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Cited by 389

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Carbon based nanomaterials for tissue engineering of bone: Building new bone on small black scaffolds: A review

Open access
Eivazzadeh-Keihan, Reza, Maleki, Ali, de la Guardia, Miguel, Bani, