Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers
Open accessAbstract
The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age-related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein- and gene-centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application.
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Dietary intervention represents a fairly straightforward manner to achieve proper lipid homeostasis.
“Lipids provide a further advantage in that dietary intervention represents a fairly straightforward manner to achieve proper lipid homeostasis [111,112,113].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [113]
Dysregulation of lipids has been linked to neurodegenerative disorders, including AD.
“their dysregulation has been linked to neurodegenerative disorders, including AD24”
From Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease (2025) · cites this paper as [24]
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1 retracted
Rao, J. S., Rapoport, S. I., & Kim, H. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.27 · Cited by 86 · see citing works
RetractedA SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143 · see citing works
Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
Matyash, V., Liebisch, G., Kurzchalia, T. V., Shevchenko, A., & Schwudke, D. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d700041-jlr200 · Cited by 2,615 · see citing works
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,238 · see citing works
Update of the LIPID MAPS comprehensive classification system for lipids
Fahy, E., Subramaniam, S., Murphy, R. C., Nishijima, M., Raetz, C. R. H., Shimizu, T., Spener, F., Gerrit van, M. E. E. R., Wakelam, M. J. O., & Dennis, E. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800095-jlr200 · Cited by 1,766 · see citing works
Ion Suppression in Mass Spectrometry
Annesley, T. M. (2003) · Clinical Chemistry · doi:10.1373/49.7.1041 · Cited by 1,598 · see citing works
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works
Han, X., & Gross, R. W. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20023 · Cited by 1,111 · see citing works
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works
Plasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,031 · see citing works
Lipidomics: coming to grips with lipid diversity
Shevchenko, A., & Simons, K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2934 · Cited by 828 · see citing works
Kivipelto, M., Helkala, E., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Iivonen, S., Mannermaa, A., Tuomilehto, J., Nissinen, A. M., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-3-200208060-00006 · Cited by 645 · see citing works
Han, X., Holtzman, D. M., & McKeel, D. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00332.x · Cited by 562 · see citing works
Identification of type 2 diabetes subgroups through topological analysis of patient similarity
Li, L., Cheng, W., Glicksberg, B. S., Gottesman, O., Tamler, R., Chen, R., Böttinger, E. P., & Dudley, J. T. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa9364 · Cited by 548 · see citing works
Deregulation of sphingolipid metabolism in Alzheimer’s disease
He, X., Huang, Y., Li, B., Gong, C.-X., & Schuchman, E. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.010 · Cited by 516 · see citing works
Differences between Human Plasma and Serum Metabolite Profiles
Yu, Z., Kastenmüller, G., He, Y., Belcredi, P., Möller, G., Prehn, C. P., Mendes, J., Wahl, S., Roemisch‐Margl, W., Ceglarek, U., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021230 · Cited by 496 · see citing works
Trushina, E., Dutta, T., Persson, X.-M. T., Mielke, M. M., & Petersen, R. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063644 · Cited by 438 · see citing works
Han, X., Rozen, S., Boyle, S. H., Hellegers, C., Cheng, H., Burke, J. R., Welsh-Bohmer, K. A., Doraiswamy, P. M., & Kaddurah-Daouk, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021643 · Cited by 429 · see citing works
Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges
Füzéry, A. K., Levin, J. D., Chan, M. M., & Chan, D. W. (2013) · Clinical Proteomics · doi:10.1186/1559-0275-10-13 · Cited by 428 · see citing works
Dieterle, F., Sistare, F. D., Goodsaid, F. M., Papaluca, M., Ozer, J. S., Webb, C. P., Baer, W., Senagore, A. J., Schipper, M. J., Vonderscher, J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1625 · Cited by 410 · see citing works
Drucker, E., & Krapfenbauer, K. (2013) · The EPMA Journal · doi:10.1186/1878-5085-4-7 · Cited by 352 · see citing works
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
Whiley, L., Sen, A., Heaton, J. C., Proitsi, P., García‐Gómez, D., Leung, R., Smith, N. W., Thambisetty, M., Kłoszewska, I., Mecocci, P., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.001 · Cited by 342 · see citing works
Self-citationPonnusamy, S., Meyers‐Needham, M., Senkal, C. E., Saddoughi, S. A., Sentelle, D., Selvam, S. P., Salas, A., & Öğretmen, B. (2010) · Future Oncology · doi:10.2217/fon.10.116 · Cited by 313 · see citing works
Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial
Scheltens, P., Twisk, J. W. R., Blesa, R., Scarpini, E. A., Arnim, C. A. F. V., Bongers, A., Harrison, J., Willemsen‐Swinkels, S. H. N., Stam, C. J., de Waal, H., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121189 · Cited by 306 · see citing works
O’Bryant, S. E., Gupta, V. B., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C. E., Soares, H. D., Lovestone, S., Hampel, H. J., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.08.099 · Cited by 290 · see citing works
Surma, M. A., Herzog, R., Vasilj, A., Klose, C. D., Christinat, N., Morin‐Rivron, D., Simons, K., Masoodi, M., & Sampaio, J. L. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201500145 · Cited by 285 · see citing works
Xiong, H., Callaghan, D., Jones, A., Walker, D. G., Lue, L., Beach, T. G., Sue, L. I., Woulfe, J., Xu, H., Stanimirovic, D. B., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.005 · Cited by 283 · see citing works
SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function
