The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Blood‐brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study
Open accessAbstract
Introduction: Small vessel disease (SVD) is a common contributor to dementia. Subtle blood‐brain barrier (BBB) leakage may be important in SVD‐induced brain damage. Methods: We assessed imaging, clinical variables, and cognition in patients with mild (i.e., nondisabling) ischemic lacunar or cortical stroke. We analyzed BBB leakage, interstitial fluid, and white matter integrity using multimodal tissue‐specific spatial analysis around white matter hyperintensities (WMH). We assessed predictors of 1 year cognition, recurrent stroke, and dependency. Results: In 201 patients, median age 67 (range 34–97), BBB leakage, and interstitial fluid were higher in WMH than normal‐appearing white matter; leakage in normal‐appearing white matter increased with proximity to WMH (P < .0001), with WMH severity (P = .033), age (P = .03), and hypertension (P < .0001). BBB leakage in WMH predicted declining cognition at 1 year. Discussion: BBB leakage increases in normal‐appearing white matter with WMH and predicts worsening cognition. Interventions to reduce BBB leakage may prevent SVD‐associated dementia.
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InfluentialWardlaw, J. M., Smith, E. E., Biessels, G. J., Cordonnier, C., Fazekas, F., Frayne, R., Lindley, R. I., O'Brien, J. T., Barkhof, F., Benavente, O. R., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70124-8 · Cited by 5,544
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The Pathobiology of Vascular Dementia
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Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0312-z · Cited by 870
Self-citationVascular dysfunction—The disregarded partner of Alzheimer's disease
Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.222 · Cited by 711
Self-citationBlood–brain barrier leakage is increased in parkinson’s disease
Al-Bachari, S., Naish, J. H., Parker, G. J. M., Emsley, H. C. A., & Parkes, L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.593026 · Cited by 263
Thrippleton, M. J., Backes, W. H., Sourbron, S., Ingrisch, M., van Osch, M. J. P., Dichgans, M., Fazekas, F., Ropele, S., Frayne, R., van Oostenbrugge, R. J., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.013 · Cited by 252
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Metadata
- Authors
- Wardlaw, J. M., Makin, S. J., Valdés Hernández, M. C., Armitage, P. A., Heye, A. K., Chappell, F. M., Muñoz‐Maniega, S., Sakka, E., Shuler, K., Dennis, M. S., & Thrippleton, M. J.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2016-10-27
- Volume
- 13
- Issue
- 6
- Pages
- 634-643
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2544891436
- Cited by
- 260
- References
- 24
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wardlaw, J. M., Makin, S. J., Valdés Hernández, M. C., Armitage, P. A., Heye, A. K., Chappell, F. M., Muñoz‐Maniega, S., Sakka, E., Shuler, K., Dennis, M. S., & Thrippleton, M. J. (2017). Blood‐brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Alzheimer's & Dementia. https://doi.org/10.1016/j.jalz.2016.09.006
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