Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's disease
Open accessAbstract
The longitudinal assessment of episodic and semantic memory was obtained from 236 patients diagnosed with Alzheimer's disease (AD, n = 128) and with frontotemporal lobar degeneration (FTLD, n = 108), including patients with a social comportment/dysexecutive (SOC/EXEC) disorder, progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and corticobasal syndrome (CBS). At the initial assessment, AD patients obtained a lower score on the delayed free recall test than other patients. Longitudinal analyses for delayed free recall found converging performance, with all patients reaching the same level of impairment as AD patients. On the initial evaluation for delayed recognition, AD patients also obtained lower scores than other groups. Longitudinal analyses for delayed recognition test performance found that AD patients consistently produced lower scores than other groups and no convergence between AD and other dementia groups was seen. For semantic memory, there were no initial between-group differences. However, longitudinal analyses for semantic memory revealed group differences over illness duration, with worse performance for SemD versus AD, PNFA, SOC/EXEC, and CBS patients. These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype.
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Alzheimer's disease has semantic deficits of much lesser magnitude than semantic dementia.
“but with semantic deficits of a much lesser magnitude than in semantic dementia.”
From Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia (2012) · cites this paper as Xie et al., 2010
Alzheimer's disease typically displays impairments in episodic memory.
“In contrast, patients with Alzheimer's disease typically display impairments in episodic memory, but with semantic deficits of a much lesser magnitude than in semantic dementia.”
From Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia (2012) · cites this paper as Xie et al., 2010
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- Authors
- XIE, S. X., LIBON, D. J., WANG, X., MASSIMO, L., MOORE, P., VESELY, L., KHAN, A., CHATTERJEE, A., COSLETT, H. B., HURTIG, H. I., LIANG, T.-W., & GROSSMAN, M.
- Affiliations
- University of Pennsylvania (US)
- Drexel University (US)
- Thomas Jefferson University (US)
- Corresponding author
- XIE, SHARON X.
- ORCID
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-12-11
- Volume
- 16
- Issue
- 2
- Pages
- 278-286
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- PMC
- PMC2883470
- OpenAlex
- W2147585249
- Cited by
- 27
- References
- 45
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2013: 3 · 2012: 8
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cambridge
- National Institutes of Health
- National Institute on Aging (AG15116, P30AG010124, R01AG015116, P01AG017586, AG17586, AG-10124)
- National Institute of Neurological Disorders and Stroke (NS53488, NS-44266, P50NS053488, R01NS044266)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- Alzheimer's disease, frontotemporal lobar degeneration, semantic memory, episodic memory, semantic dementia, progressive nonfluent aphasia, corticobasal syndrome, delayed free recall, delayed recognition
- MeSH terms
- Aged, Alzheimer Disease, Brain, Cognition Disorders, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Mental Recall, Semantics, Severity of Illness Index, Tomography, X-Ray Computed, Tomography, Emission-Computed, Single-Photon, Pick Disease of the Brain, Positron-Emission Tomography, Frontotemporal Lobar Degeneration
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