Dart, C. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.191585 · Cited by 268 · see citing works
Barri, T., & Dragsted, L. O. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.01.015 · Cited by 268 · see citing works
Brügger, B. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035324 · Cited by 265 · see citing works
A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL
Reis, A., Rudnitskaya, A. M., Blackburn, G. J., Fauzi, N. M., Pitt, A. R., & Spickett, C. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034330 · Cited by 242 · see citing works
Targeted Metabolomics Identifies Reliable and Stable Metabolites in Human Serum and Plasma Samples
Breier, M., Wahl, S., Prehn, C. P., Fugmann, M., Ferrari, U., Weise, M., Banning, F., Seißler, J., Grallert, H., Adamski, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089728 · Cited by 240 · see citing works
Serum ceramides increase the risk of Alzheimer disease
Mielke, M. M., Bandaru, V. V. R., Haughey, N. J., Xia, J., Fried, L. P., Yaşar, S., Albert, M., Varma, V. R., Harris, G., Schneider, E. B., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318264e380 · Cited by 223 · see citing works
An Efficient Single Phase Method for the Extraction of Plasma Lipids
Alshehry, Z. H., Barlow, C. K., Weir, J. M., Zhou, Y., McConville, M. J., & Meikle, P. J. (2015) · Metabolites · doi:10.3390/metabo5020389 · Cited by 219 · see citing works
Claxton, A., Baker, L. D., Wilkinson, C. W., Trittschuh, E. H., Chapman, D., Watson, G. S., Cholerton, B., Plymate, S. R., Arbuckle, M., & Craft, S. (2013) · Journal of Alzheimer’s Disease · doi:10.3233/jad-122308 · Cited by 215 · see citing works
Song, F., Poljak, A., Crawford, J., Kochan, N. A., Wen, W., Cameron, B., Lux, O., Brodaty, H., Mather, K., Smythe, G. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034078 · Cited by 214 · see citing works
Self-citationPhospholipids and Alzheimer’s Disease: Alterations, Mechanisms and Potential Biomarkers
Košiček, M., & Hecimovic, S. K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011310 · Cited by 213 · see citing works
Hong, S., Ostaszewski, B. L., Yang, T., O’Malley, T. T., Jin, M., Yanagisawa, K., Li, S., Bartels, T., & Selkoe, D. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.027 · Cited by 213 · see citing works
Dhingra, R., & Vasan, R. S. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.07.005 · Cited by 212 · see citing works
Mullen, T. D., & Obeid, L. M. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012800228661 · Cited by 204 · see citing works
Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
Proitsi, P., Kim, M. G., Whiley, L., Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M. K., Soininen, H., Kłoszewska, I., Mecocci, P., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.08.003 · Cited by 203 · see citing works
APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms
Conejero-Goldberg, C., Gomar, J. J., Bobes-Bascaran, T., Hyde, T. M., Kleinman, J. E., Herman, M. M., Chen, S., Davies, P., & Goldberg, T. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.194 · Cited by 199 · see citing works
Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis
Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.056 · Cited by 195 · see citing works
Marquer, C., Devauges, V., Cossec, J., Liot, G., Lécart, S., Saudou, F., Duyckaerts, C. J., Lévêque‐Fort, S., & Potier, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-168633 · Cited by 188 · see citing works
Ishikawa, M., Maekawa, K., Saito, K., Senoo, Y., Urata, M., Murayama, M., Tajima, Y., Kumagai, Y., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091806 · Cited by 187 · see citing works
Meikle, P. J., Wong, G., Barlow, C. K., & Kingwell, B. A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.001 · Cited by 185 · see citing works
Mass Spectrometry Based Lipidomics: An Overview of Technological Platforms
Köfeler, H. C., Fauland, A., Rechberger, G. N., & Trötzmüller, M. (2012) · Metabolites · doi:10.3390/metabo2010019 · Cited by 181 · see citing works
Mulder, C., Wahlund, L., Teerlink, T., Blomberg, M. I., Veerhuis, R., van Kamp, G. J., Scheltens, P., & Scheffer, P. G. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0007-9 · Cited by 174 · see citing works
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
Song, F., Poljak, A., Smythe, G. A., & Sachdev, P. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.003 · Cited by 173 · see citing works
Self-citationMielke, M. M., Haughey, N. J., Bandaru, V. V. R., Schech, S., Carrick, R., Carlson, M. C., Mori, S., Miller, M. I., Ceritoglu, C., Brown, T., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.014 · Cited by 170 · see citing works
Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients
Walter, A., Korth, U., Hilgert, M., Hartmann, J., Weichel, O., Hilgert, M., Fassbender, K. C., Schmitt, A., & Klein, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.016 · Cited by 165 · see citing works
Fabelo, N., Martín, M. V., Marín, R., Moreno, D., Ferrer, I., & Díaz, M. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.005 · Cited by 164 · see citing works
Casanova, R., Varma, S., Simpson, B. N., Kim, M. G., An, Y., Saldana, S. J., Riveros, C., Moscato, P., Griswold, M. E., Sonntag, D., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.12.008 · Cited by 162 · see citing works
Self-citationAlshaarawy, O., Elbaz, H. A., & Andrew, M. E. (2016) · Environment International · doi:10.1016/j.envint.2016.02.006 · Cited by 162 · see citing works
Loss of the neuroprotective factor sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
Couttas, T. A., Kain, N., Daniels, B., Lim, X. Y., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., & Don, A. S. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-9 · Cited by 161 · see citing works
Self-citationPlasma Sphingomyelins are Associated with Cognitive Progression in Alzheimer's Disease
Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Weinberg, D. D., Darby, E. J., Zaidi, N., Pavlik, V., Doody, R. S., & Lyketsos, C. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110405 · Cited by 158 · see citing works
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.
