Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
Abstract
OBJECTIVE: Whereas cognitive deficits are known to be detectable long before the typical symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to determine when cognitive functioning actually begins to decline before dementia. Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD. METHODS: This study relies on a case-control sample selected from the PAQUID cohort. Of the 3,777 initial subjects of the cohort, 350 subjects experienced development of AD during the 14 years of follow-up. The cases were matched to 350 elderly control subjects. The evolution of scores on cognitive, functional, and depression scales was described throughout the 14-year follow-up using a semiparametric extension of the mixed-effects linear model. RESULTS: The first decline in cognitive performances appeared as early as 12 years before dementia in measures of semantic memory and conceptual formation. Then, more global deficits appeared that were concomitant with an increase in memory complaints and depressive symptoms. About 2 years later, as a consequence of cognitive dysfunction, the subjects started to become slightly dependent in their activities of daily living. In the last 3 years, the impairment significantly worsened until the subjects reached the dementia phase. INTERPRETATION: This approach, describing the 14 years preceding dementia, provides a clear illustration of the particularly long and progressive prodromal phase of AD, and shows the successive emergence of cognitive deficits, depressive symptoms, and functional impairment during this phase.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various studies suggest the pre-dementia period of cognitive decline lasts at least a decade and perhaps many decades.
“Various studies suggest this pre-dementia period of cognitive decline lasts at least a decade and perhaps even many decades [83–86].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [86]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540 · see citing works
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
The processing-speed theory of adult age differences in cognition
Salthouse, T. A. (1996) · Psychological Review · doi:10.1037/0033-295x.103.3.403 · Cited by 5,568 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Self-citationResearch criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411 · see citing works
Self-citationMcKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331 · see citing works
Functional anatomy of a common semantic system for words and pictures
Vandenberghe, R. R., Price, C. J., Wise, R., Josephs, O., & Frackowiak, R. S. J. (1996) · Nature · doi:10.1038/383254a0 · Cited by 1,172 · see citing works
Standardizing Assessment of Elderly People in Acute Care: The interRAI Acute Care Instrument
Gray, L., Bernabei, R., Berg, K., Finne‐Soveri, H., Fries, B. E., Hirdes, J. P., Jónsson, P. V., Morris, J. N., Steel, K., & Ariño‐Blasco, S. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01590.x · Cited by 967 · see citing works
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
Delacourte, A., David, J. P., Sergeant, N., Buée, L., Wattez, A., Vermersch, P., Ghozali, F., Fallet-Bianco, C., Pasquier, F., Lebert, F., et al. (1999) · Neurology · doi:10.1212/wnl.52.6.1158 · Cited by 828 · see citing works
The Preclinical Phase of Alzheimer Disease: A 22-Year Prospective Study of the Framingham Cohort
Elias, M. F., Beiser, A., Wolf, P. A., Au, R., White, R. F., & D'Agostino, R. B. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.808 · Cited by 716 · see citing works
Snowdon, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530310034029 · Cited by 696 · see citing works
The Set Test as an Aid to the Detection of Dementia in Old People
Isaacs, B., & Kennie, A. T. (1973) · The British Journal of Psychiatry · doi:10.1192/bjp.123.4.467 · Cited by 617 · see citing works
Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
Guillozet-Bongaarts, A. L., Weıntraub, S., Mash, D. C., & Mesulam, M. M. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.729 · Cited by 572 · see citing works
Stability of the preclinical episodic memory deficit in Alzheimer's disease
Bäckman, L., Small, B. J., & Fratiglioni, L. (2001) · Brain · doi:10.1093/brain/124.1.96 · Cited by 449 · see citing works
The 'Preclinical Phase' of Probable Alzheimer's Disease
Linn, R. T. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540290075020 · Cited by 437 · see citing works
Amieva, H., Jacqmin‐Gadda, H., Orgogozo, J., Carret, N. L., Helmer, C., Letenneur, L., Barberger‐Gateau, P., Fabrigoule, C., & Dartigues, J. (2005) · Brain · doi:10.1093/brain/awh451 · Cited by 437 · see citing works
Self-citationBarberger‐Gateau, P., Commenges, D., Gagnon, M., Letenneur, L., Sauvel, C., & Dartigues, J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01802.x · Cited by 427 · see citing works
Self-citationNeuropsychological prediction of dementia and the absence of dementia in healthy elderly persons
Masur, D. M., Sliwinski, M., Lipton, R. B., Blau, A. D., & Crystal, H. A. (1994) · Neurology · doi:10.1212/wnl.44.8.1427 · Cited by 422 · see citing works
Is depression a risk factor for dementia or cognitive decline?
