Cited by 118Dementia and Cognitive Impairment ResearchMedication Adherence and ComplianceCognitive Functions and Memory

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Adherence to multidomain interventions for dementia prevention: data from the FINGER and MAPT trials.

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Coley, Nicola, Ngandu, Tiia, Lehtisalo, Jenni, Soininen, Hilkka, Vellas, Bruno, Richard, Edo, Kivipelto, Miia, Andrieu, Sandrine, HATICE, FINGER, and MAPT/DSA groups·2019·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2019.03.005

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Abstract

INTRODUCTION: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. METHODS: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. RESULTS: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. DISCUSSION: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.

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Authors: Coley, N., Ngandu, T., Lehtisalo, J., Soininen, H., Vellas, B., Richard, E., Kivipelto, M., Andrieu, S., & HATICE, F.
Affiliations: Inserm (FR)
Karolinska Institutet (SE)
University of Helsinki (FI)
University of Eastern Finland (FI)
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Coley, Nicola
ORCID: Coley, Nicola
Ngandu, Tiia
Lehtisalo, Jenni
Soininen, Hilkka
Vellas, Bruno
Richard, Edo
Kivipelto, Miia
Andrieu, Sandrine
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2019-04-29
Volume: 15
Issue: 6
Pages: 729-741
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2019.03.005
OpenAlex: W2943103900
Cited by: 118
References: 49
Citations by year: 2026: 9 · 2025: 22 · 2024: 21 · 2023: 12 · 2022: 20 · 2021: 18 · 2020: 13 · 2019: 3
FWCI: 10.58
Type: journal article
Language: en
Open access: green
pure.amsterdamumc.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
HAL (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Työväentutkimus Vuosikirja (submittedVersion, other-oa)
Radboud Repository (Radboud University) (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
WOS
Funders: Seventh Framework Programme (305654)
Juho Vainion Säätiö
Suomen Lääketieteen Säätiö
Novo Nordisk Fonden
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: intervention adherence, multidomain intervention
MeSH terms: Aged, Clinical Trials as Topic, Dementia, Exercise Therapy, Female, Finland, Humans, Life Style, Risk Factors, Fatty Acids, Omega-3, Cognitive Behavioral Therapy, Outcome Assessment, Health Care

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Adherence to multidomain interventions for dementia prevention: data from the FINGER and MAPT trials.

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