The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Ablation of Perivascular Hepatic Malignant Tumors with Irreversible Electroporation
Abstract
BACKGROUND: Ablation is increasingly used to treat primary and secondary liver cancer. Ablation near portal pedicles and hepatic veins is challenging. Irreversible electroporation (IRE) is a new ablation technique that does not rely on heat and, in animals, appears to be safe and effective when applied near hepatic veins and portal pedicles. This study evaluated the safety and short-term outcomes of IRE to ablate perivascular malignant liver tumors. STUDY DESIGN: A retrospective review of patients treated with IRE between January 1, 2011 and November 2, 2011 was performed. Patients were selected for IRE when resection or thermal ablation was not indicated due to tumor location. Treatment outcomes were classified by local, regional, and systemic recurrence and complications. Local failure was defined as abnormal enhancement at the periphery of an ablation defect on post-procedure contrast imaging. RESULTS: Twenty-eight patients had 65 tumors treated. Twenty-two patients (79%) were treated via an open approach and 6 (21%) were treated percutaneously. Median tumor size was 1 cm (range 0.5 to 5 cm). Twenty-five tumors were <1 cm from a major hepatic vein; 16 were <1 cm from a major portal pedicle. Complications included 1 intraoperative arrhythmia and 1 postoperative portal vein thrombosis. Overall morbidity was 3%. There were no treatment-associated mortalities. At median follow-up of 6 months, there was 1 tumor with persistent disease (1.9%) and 3 tumors recurred locally (5.7%). CONCLUSIONS: This early analysis of IRE treatment of perivascular malignant hepatic tumors demonstrates safety for treating liver malignancies. Larger studies and longer follow-up are necessary to determine long-term efficacy.
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Cites
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Livraghi, T., Solbiati, L., Meloni, M. F., Gazelle, G. S., Halpern, E. F., & Goldberg, S. N. (2003) · Radiology · doi:10.1148/radiol.2262012198 · Cited by 1,298
Irreversible Electroporation: A New Ablation Modality — Clinical Implications
Rubinsky, B., Onik, G., & Mikus, P. (2007) · Technology in Cancer Research & Treatment · doi:10.1177/153303460700600106 · Cited by 781
Mulier, S., Ni, Y., Jamart, J., Ruers, T., Marchal, G., & Michel, L. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000171032.99149.fe · Cited by 688
Tumor Ablation with Irreversible Electroporation
Al-Sakere, B., André, F., Bernat, C., Connault, E., Opolon, P., Davalos, R. V., Rubinsky, B., & Mir, L. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001135 · Cited by 490
Investigation of the Safety of Irreversible Electroporation in Humans
Thomson, K. R., Cheung, W., Ellis, S. J., Federman, D., Kavnoudias, H., Loader-Oliver, D., Roberts, S., Evans, P., Ball, C., & Haydon, A. (2011) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2010.12.014 · Cited by 466
Lu, D. S. K., Yu, N. C., Raman, S. S., Limanond, P., Lassman, C., Murray, K., Tong, M. J., Amado, R. G., & Busuttil, R. W. (2005) · Radiology · doi:10.1148/radiol.2343040153 · Cited by 387
Advanced Hepatic Ablation Technique for Creating Complete Cell Death: Irreversible Electroporation
Lee, E. W., Chen, C., Prieto, V. E., Dry, S. M., Loh, C. T., & Kee, S. T. (2010) · Radiology · doi:10.1148/radiol.10090337 · Cited by 330
Cancer Cells Ablation with Irreversible Electroporation
Miller, L., Leor, J., & Rubinsky, B. (2005) · Technology in Cancer Research & Treatment · doi:10.1177/153303460500400615 · Cited by 298
Deodhar, A., Dickfeld, T., Single, G. W., Hamilton, W. C., Thornton, R. H., Sofocleous, C. T., Maybody, M., Gónen, M., Rubinsky, B., & Solomon, S. B. (2011) · American Journal of Roentgenology · doi:10.2214/ajr.10.4490 · Cited by 196
Self-citation
Cited by
A Review of Basic to Clinical Studies of Irreversible Electroporation Therapy
Jiang, C., Davalos, R. V., & Bischof, J. C. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2367543 · Cited by 332
Dhir, M., Melin, A. A., Douaiher, J., Lin, C., Zhen, W. (., Hussain, S. M., Geschwind, J.-F. H., Doyle, M. B. M., Abou-Alfa, G. K., & Are, C. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001556 · Cited by 285
Irreversible electroporation (NanoKnife) in cancer treatment
Jourabchi, N., Beroukhim, K., Tafti, B. A., Kee, S. T., & Lee, E. W. (2014) · Gastrointestinal Intervention · doi:10.1016/j.gii.2014.02.002 · Cited by 99
Metadata
- Authors
- Kingham, P. T., Karkar, A. M., D'Angelica, M. I., Allen, P. J., DeMatteo, R. P., Getrajdman, G. I., Sofocleous, C. T., Solomon, S. B., Jarnagin, W. R., & Fong, Y.
- Venue
- Journal of the American College of Surgeons
- Published
- 2012-09
- Volume
- 215
- Issue
- 3
- Pages
- 379-387
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W1963943534
- Cited by
- 274
- References
- 18
- FWCI
- 25.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kingham, P. T., Karkar, A. M., D'Angelica, M. I., Allen, P. J., DeMatteo, R. P., Getrajdman, G. I., Sofocleous, C. T., Solomon, S. B., Jarnagin, W. R., & Fong, Y. (2012). Ablation of Perivascular Hepatic Malignant Tumors with Irreversible Electroporation. Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2012.04.029
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