Jorm, A. F. (2000) · Gerontology · doi:10.1159/000022163 · Cited by 416 · see citing works
Neuropsychological detection and characterization of preclinical Alzheimer’s disease
Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995) · Neurology · doi:10.1212/wnl.45.5.957 · Cited by 409 · see citing works
Letenneur, L., Gilleron, V, Commenges, D., Helmer, C., Orgogozo, J. M., & Dartigues, J. F. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.177 · Cited by 406 · see citing works
Self-citationProblems in the measurement of cognitive deficits.
Chapman, L. J., & Chapman, J. P. (1973) · Psychological Bulletin · doi:10.1037/h0034541 · Cited by 393 · see citing works
Relation of Education and Occupation-based Socioeconomic Status to Incident Alzheimer's Disease
Karp, A. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh018 · Cited by 383 · see citing works
Patterns of Cognitive Decline in Presymptomatic Alzheimer Disease
Chen, P., Ratcliff, G. G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.9.853 · Cited by 369 · see citing works
Riley, K. P., Snowdon, D. A., Desrosiers, M. F., & Markesbery, W. R. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.019 · Cited by 303 · see citing works
A 5-year longitudinal study of the Mini-Mental State Examination in normal aging.
Jacqmin-Gadda, H., Fabrigoule, C., Commenges, D., & Dartigues, J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009137 · Cited by 293 · see citing works
Self-citationLongitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
Storandt, M., Grant, E., Miller, J. P., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228231.26111.6e · Cited by 285 · see citing works
Disease-modifying therapies for Alzheimer disease
Cummings, J. L., Doody, R. S., & Clark, C. (2007) · Neurology · doi:10.1212/01.wnl.0000295996.54210.69 · Cited by 281 · see citing works
Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years
Tierney, M. C., Yao, C., Kiss, A., & McDowell, I. (2005) · Neurology · doi:10.1212/01.wnl.0000163773.21794.0b · Cited by 274 · see citing works
Mitchell, T. W., Mufson, E. J., Schneider, J. A., Cochran, E. J., Nissanov, J., Han, L., Bienias, J. L., Lee, V. M. ‐., Trojanowski, J. Q., Bennett, D. A., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10086 · Cited by 249 · see citing works
Cognitive Markers Preceding Alzheimer's Dementia in the Healthy Oldest Old
Howieson, D. B., Dame, A., Camicioli, R. M., Sexton, G. J., Payami, H., & Kaye, J. A. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb03091.x · Cited by 211 · see citing works
Noppeney, U., Patterson, K., TYLER, L. K., Moss, H. E., Stamatakis, E. A., Bright, P., Mummery, C. J., & Price, C. J. (2006) · Brain · doi:10.1093/brain/awl344 · Cited by 191 · see citing works
The Paquid Epidemiological Program on Brain Ageing
Dartigues, J.-F., Gagnon, M., Barberger‐Gateau, P., Letenneur, L., Commenges, D., Sauvel, C., Michel, P., & Salamon, R. (1992) · Neuroepidemiology · doi:10.1159/000110955 · Cited by 187 · see citing works
Self-citationThe anatomy of semantic knowledge: Medial vs. lateral temporal lobe
Levy, D. A., Bayley, P. J., & Squire, L. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401679101 · Cited by 156 · see citing works
Hof, P. R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530330070019 · Cited by 118 · see citing works
Holtzer, R., Scarmeas, N., Wegesin, D. J., Albert, M., Brandt, J., Dubois, B., Hadjigeorgiou, G. M., & Stern, Y. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00535.x · Cited by 106 · see citing works
Hall, C. B., Ying, J., Kuo, L., Sliwinski, M. J., Herman Buschke, L., Katz, M. J., & Lipton, R. B. (2001) · Statistics in Medicine · doi:10.1002/sim.1113 · Cited by 90 · see citing works
Tranel, D., Grabowski, T. J., Lyon, J., et al. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929055002508 · Cited by 76 · see citing works
Early detection of Alzheimer's disease using the Cambridge Cognitive Examination (CAMCOG)
Schmand, B. A., Walstra, G. J. M., Lindeboom, J., Teunisse, S., & Jonker, C. (2000) · Psychological Medicine · doi:10.1017/s0033291799002068 · Cited by 68 · see citing works
Amieva, H., Gaëstel, Y., & Dartigues, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.302 · Cited by 16 · see citing works
Self-citationPenalized likelihood approach to estimate a smooth mean curve on longitudinal data
Jacqmin‐Gadda, H., Joly, P., Commenges, D., Binquet, C., & Chêne, G. (2002) · Statistics in Medicine · doi:10.1002/sim.1225 · Cited by 15 · see citing works
Self-citation221 A five-year longitudinal study of mini-mental state examination in normal aging
Jacgmin-Gadda, H., Fabrigoule, C., Commenges, D., et al. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)80223-5 · Cited by 12 · see citing works
Depressive Symptoms and Cognitive Decline in Nondemented Elderly Women: A Prospective Study
Yaffe, K., Blackwell, T., Gore, R., Sands, L., Reus, V., & Browner, W. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.425 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Self-citationDefeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works
The characterisation of subjective cognitive decline
Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., Rabin, L., Rentz, D. M., Rodriguez-Gomez, O., Saykin, A. J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30368-0 · Cited by 1,389 · see citing works
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261 · see citing works
Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study
Gray, S. L., Anderson, M. L., Dublin, S., Hanlon, J. T., Hubbard, R., Walker, R., Yu, O., Crane, P. K., & Larson, E. B. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.7663 · Cited by 1,111 · see citing works
The Preclinical Alzheimer Cognitive Composite: Measuring Amyloid-Related Decline
Donohue, M. C., Sperling, R. A., Salmon, D. P., Rentz, D. M., Raman, R., Thomas, R. G., Weiner, M., & Aisen, P. S. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.803 · Cited by 860 · see citing works
The pathological process underlying Alzheimer’s disease in individuals under thirty
Braak, H., & Del Tredici, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0789-4 · Cited by 812 · see citing works
Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia
Féart, C. (2009) · JAMA · doi:10.1001/jama.2009.1146 · Cited by 757 · see citing works
Jekel, K., Damian, M., Wattmo, C., Hausner, L., Bullock, R., Connelly, P. J., Dubois, B., Eriksdotter, M., Ewers, M., Graessel, E., et al. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0099-0 · Cited by 640 · see citing works
Self-citationTrajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study
Singh-Manoux, A., Dugravot, A., Fournier, A., Abell, J., Ebmeier, K., Kivimäki, M., & Sabia, S. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0660 · Cited by 529 · see citing works
Benzodiazepine use and risk of dementia: prospective population based study
Billioti de Gage, S., Begaud, B., Bazin, F., Verdoux, H., Dartigues, J.-F., Peres, K., Kurth, T., & Pariente, A. (2012) · BMJ · doi:10.1136/bmj.e6231 · Cited by 436 · see citing works
Self-citationObesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II study
Singh‐Manoux, A., Dugravot, A., Shipley, M., Brunner, E. J., Elbaz, A., Sabia, S., & Kivimaki, M. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.06.2637 · Cited by 401 · see citing works
Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment
Dotson, V. M., Beydoun, M. A., & Zonderman, A. B. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e62124 · Cited by 385 · see citing works
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
Wilson, R. S., Leurgans, S. E., Boyle, P. A., & Bennett, D. A. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.31 · Cited by 346 · see citing works
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · see citing works
“Various studies suggest this pre-de-mentia period of cognitive decline lasts at least a decade and perhaps even many decades [83 – 86].”
BackgroundGlucose metabolism, gray matter structure, and memory decline in subjective memory impairment
Scheef, L., Spottke, A., Daerr, M., Joe, A., Striepens, N., Kölsch, H., Popp, J., Daamen, M., Gorris, D., Heneka, M. T., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31826c1a8d · Cited by 277 · see citing works
Abell, J. G., Kivimäki, M., Dugravot, A., Tabak, A. G., Fayosse, A., Shipley, M., Sabia, S., & Singh-Manoux, A. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy288 · Cited by 252 · see citing works
Gray, S. L., Dublin, S., Yu, O., Walker, R., Anderson, M., Hubbard, R. A., Crane, P. K., & Larson, E. B. (2016) · BMJ · doi:10.1136/bmj.i90 · Cited by 233 · see citing works
Social participation and risk of developing dementia
Sommerlad, A., Kivimäki, M., Larson, E. B., Röhr, S., Shirai, K., Singh-Manoux, A., & Livingston, G. (2023) · Nature Aging · doi:10.1038/s43587-023-00387-0 · Cited by 207 · see citing works
Estimating long‐term multivariate progression from short‐term data
Donohue, M. C., Jacqmin‐Gadda, H., Le Goff, M., Thomas, R. G., Raman, R., Gamst, A. C., Beckett, L. A., Jack, C. R., Weiner, M. W., Dartigues, J., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.10.003 · Cited by 197 · see citing works
Self-citationAtrial fibrillation as a risk factor for cognitive decline and dementia
Singh-Manoux, A., Fayosse, A., Sabia, S., Canonico, M., Bobak, M., Elbaz, A., Kivimäki, M., & Dugravot, A. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx208 · Cited by 186 · see citing works
