 157 · 2018: 161 · 2017: 112 · 2016: 47
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- AXA Research Fund
- National Institute on Aging
- Alzheimer's Association
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- preclinical Alzheimer's disease, Alzheimer's disease continuum
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
