Motoric cognitive risk syndrome and predictors of transition to dementia: a multicenter study
Open accessAbstract
Introduction: To report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait. Methods: We examined if cognitive or motoric impairments predicted transition to dementia in 610 older adults with MCR from three cohorts. Association of cognitive (logical memory, clinical dementia rating, cognitive complaint severity, and Mini–Mental State Examination) and motoric factors (gait velocity) with dementia risk was computed using Cox models. Results: There were 156 incident dementias (134 Alzheimer's disease). In the pooled sample, logical memory (adjusted hazard ratio [aHR] 0.91), cognitive complaint severity (aHR 1.53), and Mini–Mental State Examination (aHR 0.75) predicted transition of MCR to dementia. Clinical dementia rating score ≥0.5 predicted dementia (aHR 3.18) in one cohort. Gait velocity did not predict dementia. Discussion: While MCR is a motoric‐based predementia syndrome, severity of cognitive but not motoric impairments predicts conversion to dementia.
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The STAMINA study was a 12-week, single-arm, open-label, pre-post pilot study in 12 older adults with slow gait speed and MCI.
“The STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Ageing) study is a 12-week, single-arm, open-label, pre-post pilot study implementing intermittent doses of DQ in 12 older adults aged ≥65 years with slow gait speed and MCI, which are both precursors to the development of Alzheimer’s disease.”
From A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease (2025) · cites this paper as [9]
The Methods describe an analysis of three aging cohorts, not a STAMINA pilot study. Searches for STAMINA, its 12-week design, and intermittent DQ dosing found no passage addressing the claimed trial. The Introduction discusses slow gait and dementia risk, but does not establish the study details in the claim. (LLM, conf=0.76)
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How physical activity influences motoric cognitive risk syndrome in older adults
Chen, X., Zhang, Z., Zhang, Y., Deng, L., Guo, H., Zou, W., & Wang, D. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06824-6
Zhang, Y., Ma, L., Ma, Y., Chang, J., Zhao, Y., Gao, X. J., Wu, Y., Xing, Y., Guo, Y., Ma, L., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1787145
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Khodabakhshi, H., Rashedi, V., Sharifi, F., & Foroughan, M. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-02073-5
Hu, F., Zhang, Y., Zhang, G., Zhou, L., Deng, Y., Li, D., Deng, X., Huang, T., Fu, C., Dong, B., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-115160
- Authors
- Verghese, J., Wang, C., Bennett, D. A., Lipton, R. B., Katz, M. J., & Ayers, E.
- Affiliations
- Albert Einstein College of Medicine (US)
- Rush University Medical Center (US)
- Corresponding author
- Verghese, Joe
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2019-06
- Volume
- 15
- Issue
- 7
- Pages
- 870-877
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6646063
- OpenAlex
- W2946913613
- Cited by
- 79
- References
- 27
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 7 · 2022: 19 · 2021: 11 · 2020: 10
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R56AG057548)
- Illinois Department of Public Health (P30AG10161, R01AG15819, R01AG17917, R01AG34374, R01AG33678)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Older Adults Driving Studies
- Keywords
- motoric cognitive risk syndrome
- MeSH terms
- Age Factors, Aged, Cognition Disorders, Dementia, Female, Gait, Humans, Male, Neuropsychological Tests, Prospective Studies, Risk Factors, United States, Prodromal Symptoms
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