The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dose-Responsive Effect of Psychotropic Drug Use and Subsequent Dementia: A Nationwide Propensity Score Matched Case-Control Study in Taiwan
Abstract
Objective To test the hypothesis that the load of psychotropic agents was associated with subsequent dementia occurrence by a nationwide database. Design Propensity score matched case-control study. Setting National Health Insurance Research database. Participants A total of 32,649 older people with dementia and 32,649 matched dementia-free older people. Measurements Use of psychotropic drugs (anxiolytics, antipsychotics, hypnotics, and antidepressants), defined daily dose (DDD) of psychotropic drugs, diagnosis of dementia, and propensity score. Intervention None. Results Compared with nonusers, ever use of psychotropic agents was associated with higher odds of subsequent dementia [adjusted odds ratio (OR): 3.73; 95% confidence interval (CI) (3.59-3.88)]. Significantly, the association was stronger with longer term exposure to psychotropic agents. The ORs at exposures of 180 days, were 3.14 (95% CI 3.01-3.28); 5.48 (5.07-5.93); and 7.54 (6.73-8.44), respectively. A similar and stronger association was identified when cumulative dose was used to measure the exposure of psychotropic agents [ 180 DDDs, 7.35 (6.29-8.58)]. Conclusions We found that a higher burden of psychotropic agents was strongly associated with a higher odds of subsequent dementia. Careful monitoring of any elderly who is prescribed or uptitrated psychotropic agents is highly recommended, especially those who combine use of more than one agent. Furthermore, providing timely assessment for cognitive function fo…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hsiao et al. reported that a higher ratio of dementia cases had a history of taking antidepressants (11.41%) compared to control (4.88%) (p < .001).
“Consistent with our results, Hsiao et al. reported that a higher ratio of dementia cases had a history of taking antidepressants (11.41%) compared to control (4.88%) ( p < .001) [51].”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [51]
A study using Taiwan's NHIRD showed that populations with a dementia diagnosis had a higher ratio of taking antidepressants.
“(a) a study using Taiwan's NHIRD which showed that populations with a dementia diagnosis had a higher ratio of taking antidepressants [51]”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [51]
Citations
Cites
Does Anxiety Affect Risk of Dementia? Findings From the Caerphilly Prospective Study
Gallacher, J., Bayer, A., Fish, M., Pickering, J., Pedro, S., Dunstan, F., Ebrahim, S., & Ben-Shlomo, Y. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a6177c · Cited by 137
Flagged first, then by citations
Research works printed but not linked: 28
- Woo, 2013, Meeting the needs of an aging population in China: Public health and policy implications, J Clin Gerontol Geriatr, 4, 31, 10.1016/j.jcgg.2013.02.001 · DOI
- Miu, 2012, Sleep disturbances among a group of dementia participants, J Clin Gerontol Geriatr, 3, 105, 10.1016/j.jcgg.2012.04.008 · DOI
- Chu, 2013, Insomnia of older people and use of benzodiazepines in Taiwan, J Clin Gerontol Geriatr, 4, 67, 10.1016/j.jcgg.2013.04.005 · DOI
- Hsiao, 2013, Ten-year trend in prescriptions of z-hypnotics among the elderly: A nationwide, cross-sectional study in Taiwan, J Clin Gerontol Geriatr, 4, 37, 10.1016/j.jcgg.2012.12.001 · DOI
- Gustafsson, 2013, Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units, BMC Pharmacol Toxicol, 14, 10, 10.1186/2050-6511-14-10 · DOI
- Koyama, 2013, Ten-year trajectory of potentially inappropriate medications in very old women: Importance of cognitive status, J Am Geriatr Soc, 61, 258, 10.1111/jgs.12093 · DOI
- Fick, 2003, Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts, Arch Intern Med, 163, 2716, 10.1001/archinte.163.22.2716 · DOI · Paper page
- Billioti de Gage, 2012, Benzodiazepine use and risk of dementia: prospective population based study, BMJ, 345, e6231, 10.1136/bmj.e6231 · DOI · Paper page
- Bocti, 2013, Benzodiazepine and dementia: A time for reflection, Maturitas, 75, 105, 10.1016/j.maturitas.2013.03.001 · DOI
- Bocti, 2012, Research paper most likely shows that benzodiazepines are used to treat early symptoms of dementia, BMJ, 345, e7986, 10.1136/bmj.e7986 · DOI
- Barbui, 2013, Benzodiazepines and risk of dementia: true association or reverse causation?, Epidemiol Psychiatr Sci, 22, 307, 10.1017/S2045796013000358 · DOI
- Gallacher, 2012, Benzodiazepine use and risk of dementia: Evidence from the Caerphilly Prospective Study (CaPS), J Epidemiol Community Health, 66, 869, 10.1136/jech-2011-200314 · DOI
- Paterniti, 2002, Long-term benzodiazepine use and cognitive decline in the elderly: The Epidemiology of Vascular Aging Study, J Clin Psychopharmacol, 22, 285, 10.1097/00004714-200206000-00009 · DOI
- Wu, 2009, The association between dementia and long-term use of benzodiazepine in the elderly: Nested case-control study using claims data, Am J Geriatr Psychiatry, 17, 614, 10.1097/JGP.0b013e3181a65210 · DOI
- Verdoux, 2005, Is benzodiazepine use a risk factor for cognitive decline and dementia? A literature review of epidemiological studies, Psychol Med, 35, 307, 10.1017/S0033291704003897 · DOI
- Lagnaoui, 2002, Benzodiazepine use and risk of dementia: a nested case-control study, J Clin Epidemiol, 55, 314, 10.1016/S0895-4356(01)00453-X · DOI
- Amieva, 2008, Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms, Ann Neurol, 64, 492, 10.1002/ana.21509 · DOI · Paper page
- Hsiao, 2007, Using Taiwan's national health insurance research databases for pharmacoepidemiology research, J Food Drug Anal, 15, 99
- Chen, 2011, Alendronate and risk of esophageal cancer: a nationwide population-based study in Taiwan, J Am Geriatr Soc, 59, 2379, 10.1111/j.1532-5415.2011.03693.x · DOI
- Hsiao, 2011, Hip and subtrochanteric or diaphyseal femoral fractures in alendronate users: A 10-year, nationwide retrospective cohort study in Taiwanese women, Clin Ther, 33, 1659, 10.1016/j.clinthera.2011.09.006 · DOI
- Huang, 2010, Osteoporosis treatment and atrial fibrillation: alendronate versus raloxifene, Menopause, 17, 57, 10.1097/gme.0b013e3181b34749 · DOI
- Lin, 2012, Age, dementia and care patterns after admission for acute coronary syndrome: An analysis from a nationwide cohort under the national health insurance coverage, Drugs Aging, 29, 819, 10.1007/s40266-012-0011-6 · DOI
- Mazzucco, 2008, Antipsychotic drugs and cerebrovascular events in elderly patients with dementia: A systematic review, Mini Rev Med Chem, 8, 776, 10.2174/138955708784912175 · DOI
- Lagnaoui, 2009, The risk of cognitive impairment in older community-dwelling women after benzodiazepine use, Age Ageing, 38, 226, 10.1093/ageing/afn277 · DOI
- Potvin, 2011, Anxiety disorders, depressive episodes and cognitive impairment no dementia in community-dwelling older men and women, Int J Geriatr Psychiatry, 26, 1080, 10.1002/gps.2647 · DOI
- Wu, 2013, Increased risk of developing dementia in patients with bipolar disorder: A nested matched case-control study, Bipolar Disord, 15, 787, 10.1111/bdi.12116 · DOI
- Liperoti, 2008, Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD), Curr Neuropharmacol, 6, 117, 10.2174/157015908784533860 · DOI
- Sink, 2005, Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence, JAMA, 293, 596, 10.1001/jama.293.5.596 · DOI · Paper page
Cited by
Sorted by citations
Then, C.-K., Chi, N.-F., Chung, K.-H., Kuo, L., Liu, K.-H., Hu, C.-J., Shen, S.-C., & Lin, Y.-K. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175187 · Cited by 35
Metadata
- Authors
- Hsiao, F.-Y., Peng, L.-N., Lin, M.-H., & Chen, L.-K.
- Affiliations
- National Taiwan University (TW)
- Taipei Veterans General Hospital (TW)
- Corresponding author
- Chen, Liang-Kung
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 15
- Issue
- 7
- Pages
- 509-513
- ISSN
- 1525-8610 (ISSN-L)
- OpenAlex
- W1989469109
- Cited by
- 20
- References
- 1
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health Insurance Association
- National Health Research Institutes
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- psychotropic drugs, dementia, dose-response relationship, defined daily doses, cumulative drug exposure, anxiolytics, antipsychotic drugs, hypnotics, antidepressants, older adults, polypharmacy, cognitive function monitoring
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Dose-Response Relationship, Drug, Female, Humans, Male, Psychotropic Drugs, Taiwan, Case-Control Studies, Databases, Factual, Propensity Score
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