Bandaru, V. R., Troncoso, J., Wheeler, D., Pletnikova, O., Wang, J., Conant, K., & Haughey, N. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.024 · Cited by 157 · see citing works
Serum total cholesterol, statins and cognition in non-demented elderly
Solomon, A., Kåreholt, I., Ngandu, T., Wolozin, B., MacDonald, S. W. S., Winblad, B., Nissinen, A., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.012 · Cited by 149 · see citing works
Zuo, H., Ueland, P., Ulvik, A., Eussen, S., Vollset, S., Nygård, O., Midttun, Ø., Theofylaktopoulou, D., Meyer, K., & Tell, G. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv242 · Cited by 149 · see citing works
Lipid changes in the aged brain: Effect on synaptic function and neuronal survival
Ledesma, M. D., Martín, M. G., & Dotti, C. G. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.004 · Cited by 148 · see citing works
Involvement of Sphingosine-1-Phosphate in Glutamate Secretion in Hippocampal Neurons
Kajimoto, T., Okada, T., Yu, H., Goparaju, S. K., Jahangeer, S. M., & Nakamura, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01465-06 · Cited by 146 · see citing works
González‐Domínguez, R., García‐Barrera, T., & Gómez‐Ariza, J. L. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.01.014 · Cited by 144 · see citing works
Lazar, A. N., Bich, C., Panchal, M., Desbenoît, N., Petit, V. W., Touboul, D., Dauphinot, L., Marquer, C., Laprévôte, O., Brunelle, A., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1041-1 · Cited by 141 · see citing works
Muhlestein, J. B., May, H. T., Jensen, J. R., Horne, B. D., Lanman, R. B., Lavasani, F., Wolfert, R. L., Pearson, R. R., Yannicelli, H. D., & Anderson, J. L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.009 · Cited by 140 · see citing works
Karsdal, M. A., Henriksen, K., Leeming, D. J., Mitchell, P. G., Duffin, K. L., Barascuk, N., Klickstein, L. B., Aggarwal, P., Nemirovskiy, O. V., Byrjalsen, I., et al. (2009) · Biomarkers · doi:10.1080/13547500902777608 · Cited by 135 · see citing works
de Waal, H., Stam, C. J., Lansbergen, M. M., Wieggers, R. L., Kamphuis, P. J. G. H., Scheltens, P., Maestú, F., & van Straaten, E. C. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086558 · Cited by 119 · see citing works
Shah, R. C., Kamphuis, P. J., Leurgans, S., Swinkels, S. H., Sadowsky, C. H., Bongers, A., Rappaport, S. A., Quinn, J. F., Wieggers, R. L., Scheltens, P., et al. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt224 · Cited by 112 · see citing works
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia
Han, X., Fagan, A. M., Cheng, H., Morris, J. C., Xiong, C., & Holtzman, D. M. (2003) · Annals of Neurology · doi:10.1002/ana.10618 · Cited by 111 · see citing works
Klavins, K., Koal, T., Dallmann, G., Marksteiner, J., Kemmler, G., & Humpel, C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.05.003 · Cited by 110 · see citing works
Panchal, M., Loeper, J., Cossec, J., Perruchini, C., Lazar, A., Pompon, D., & Duyckaerts, C. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m001859 · Cited by 106 · see citing works
Greving, J. P., Buskens, E., Koffijberg, H., & Algra, A. (2008) · Circulation · doi:10.1161/circulationaha.107.735340 · Cited by 103 · see citing works
Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease
Košiček, M., Zetterberg, H., Andreasen, N., Peter‐Katalinić, J., & Hecimovic, S. K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.019 · Cited by 102 · see citing works
Biomarker Discovery and Translation in Metabolomics
Gowda, G. N., & Raftery, D. (2013) · Current Metabolomics · doi:10.2174/2213235x113019990005 · Cited by 102 · see citing works
Choi, S., Chae, A., Miller, E. R., Messig, M., Ntanios, F. Y., DeMaria, A. N., Nissen, S. E., Witztum, J. L., & Tsimikas, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.066 · Cited by 98 · see citing works
GM1 ganglioside and Alzheimer’s disease
Yanagisawa, K. (2015) · Glycoconjugate Journal · doi:10.1007/s10719-015-9579-5 · Cited by 93 · see citing works
Optimizing the lipidomics workflow for clinical studies—practical considerations
Hyötyläinen, T., & Orešič, M. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8633-2 · Cited by 92 · see citing works
Bennett, S. A. L., Valenzuela, N., Xu, H., Franko, B., Fai, S., & Figeys, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00168 · Cited by 86 · see citing works
Mielke, M. M., Bandaru, V. V. R., Han, D., An, Y., Resnick, S. M., Ferrucci, L., & Haughey, N. J. (2015) · Aging Cell · doi:10.1111/acel.12369 · Cited by 85 · see citing works
Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons
Schneider, A., Schulz‐Schaeffer, W., Hartmann, T., Schulz, J. B., & Simons, M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.015 · Cited by 84 · see citing works
Comparison of blood plasma sample preparation methods for combined LC–MS lipidomics and metabolomics
Patterson, R. E., Ducrocq, A. J., McDougall, D. J., Garrett, T. J., & Yost, R. A. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.08.018 · Cited by 80 · see citing works
Mielke, M. M., Bandaru, V. V. R., Han, D., An, Y., Resnick, S. M., Ferrucci, L., & Haughey, N. J. (2014) · Aging Cell · doi:10.1111/acel.12275 · Cited by 79 · see citing works
