Cited by 379Dementia and Cognitive Impairment ResearchAcute Ischemic Stroke ManagementNeurological Disease Mechanisms and Treatments

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Stroke and dementia risk: A systematic review and meta‐analysis

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Kuźma, Elżbieta, Lourida, Ilianna, Moore, Sarah F., Levine, Deborah A., Ukoumunne, Obioha C., Llewellyn, David J.·2018·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2018.06.3061PMC PMC6231970

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Abstract

Introduction: Stroke is an established risk factor for all‐cause dementia, though meta‐analyses are needed to quantify this risk. Methods: We searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a no‐stroke comparison group and the risk of all‐cause dementia. Random effects meta‐analysis was used to pool adjusted estimates across studies, and meta‐regression was used to investigate potential effect modifiers. Results: We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all‐cause dementia was 1.69 (95% confidence interval: 1.49–1.92; P < .00001; I 2 = 87%). For incident stroke, the pooled risk ratio was 2.18 (95% confidence interval: 1.90–2.50; P < .00001; I 2 = 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between‐study heterogeneity for prevalent stroke. Discussion: Stroke is a strong, independent, and potentially modifiable risk factor for all‐cause dementia.

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Authors: Kuźma, E., Lourida, I., Moore, S. F., Levine, D. A., Ukoumunne, O. C., & Llewellyn, D. J.
Affiliations: University of Exeter (GB)
University of Michigan (US)
Corresponding author: Llewellyn, David J.
ORCID: Kuźma, Elżbieta
Lourida, Ilianna
Moore, Sarah F.
Levine, Deborah A.
Ukoumunne, Obioha C.
Llewellyn, David J.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2018-08-31
Volume: 14
Issue: 11
Pages: 1416-1426
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2018.06.3061
PMC: PMC6231970
OpenAlex: W2889368357
Cited by: 376
References: 80
Citations by year: 2026: 32 · 2025: 67 · 2024: 60 · 2023: 56 · 2022: 51 · 2021: 58 · 2020: 31 · 2019: 19 · 2018: 2
FWCI: 4.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Open Research Exeter (University of Exeter) (acceptedVersion, cc-by-nc-nd)
Deep Blue (University of Michigan) (submittedVersion)
Figshare (submittedVersion, cc-by-nc-nd)
Newcastle University ePrints (Newcastle Univesity)
Funders: Mary Kinross Charitable Trust
Halpin Trust
National Institute for Health Research
National Institute on Aging
NIA)/National Institutes of Health
NIH (R01 AG051827)
NINDS (R01 NS102715)
NIA
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: stroke, dementia risk
MeSH terms: Age Factors, Aged, Cognition, Dementia, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Risk Factors, Vascular Diseases, Cohort Studies, Prevalence, Cognitive Dysfunction

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