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Cited by 176Dementia and Cognitive Impairment ResearchBlood Pressure and Hypertension StudiesNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study

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Corrada, María M., Hayden, Kathleen M., Paganini-Hill, Annlia, Bullain, Szofia S., DeMoss, Jaime, Aguirre, Colette, Brookmeyer, Ron, Kawas, Claudia H.·2017·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2016.09.007PMC PMC5318224
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Abstract

Introduction: We investigated the association between age of onset of hypertension and dementia risk in an oldest‐old cohort. Methods: Participants are from The 90+ Study, a population‐based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self‐reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years. Results: A total of 224 participants developed dementia during follow‐up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004). Discussion: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.

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Metadata

Authors
Corrada, M. M., Hayden, K. M., Paganini-Hill, A., Bullain, S. S., DeMoss, J., Aguirre, C., Brookmeyer, R., & Kawas, C. H.
Affiliations
  • University of California, Irvine (US)
  • Wake Forest University Health Sciences (US)
  • Department of Neurology University of California Irvine Irvine CA USA
  • University of California, Los Angeles (US)
Corresponding author
Corrada, María M.
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2017-01-16
Volume
13
Issue
2
Pages
103-110
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2016.09.007
PMC
PMC5318224
OpenAlex
W2115381884
Cited by
176
References
44
Citations by year
2026: 8 · 2025: 16 · 2024: 12 · 2023: 17 · 2022: 22 · 2021: 24 · 2020: 20 · 2019: 27 · 2018: 17 · 2017: 7
FWCI
15.94
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institutes of Health (R01AG21055, R01AG042444, R01CA32197)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
hypertension, age of onset
MeSH terms
Mental Status and Dementia Tests, Aged, 80 and over, Antihypertensive Agents, Dementia, Female, Follow-Up Studies, Humans, Hypertension, Longitudinal Studies, Male, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Proportional Hazards Models, Age of Onset, Self Report

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