Cited by 1,162Nutritional Studies and DietDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

MIND diet associated with reduced incidence of Alzheimer's disease

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Morris, Martha Clare, Tangney, Christy C., Wang, Yamin, Sacks, Frank M., Bennett, David A., Aggarwal, Neelum T.·2015·Alzheimer's & Dementia

Abstract

Introduction: In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean‐Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD). Methods: We investigated the diet‐AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire. Results: In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates. Discussion: High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk.

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  • Emerging evidence suggests that consuming a heart-healthy diet may be associated with reduced dementia risk.

    “In addition to physical activity, emerging evidence suggests that consuming a heart-healthy diet may be associated with reduced dementia risk.129-134”

    From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [132]

  • Eating a heart-healthy diet and increasing physical activity could delay the onset of AD.

    “Collectively, this suggests that eating a heart-healthy diet [172,173,174,175,176] and increasing physical activity [177,178,179,180] could delay the onset of AD.”

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Authors
Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Bennett, D. A., & Aggarwal, N. T.
Affiliations
  • Rush University Medical Center (US)
  • Harvard University (US)
Corresponding author
Morris, Martha Clare
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2015-02-11
Volume
11
Issue
9
Pages
1007-1014
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W1990713904
Cited by
1,162
References
35
Citations by year
2026: 131 · 2025: 166 · 2024: 136 · 2023: 124 · 2022: 124 · 2021: 133 · 2020: 147 · 2019: 68 · 2018: 64 · 2017: 39 · 2016: 24 · 2015: 5
FWCI
47.19
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
National Institute on Aging (R01AG031553, R01AG17917)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
MIND diet, Alzheimer's disease
MeSH terms
Aged, 80 and over, Alzheimer Disease, Chicago, Cognition Disorders, Female, Humans, Male, Patient Compliance, Prospective Studies, Incidence, Proportional Hazards Models, Survival Analysis, Disease Progression, Diet, Mediterranean

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