Loprinzi, P. D., Branscum, A. J., Hanks, J. E., & Smit, E. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.01.009 · Cited by 76 · see citing works
Li, D., Misialek, J. R., Boerwinkle, E., Gottesman, R. F., Sharrett, A. R., Mosley, T. H., Coresh, J., Wruck, L. M., Knopman, D. S., & Alonso, Á. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.02.008 · Cited by 71 · see citing works
Yang, W. Q., Chen, Y., Xi, C., Zhang, R., Song, Y., Zhan, Q., Bi, X., & Abliz, Z. (2013) · Analytical Chemistry · doi:10.1021/ac303576b · Cited by 67 · see citing works
Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease
Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Zetterberg, H., Blennow, K., Andréasson, U., Johnson, S. C., Gleason, C. E., Blazel, H. M., Puglielli, L., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.019 · Cited by 66 · see citing works
Blood metabolite markers of cognitive performance and brain function in aging
Simpson, B. N., Kim, M. G., Chuang, Y., Beason‐Held, L. L., Kitner‐Triolo, M. H., Kraut, M. A., Lirette, S. T., Windham, B. G., Griswold, M. E., Legido‐Quigley, C., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15611678 · Cited by 65 · see citing works
Self-citationLipid and inflammatory biomarkers and kidney function decline in type 2 diabetes
Lin, J., Hu, F. B., Mantzoros, C. S., & Curhan, G. C. (2009) · Diabetologia · doi:10.1007/s00125-009-1597-z · Cited by 61 · see citing works
Song, J., Liu, X., Wu, J., Meehan, M. J., Blevitt, J. M., Dorrestein, P. C., & Milla, M. E. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.10.022 · Cited by 61 · see citing works
Wood, P. L., Locke, V. A., Herling, P., Passaro, A., Vigna, G. B., Volpato, S., Valacchi, G., Cervellati, C., & Zuliani, G. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.11.004 · Cited by 60 · see citing works
Yanagisawa, K. (2005) · The Neuroscientist · doi:10.1177/1073858405275177 · Cited by 55 · see citing works
Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study
Chatterjee, P., Lim, W. L. F., Shui, G., Gupta, V. B., JAMES, I. R., Fagan, A. M., Xiong, C., Sohrabi, H. R., Taddei, K., Brown, B. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150948 · Cited by 52 · see citing works
Discovering and validating between-subject variations in plasma lipids in healthy subjects
Begum, H., Li, B., Shui, G., Cazenave‐Gassiot, A., Soong, R. C. T., Ong, R. T., Little, P., Teo, Y., & Wenk, M. R. (2016) · Scientific Reports · doi:10.1038/srep19139 · Cited by 50 · see citing works
Motoki, K., Kume, H., Oda, A., Tamaoka, A., Hosaka, A., Kametani, F., & Araki, W. (2012) · Brain and Behavior · doi:10.1002/brb3.52 · Cited by 45 · see citing works
Schalken, J. A. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.025 · Cited by 45 · see citing works
Harmon, M. E., Campen, M. J., Miller, C. P., Shuey, C., Cajero, M., Lucas, S., Pacheco, B., Erdei, E., Ramone, S., Nez, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0143102 · Cited by 45 · see citing works
Miyamoto, K., Takeuchi, D., Inai, K., Shinohara, T., & Nakanishi, T. (2016) · Heart and Vessels · doi:10.1007/s00380-016-0807-0 · Cited by 44 · see citing works
Ariga, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9641-0 · Cited by 43 · see citing works
Li, J., Hu, C., Zhao, X., Dai, W., Chen, S., Lu, X., & Xu, G. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.10.064 · Cited by 41 · see citing works
The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease
Hanson, A. J., Craft, S., & Banks, W. A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141020164222 · Cited by 41 · see citing works
Prediction of Cardiovascular Disease Risk by Cardiac Biomarkers in 2 United Kingdom Cohort Studies
Welsh, P. I., Hart, C., Papacosta, O., Preiss, D., McConnachie, A., Murray, H. M., Ramsay, S. E., Upton, M. N., Watt, G. C. M., Whincup, P. H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06501 · Cited by 40 · see citing works
Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model
Cho, S. M., Kim, H. V., Lee, S., Kim, H. Y., Kim, W., Kim, T. S., Kim, D. J., & Kim, Y. S. (2014) · Scientific Reports · doi:10.1038/srep06777 · Cited by 37 · see citing works
A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer's Disease
Hartmann, T., van Wijk, N., Wurtman, R. J., Rikkert, M. G. M. O., Sijben, J., Soininen, H. S., Vellas, B. J., & Scheltens, P. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141137 · Cited by 35 · see citing works
Jørgenrud, B., Jäntti, S. E., Mattila, I. M., Pöhö, P., Rnningen, K. S., Yki‐Järvinen, H., Orešič, M., & Hyötyläinen, T. (2015) · Bioanalysis · doi:10.4155/bio.15.16 · Cited by 35 · see citing works
Góth, L., Nagy, T., Kósa, Z., Fejes, Z., Bhattoa, H. P., Paragh, G., & Káplár, M. (2012) · Free Radical Research · doi:10.3109/10715762.2012.702899 · Cited by 34 · see citing works
Onakpoya, I., & Heneghan, C. J. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1110899 · Cited by 32 · see citing works
Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles
Chan, M. K., Cooper, J. D., & Bahn, S. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.09.010 · Cited by 26 · see citing works
