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Cited by 118Dementia and Cognitive Impairment ResearchMedication Adherence and ComplianceCognitive Functions and Memory

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Adherence to multidomain interventions for dementia prevention: data from the FINGER and MAPT trials.

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Coley, Nicola, Ngandu, Tiia, Lehtisalo, Jenni, Soininen, Hilkka, Vellas, Bruno, Richard, Edo, Kivipelto, Miia, Andrieu, Sandrine, HATICE, FINGER, and MAPT/DSA groups·2019·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2019.03.005
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Abstract

INTRODUCTION: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. METHODS: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. RESULTS: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. DISCUSSION: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.

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Crossref · 10.1016/j.jalz.2019.03.005

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Metadata

Authors
Coley, N., Ngandu, T., Lehtisalo, J., Soininen, H., Vellas, B., Richard, E., Kivipelto, M., Andrieu, S., & HATICE, F.
Affiliations
  • Inserm (FR)
  • Karolinska Institutet (SE)
  • University of Helsinki (FI)
  • University of Eastern Finland (FI)
  • Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Coley, Nicola
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2019-04-29
Volume
15
Issue
6
Pages
729-741
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2019.03.005
OpenAlex
W2943103900
Cited by
118
References
49
Citations by year
2026: 9 · 2025: 22 · 2024: 21 · 2023: 12 · 2022: 20 · 2021: 18 · 2020: 13 · 2019: 3
FWCI
10.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • HAL (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion, other-oa)
  • Radboud Repository (Radboud University) (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • WOS
Funders
  • Seventh Framework Programme (305654)
  • Juho Vainion Säätiö
  • Suomen Lääketieteen Säätiö
  • Novo Nordisk Fonden
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
intervention adherence, multidomain intervention
MeSH terms
Aged, Clinical Trials as Topic, Dementia, Exercise Therapy, Female, Finland, Humans, Life Style, Risk Factors, Fatty Acids, Omega-3, Cognitive Behavioral Therapy, Outcome Assessment, Health Care

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