Clinical-pathologic study of depressive symptoms and cognitive decline in old age
Wilson, R. S., Capuano, A. W., Boyle, P. A., Hoganson, G. M., Hizel, L. P., Shah, R. C., Nag, S., Schneider, J. A., Arnold, S. E., & Bennett, D. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000715 · Cited by 165 · see citing works
Braak, H., & Del Tredici, K. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy152 · Cited by 148 · see citing works
Lucchetta, R. C., da Mata, B. P. M., & Mastroianni, P. D. C. (2018) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2170 · Cited by 130 · see citing works
Stafford, J., Chung, W. T., Sommerlad, A., Kirkbride, J. B., & Howard, R. (2022) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5711 · Cited by 126 · see citing works
Hippocampal Subfield Volumetry and 3D Surface Mapping in Subjective Cognitive Decline
Perrotin, A., de Flores, R., Lamberton, F., Poisnel, G., La Joie, R., de la Sayette, V., Mézenge, F., Tomadesso, C., Landeau, B., Desgranges, B., et al. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150087 · Cited by 119 · see citing works
Analysis of multivariate mixed longitudinal data: a flexible latent process approach
Proust‐Lima, C., Amieva, H., & Jacqmin‐Gadda, H. (2013) · British Journal of Mathematical and Statistical Psychology · doi:10.1111/bmsp.12000 · Cited by 110 · see citing works
Self-citationBartus, R. T., & Johnson, E. M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.027 · Cited by 97 · see citing works
The dynamics of biomarkers across the clinical spectrum of Alzheimer's disease
Hadjichrysanthou, C., Evans, S., Bajaj, S., Siakallis, L. C., McRae-McKee, K., de Wolf, F., Anderson, R. M., & Initiative, T. A. D. N. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00636-z · Cited by 86 · see citing works
Omega-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression
Samieri, C., Féart, C., Proust-Lima, C., Peuchant, E., Dartigues, J.-F., Amieva, H., & Barberger-Gateau, P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.020 · Cited by 84 · see citing works
Self-citationSanz, C. M., Ruidavets, J.-B., Bongard, V., Marquié, J.-C., Hanaire, H., Ferrières, J., & Andrieu, S. (2013) · Diabetes Care · doi:10.2337/dc12-1017 · Cited by 60 · see citing works
Liang, X., Guo, Q., Luo, J., Li, F., Ding, D., Zhao, Q., & Hong, Z. (2016) · BMC Neurology · doi:10.1186/s12883-016-0712-2 · Cited by 53 · see citing works
Grotz, C., Meillon, C., Amieva, H., Stern, Y., Dartigues, J.-F., Adam, S., & Letenneur, L. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0599-4 · Cited by 52 · see citing works
Self-citationMartínez de Toda, I., Miguélez, L., Vida, C., Carro, E., & De la Fuente, M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190198 · Cited by 40 · see citing works
Wu, J., Hasselgren, C., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I., & Halleröd, B. (2020) · Aging & Mental Health · doi:10.1080/13607863.2018.1531368 · Cited by 18 · see citing works
Lee, S.-H., Jeon, S. W., Shin, C., Pae, C.-U., Patkar, A. A., Masand, P. S., An, H., & Han, C. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0368 · Cited by 12 · see citing works
Neurodegenerative Disorders of Speech and Language: Non-language-dominant Diseases
García, A. M., DeLeon, J., & Tee, B. L. (2022) · Encyclopedia of Behavioral Neuroscience, 2nd edition · doi:10.1016/b978-0-12-819641-0.00042-6 · Cited by 10 · see citing works
- Authors
- Amieva, H., Le Goff, M., Millet, X., Orgogozo, J. M., Pérès, K., Barberger‐Gateau, P., Jacqmin‐Gadda, H., & Dartigues, J. F.
- Affiliations
- Inserm (FR)
- Corresponding author
- Amieva, Hélène
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2008-11
- Volume
- 64
- Issue
- 5
- Pages
- 492-498
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2107381357
- Cited by
- 737
- References
- 47
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 30 · 2023: 32 · 2022: 45 · 2021: 38 · 2020: 51 · 2019: 41 · 2018: 45 · 2017: 43 · 2016: 40 · 2015: 58 · 2014: 56 · 2013: 58 · 2012: 43
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- prodromal Alzheimer's disease, Alzheimer's disease, dementia onset, cognitive decline, semantic memory, concept formation, memory impairment, depressive symptoms, activities of daily living, functional disability, PAQUID cohort, longitudinal follow-up
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cognition Disorders, Depressive Disorder, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Memory Disorders, Neuropsychological Tests, Predictive Value of Tests, Time Factors, Cohort Studies, Comorbidity, Case-Control Studies, Disease Progression, Early Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