Agarwala, A., Virani, S. S., Couper, D. J., Chambless, L. E., Boerwinkle, E., Astor, B. C., Hoogeveen, R. C., Coresh, J., Sharrett, A. R., Folsom, A. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.028 · Cited by 21 · see citing works
Zhao, L., Jin, W., Rader, D. J., Packard, C. J., & Feuerstein, G. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.014 · Cited by 17 · see citing works
Sapsford, K. E., Težak, Ž., Kondratovich, M., Pacanowski, M. A., Zineh, I., & Mansfield, E. A. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.62 · Cited by 16 · see citing works
Pharmacogenomic Biomarker Information in FDA ‐approved Paediatric Drug Labels
Kim, T., Han, N., Sohn, M., Oh, J. M., Lee, E., Ji, E., & Kim, I. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12341 · Cited by 10 · see citing works
Justifying reimbursement for Alzheimer's diagnostics and treatments: Seeking alignment on evidence
Foster, N. L., Hackett, J., White, G., Chenevert, S., Svarvar, P., Bain, L. J., & Carrillo, M. C. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.003 · Cited by 9 · see citing works
Cseprekál, O., Egresits, J., Tabák, Á. G., Nemcsik, J., Járai, Z., Babos, L., Fodor, E., Farkas, K., Godina, G., Kárpáthi, K. I., et al. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.96 · Cited by 8 · see citing works
Integrating Biomarkers and Imaging for Cardiovascular Disease Risk Assessment in Diabetes
Tehrani, D. M., & Wong, N. D. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0789-7 · Cited by 7 · see citing works
Kin, N. M. K. N. Y., Pan, L. H., Louvaris, J. H., Robitaille, Y., & Nair, N. P. V. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1857-0_8 · Cited by 4 · see citing works
Freidlin, B., & Korn, E. L. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv430 · Cited by 3 · see citing works
FDA and CLIA Oversight of Advanced Diagnostics and Biomarker Tests
Terry, S. F. (2010) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2010.1510 · Cited by 2 · see citing works
[Companion diagnostics and reimbursement system].
Tazawa, Y. (2013) · PubMed · Cited by 1 · see citing works
Laughman, K. (2014) · PubMed · Cited by 1 · see citing works
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Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138 · see citing works
Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works
Brain age and other bodily ‘ages’: implications for neuropsychiatry
Cole, J. H., Marioni, R. E., Harris, S. E., & Deary, I. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0098-1 · Cited by 436 · see citing works
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353 · see citing works
Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324 · see citing works
Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 306 · see citing works
Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome
Fitzner, D., Bader, J. M., Penkert, H., Bergner, C. G., Su, M., Weil, M., Surma, M. A., Mann, M., Klose, C. D., & Simons, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108132 · Cited by 280 · see citing works
Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease
Whelan, C. D., Mattsson, N., Nagle, M. W., Vijayaraghavan, S., Hyde, C., Janelidze, S., Stomrud, E., Lee, J., Fitz, L., Samad, T. A., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0795-2 · Cited by 262 · see citing works
Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease
Su, H., Rustam, Y. H., Masters, C. L., Makalic, E., McLean, C., Hill, A. F., Barnham, K. J., Reid, G. E., & Vella, L. J. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12089 · Cited by 187 · see citing works
Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171 · see citing works
Mesa-Herrera, F., Taoro‐González, L., Valdés‐Baizabal, C., Díaz, M. L., & Marín, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153810 · Cited by 182 · see citing works
Li, Y., Cheng, Y., Zhou, Y., Du, H., Zhang, C., Zhao, Z., Chen, Y., Zhou, Z., Mei, J., Wu, W., et al. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113949 · Cited by 150 · see citing works
McCartney, D. L., Stevenson, A. J., Walker, R. M., Gibson, J., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., McIntosh, A. M., et al. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.05.006 · Cited by 134 · see citing works
Cerebral consequences of environmental noise exposure
Hahad, O., Jiménez, M. T. B., Kuntić, M., Frenis, K., Steven, S., Daiber, A., & Münzel, T. F. (2022) · Environment International · doi:10.1016/j.envint.2022.107306 · Cited by 137 · see citing works
Akyol, S., Ugur, Z., Yılmaz, A., Ustun, I., Gorti, S. K. K., Oh, K., McGuinness, B., Passmore, P., Kehoe, P. G., Maddens, M. E., et al. (2021) · Cells · doi:10.3390/cells10102591 · Cited by 132 · see citing works
Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review
Sun, T., Wang, X., Cong, P., Xu, J., & Xue, C. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12603 · Cited by 127 · see citing works
Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works
“Lipid accumulation in AD has been under-studied relative to other pathologies, but alterations in lipid metabolism and homeostasis are now emerging as a hallmark of AD brains (Liu and Zhang, 2014; Farmer et al., 2019; Wong et al., 2017).”
