The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Stroke and dementia risk: A systematic review and meta‐analysis
Open accessAbstract
Introduction: Stroke is an established risk factor for all‐cause dementia, though meta‐analyses are needed to quantify this risk. Methods: We searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a no‐stroke comparison group and the risk of all‐cause dementia. Random effects meta‐analysis was used to pool adjusted estimates across studies, and meta‐regression was used to investigate potential effect modifiers. Results: We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all‐cause dementia was 1.69 (95% confidence interval: 1.49–1.92; P < .00001; I 2 = 87%). For incident stroke, the pooled risk ratio was 2.18 (95% confidence interval: 1.90–2.50; P < .00001; I 2 = 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between‐study heterogeneity for prevalent stroke. Discussion: Stroke is a strong, independent, and potentially modifiable risk factor for all‐cause dementia.
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“Ischemic stroke is a strong risk factor in the development of dementia (Kuzma et al., 2018), due to lesions to cortical and subcortical areas that mediate executive functions (Kalaria et al., 2016).”
From Remembering what did not happen: the role of hypnosis in memory recall and false memories formation (2025) · cites this paper as Kuzma et al., 2018
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“One of the clearest examples of this relationship is how stroke -a cerebrovascular event that occurs when a blood vessel is blocked or bursts -markedly increases dementia risk.103”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [103]
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“One of the clearest examples of this relationship is how stroke, which occurs when a blood vessel in the brain is blocked or bursts, markedly increases dementia risk.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [113]
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2023 Alzheimer's disease facts and figures
(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
2025 Alzheimer's disease facts and figures
(2025) · Alzheimer s & Dementia · doi:10.1002/alz.70235 · Cited by 602
Epidemiology of Vascular Dementia
Wolters, F. J., & Ikram, M. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311908 · Cited by 442
Metadata
- Authors
- Kuźma, E., Lourida, I., Moore, S. F., Levine, D. A., Ukoumunne, O. C., & Llewellyn, D. J.
- Affiliations
- University of Exeter (GB)
- University of Michigan (US)
- Corresponding author
- Llewellyn, David J.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-08-31
- Volume
- 14
- Issue
- 11
- Pages
- 1416-1426
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6231970
- OpenAlex
- W2889368357
- Cited by
- 376
- References
- 80
- Citations by year
- 2026: 32 · 2025: 67 · 2024: 60 · 2023: 56 · 2022: 51 · 2021: 58 · 2020: 31 · 2019: 19 · 2018: 2
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion, cc-by-nc-nd)
- Deep Blue (University of Michigan) (submittedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Mary Kinross Charitable Trust
- Halpin Trust
- National Institute for Health Research
- National Institute on Aging
- NIA)/National Institutes of Health
- NIH (R01 AG051827)
- NINDS (R01 NS102715)
- NIA
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- stroke, dementia risk
- MeSH terms
- Age Factors, Aged, Cognition, Dementia, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Risk Factors, Vascular Diseases, Cohort Studies, Prevalence, Cognitive Dysfunction
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