Cited by 147Nutritional Studies and DietDementia and Cognitive Impairment ResearchFatty Acid Research and Health

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Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

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Staubo, Sara C., Aakre, Jeremiah A., Vemuri, Prashanthi, Syrjanen, Jeremy A., Mielke, Michelle M., Geda, Yonas E., Kremers, Walter K., Machulda, Mary M., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Roberts, Rosebud O.·2017·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2016.06.2359PMC PMC5259552

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Abstract

INTRODUCTION: The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. METHODS: Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). RESULTS: Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. DISCUSSION: In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

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Authors: Staubo, S. C., Aakre, J. A., Vemuri, P., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., & Roberts, R. O.
Affiliations: Mayo Clinic (US)
Corresponding author: Roberts, Rosebud O.
ORCID: Aakre, Jeremiah A.
Vemuri, Prashanthi
Syrjanen, Jeremy A.
Mielke, Michelle M.
Geda, Yonas E.
Kremers, Walter K.
Machulda, Mary M.
Knopman, David S.
Petersen, Ronald C.
Jack, Clifford R.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2016-07-23
Volume: 13
Issue: 2
Pages: 168-177
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2016.06.2359
PMC: PMC5259552
OpenAlex: W2505127413
Cited by: 147
References: 49
Citations by year: 2026: 8 · 2025: 12 · 2024: 13 · 2023: 25 · 2022: 11 · 2021: 20 · 2020: 12 · 2019: 13 · 2018: 23 · 2017: 8 · 2016: 2
FWCI: 15.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (U01 AG006786, P50 AG016574, R01 AG011378, R01 AG041851)
U.S. Department of Defense
National Institute on Deafness and Other Communication Disorders
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: Mediterranean diet, cortical thickness
MeSH terms: Aged, Aged, 80 and over, Cerebral Cortex, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Organ Size, Micronutrients, Diet, Mediterranean

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Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

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