BackgroundCano, A., Turowski, P., Ettcheto, M., Duskey, J. T., Tosi, G., Sánchez-López, E., García, M. L., Camins, A., Souto, E. B., Ruiz, A., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00864-x · Cited by 122 · see citing works
Clark, C., Dayon, L., Masoodi, M., Bowman, G. L., & Popp, J. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00814-7 · Cited by 116 · see citing works
Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110 · see citing works
Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.029 · Cited by 104 · see citing works
Lipids as biomarkers of brain disorders
Hussain, G., Anwar, H., Rasul, A., Imran, A., Qasim, M., Zafar, S., Imran, M., Kamran, S., Aziz, N., Razzaq, A., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1529653 · Cited by 105 · see citing works
Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis
Weidling, I. W., & Swerdlow, R. H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113321 · Cited by 100 · see citing works
Exploring the Lipidome: Current Lipid Extraction Techniques for Mass Spectrometry Analysis
Aldana, J., Romero-Otero, A., & Cala, M. P. (2020) · Metabolites · doi:10.3390/metabo10060231 · Cited by 100 · see citing works
López‐Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., Garcı́a, Ó., Toschi, N., Giuliano, F. D., Garaci, F. G., Mercuri, N. B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062897 · Cited by 101 · see citing works
Kim, O. Y., & Song, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122356 · Cited by 96 · see citing works
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease
Park, S. A., Han, S. M., & Kim, C. E. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0418-9 · Cited by 91 · see citing works
Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review
Agarwal, M., & Khan, S. (2020) · Cureus · doi:10.7759/cureus.12008 · Cited by 85 · see citing works
Age and sex are associated with the plasma lipidome: findings from the GOLDN study
Slade, E., Irvin, M. R., Xie, K., Arnett, D. K., Claas, S. A., Kind, T., Fardo, D. W., & Graf, G. A. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01456-2 · Cited by 83 · see citing works
Fracassi, A., Marcatti, M., Zolochevska, O., Tabor, N., Woltjer, R., Moreno, S., & Taglialatela, G. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0295-20.2020 · Cited by 81 · see citing works
Jo, T., Nho, K., Bice, P., Saykin, A. J., & Initiative, F. T. A. D. N. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac022 · Cited by 80 · see citing works
Wong, M. W. K., Braidy, N., Pickford, R., Sachdev, P. S., & Poljak, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00879 · Cited by 75 · see citing works
Self-citationMartemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 81 · see citing works
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
Barupal, D. K., Baillie, R., Fan, S., Saykin, A. J., Meikle, P. J., Arnold, M., Nho, K. T., Fiehn, O., Kaddurah-Daouk, R. F., & Initiative, A. D. N. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.07.002 · Cited by 74 · see citing works
Integrative metabolomics science in Alzheimer’s disease: Relevance and future perspectives
Lista, S., González‐Domínguez, R., López‐Ortiz, S., González‐Domínguez, Á., Menéndez, H., Martín-Hernández, J., Lucía, A., Emanuele, E., Centonze, D., Imbimbo, B. P., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101987 · Cited by 75 · see citing works
Dorninger, F., Moser, A. B., Kou, J., Wiesinger, C., Forss-Petter, S., Gleiss, A., Hinterberger, M., Jungwirth, S., Fischer, P., & Berger, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171036 · Cited by 70 · see citing works
Castellanos, D. B., Martín-Jiménez, C., Rojas-Rodríguez, F., Barreto, G., & Santos, J. G. (2021) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2021.100899 · Cited by 58 · see citing works
Curcumin Alleviates DSS‐Induced Anxiety‐Like Behaviors via the Microbial‐Brain‐Gut Axis
Zhang, F., Zhou, Y., Chen, H., Jiang, H., Zhou, F., Lü, B., & Xu, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6244757 · Cited by 69 · see citing works
Barupal, D. K., Fan, S., Wancewicz, B., Cajka, T., Sa, M., Showalter, M. R., Baillie, R., Tenenbaum, J. D., Louie, G., Initiative, A. D. N., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.263 · Cited by 65 · see citing works
Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study
Fernández‐Irigoyen, J., Cartas‐Cejudo, P., Iruarrizaga‐Lejarreta, M., & Santamaría, E. (2021) · Biomedicines · doi:10.3390/biomedicines9050491 · Cited by 66 · see citing works
Cao, Y., Zhao, L., Chen, Z., & Li, S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1430465 · Cited by 58 · see citing works
Platelet biomarkers for a descending cognitive function: A proteomic approach
Yu, H., Liu, Y., He, B., He, T., Chen, C., He, J., Yang, X., & Wang, J. (2021) · Aging Cell · doi:10.1111/acel.13358 · Cited by 56 · see citing works
Zhao, X., Zhu, S., & Liu, H. (2020) · Journal of Separation Science · doi:10.1002/jssc.201901346 · Cited by 56 · see citing works
Labarre, A., Guitard, E., Tossing, G., Forest, A., Bareke, E., Labrecque, M., Tétreault, M., Ruiz, M., & Parker, J. A. (2022) · Communications Biology · doi:10.1038/s42003-022-04295-8 · Cited by 53 · see citing works
Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
Siddiqui, A., Shah, Z., Jahan, R. N., Othman, I., & Kumari, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112250 · Cited by 54 · see citing works
Wong, M. W. K., Braidy, N., Pickford, R., Vafaee, F., Crawford, J. D., Muenchhoff, J., Schofield, P. W., Attia, J., Brodaty, H., Sachdev, P. S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214141 · Cited by 51 · see citing works
Self-citationInteraction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers
Banerjee, S., Hashemi, M., Zagorski, K., & Lyubchenko, Y. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031129 · Cited by 50 · see citing works
