Cited by 224Alzheimer's disease research and treatmentsMetabolomics and Mass Spectrometry StudiesDementia and Cognitive Impairment Research

Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers

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Wong, Matthew W., Braidy, Nady, Poljak, Anne, Pickford, Russell, Thambisetty, Madhav, Sachdev, Perminder S.·2017·Alzheimer's & Dementia

Abstract

The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age-related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein- and gene-centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application.

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Crossref · 10.1016/j.jalz.2017.01.008

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120 of 120 references verified0 citation errors · 0 not checkable

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Authors
Wong, M. W., Braidy, N., Poljak, A., Pickford, R., Thambisetty, M., & Sachdev, P. S.
Affiliations
  • UNSW Sydney (AU)
  • National Institutes of Health (US)
Corresponding author
Sachdev, Perminder S.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2017-02-24
Volume
13
Issue
7
Pages
810-827
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2589881680
Cited by
223
References
120
Citations by year
2026: 19 · 2025: 18 · 2024: 31 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 18 · 2018: 8 · 2017: 3
FWCI
2.08
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders
UNSW Faculty of Medicine Research Grant
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, lipid dysregulation
MeSH terms
Alzheimer Disease, Humans, Lipids, Mass Spectrometry, Biomarkers, Lipid Metabolism

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