Effects of Acupuncture on Alzheimer’s Disease: Evidence from Neuroimaging Studies
Yu, C.-C., Ma, C., Wang, H., Kong, L.-H., Zhao, Y., Shen, F., & Wu, M. (2018) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-018-2993-3 · Cited by 44 · see citing works
Chua, X. Y., Torta, F. T., Chong, J. R., Venketasubramanian, N., Hilal, S., Wenk, M. R., Chen, C., Arumugam, T. V., Herr, D. R., & Lai, M. K. P. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01359-7 · Cited by 43 · see citing works
Determination of lipid profiles of Dezhou donkey meat using an LC‐MS‐based lipidomics method
Li, M., Zhu, M., Chai, W., Wang, Y., Fan, D., Lv, M., Jiang, X., Liu, Y., Wei, Q., & Wang, C. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15917 · Cited by 39 · see citing works
Amyloid β Induces Lipid Droplet‐Mediated Microglial Dysfunction in Alzheimer’s Disease
Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K. P., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.075938 · Cited by 38 · see citing works
Chen, Y., Hu, D., Zhao, L., Tang, W., & Li, B. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339337 · Cited by 35 · see citing works
Bosoi, C. R., Vandal, M., Tournissac, M., Leclerc, M., Fanet, H., Mitchell, P. L., Verreault, M., Trottier, J., Virgili, J., Tremblay, C., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1609 · Cited by 32 · see citing works
Hunter, M., Demarais, N. J., Faull, R. L. M., Grey, A. C., & Curtis, M. A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15325 · Cited by 32 · see citing works
Wang, Q., Zang, F., He, C., Zhang, Z., Xie, C., & Initiative, A. D. N. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03786-w · Cited by 32 · see citing works
Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia
Liu, Y., Chan, D. K. Y., Thalamuthu, A., Wen, W. X., Jiang, J., Paradise, M., Lee, T., Crawford, J. D., Wong, M. W. K., Xu, Y. H., et al. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.06.001 · Cited by 31 · see citing works
Self-citationMa, Y., Shen, X., Xu, W., Huang, Y., Li, H., Tan, L., Tan, C., Dong, Q., Tan, L., Yu, J., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12041 · Cited by 31 · see citing works
Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways
Siddiqui, A., Akhtar, S., Shah, Z., Othman, I., & Kumari, Y. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200924122732 · Cited by 30 · see citing works
Grasso, G. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21566 · Cited by 30 · see citing works
Khan, M. J., Codreanu, S. G., Goyal, S., Wages, P. A., Gorti, S. K. K., Pearson, M. J., Uribe, I. R., Sherrod, S. D., MCLEAN, J. A. J., Porter, N. A., et al. (2020) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8911 · Cited by 28 · see citing works
Dulewicz, M., Kulczyńska‐Przybik, A., Słowik, A., Borawska, R., & Mroczko, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143009 · Cited by 28 · see citing works
Wang, Y., Sun, Y., Luo, Y., Peng, D., Li, X., Yang, B., Wang, Q., & Kuang, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.700587 · Cited by 28 · see citing works
Peterka, O., Maccelli, A., Jirásko, R., Vaňková, Z., Idkowiak, J., Hrstka, R., Wolrab, D., & Holčapek, M. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.342144 · Cited by 27 · see citing works
Dong, Y., Song, X., Wang, X., Wang, S., & He, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70060 · Cited by 32 · see citing works
Andrade, S., Loureiro, J. A., & Pereira, M. D. C. (2021) · ChemPhysChem · doi:10.1002/cphc.202100124 · Cited by 26 · see citing works
Tong, J., Gong, S., Zhang, Y.-S., Dong, J.-R., Zhong, X., Wei, M., & Liu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.899175 · Cited by 28 · see citing works
Afrin, M. R., Upadhyaya, P. G., Hashim, A., Bhattacharya, K., Chanu, N. R., Das, D., Khanal, P., & Deka, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102736 · Cited by 24 · see citing works
Marksteiner, J., Oberacher, H., & Humpel, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181278 · Cited by 24 · see citing works
Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids
Blank, M., & Hopf, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15216 · Cited by 24 · see citing works
Jääskeläinen, O., Hall, A., Tiainen, M., van Gils, M., Lötjönen, J. M. P., Kangas, A. J., Helisalmi, S., Pikkarainen, M., Hallikainen, M., Koivisto, A. M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191226 · Cited by 23 · see citing works
Mapstone, M. E., Gross, T. J., Macciardi, F. M., Cheema, A. K., Petersen, M. E., Head, E., Handen, B. L., Klunk, W. E., Christian, B. T., Silverman, W. P., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12028 · Cited by 23 · see citing works
Feng, J., Song, G., Wu, Y., Chen, X., Pang, J., Xu, Y., Shen, Q., Guo, S., & Zhang, M. (2021) · Food & Function · doi:10.1039/d1fo01471d · Cited by 22 · see citing works
Depciuch, J., Zawlik, I., Skrzypa, M., Pająk, J., Potocka, N., Łach, K., Bartosik-Psujek, H., Koziorowska, A. M., Kaznowska, E. B., & Cebulski, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181008 · Cited by 22 · see citing works
Pan, X., Luo, Y., Zhao, D., & Zhang, L. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03375-y · Cited by 22 · see citing works
Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism
Lee, H. N., Sim, K. M., Kim, H., Ju, J.-M., Pae, A. N., Park, J., Ryu, H., & Seong, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-51914-2 · Cited by 20 · see citing works
Preserving Brain LPC‐DHA by Plasma Supplementation Attenuates Brain Injury after Cardiac Arrest
Nishikimi, M., Shoaib, M., Choudhary, R. C., Aoki, T., Miyara, S. J., Yagi, T., Hayashida, K., Takegawa, R., Yin, T., Becker, L. B., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26296 · Cited by 20 · see citing works
Nutrition in Alzheimer’s disease: a review of an underappreciated pathophysiological mechanism
Jiang, J., Shi, H., Jiang, S., Wang, A., Zou, X., Wang, Y., Li, W., Zhang, Y., Sun, M., Ren, Q., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2276-6 · Cited by 20 · see citing works
CSF metabolites associated with biomarkers of Alzheimer’s disease pathology
Dong, R., Lu, Q., Kang, H., Suridjan, I., Kollmorgen, G., Wild, N., Deming, Y. K., Hulle, C. A. V., Anderson, R. M., Zetterberg, H., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1214932 · Cited by 20 · see citing works
Strnad, Š., Pražienková, V., Holubová, M., Sýkora, D., Cvačka, J., Maletı́nská, L., Železná, B., Kuneš, J., & Vrkoslav, V. (2020) · The Analyst · doi:10.1039/d0an00592d · Cited by 19 · see citing works
Khorani, M., Bobe, G., Matthews, D. G., Magaña, A. A., Caruso, M. A., Gray, N. E., Quinn, J. F., Stevens, J. F., Soumyanath, A., & Maier, C. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215084 · Cited by 18 · see citing works
Sakr, F., Initiative, A. D. N., Dyrba, M., Bräuer, A., & Teipel, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201504 · Cited by 19 · see citing works
Liu, L., Yue, H.-Y., Zou, J., Tang, M., Zou, F.-M., Li, Z.-L., Jia, Q., Li, Y., Kang, J., & Zuo, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1076960 · Cited by 19 · see citing works
Hassen, C. B., Machado‐Fragua, M. D., Landré, B., Fayossé, A., Dumurgier, J., Mika Kivimaki, B., Sabia, S., & Singh‐Manoux, A. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13140 · Cited by 19 · see citing works
Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins
Wong, M. W. K., Thalamuthu, A., Braidy, N., Mather, K. A., Liu, Y., Ciobanu, L. G., Baune, B. T., Armstrong, N. J., Kwok, J. B., Schofield, P. R., et al. (2020) · eLife · doi:10.7554/elife.58954 · Cited by 18 · see citing works
Self-citationHuang, W., Bartosch, A. M. W., Xiao, H., Maji, S., Youth, E. H. H., Flowers, X. E., Leskinen, S., Tomljanovic, Z., Iodice, G. M., Boyett, D. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25902-y · Cited by 17 · see citing works
Chan, H., Ke, L., Lu, H.-T., Weng, S., Chan, H., Law, S., Lin, I., Chang, C., Lu, Y., Chen, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8120542 · Cited by 18 · see citing works
Long, J., Zhang, J., Zeng, X., Wang, M., & Wang, N. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70101 · Cited by 17 · see citing works
Sakr, F. A., Dyrba, M., Bräuer, A. U., Teipel, S. J., & Initiative, A. D. N. (2022) · DZNE Pub · Cited by 17 · see citing works
Fernandes, T., Melo, T., Conde, T., Neves, B., Domingues, P. M., Resende, R., Pereira, C., Moreira, P. I., & Domingues, M. R. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16072 · Cited by 17 · see citing works
Mendes, M. P. R., de Paiva, M. J. N., Costa‐Amaral, I. C., de Carvalho, L. V. B., Figueiredo, V. O., Gonçalves, E. S., Larentis, A. L., & André, L. C. (2022) · Metabolites · doi:10.3390/metabo12100978 · Cited by 16 · see citing works
Understanding Neurodegenerative Disorders by MS-based Lipidomics
Calvano, C. D., Palmisano, F., & Cataldi, T. R. I. (2018) · Bioanalysis · doi:10.4155/bio-2018-0023 · Cited by 16 · see citing works
Granzotto, A., Bomba, M., Castelli, V., Navarra, R., Massetti, N., D’Aurora, M., ONOFRJ, M. C., Cicalini, I., Boccio, P. D., Gatta, V., et al. (2019) · Aging · doi:10.18632/aging.102191 · Cited by 16 · see citing works
Wong, M. W. K., Braidy, N., Crawford, J., Pickford, R., Song, F., Mather, K. A., Attia, J., Brodaty, H., Sachdev, P. S., & Poljak, A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190524 · Cited by 16 · see citing works
Self-citationLower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease
Zhang, M., Chen, H., Liu, G., Wang, X., Wang, Z., Feng, T., & Zhang, Y. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06113-9 · Cited by 15 · see citing works
Zhou, S., Liu, L., Zhang, Y., Zhang, Z., Li, H., Fan, F., He, J., Kang, J., & Zuo, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1104954 · Cited by 15 · see citing works
Li, Y., Wang, Y., Guo, K., Tseng, K.-F., Zhang, X., & Sun, W. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c00481 · Cited by 15 · see citing works
Moxibustion for cognitive impairment: A systematic review and meta-analysis of animal studies
Aum, S., Choe, S., Cai, M., Jerng, U. M., & Lee, J. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100680 · Cited by 15 · see citing works
Khan, M. J., Chung, N. A., Hansen, S., Dumitrescu, L. C., Hohman, T. J., Kamboh, M. I., López, O. L., & Robinson, R. A. S. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03821 · Cited by 15 · see citing works
Stepler, K. E., & Robinson, R. A. S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_1 · Cited by 15 · see citing works
Hurley, M. J., Urra, C., Garduño, B. M., Bruno, A., Kimbell, A., Wilkinson, B., Marino‐Buslje, C., Ezquer, M., Ezquer, F. E., Fernández‐Aburto, P., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.894994 · Cited by 14 · see citing works
- Authors
- Wong, M. W., Braidy, N., Poljak, A., Pickford, R., Thambisetty, M., & Sachdev, P. S.
- Affiliations
- UNSW Sydney (AU)
- National Institutes of Health (US)
- Corresponding author
- Sachdev, Perminder S.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2017-02-24
- Volume
- 13
- Issue
- 7
- Pages
- 810-827
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2589881680
- Cited by
- 223
- References
- 120
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 31 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 18 · 2018: 8 · 2017: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- handle.unsw.edu.au
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- UNSW Faculty of Medicine Research Grant
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipid dysregulation
- MeSH terms
- Alzheimer Disease, Humans, Lipids, Mass Spectrometry, Biomarkers, Lipid Metabolism
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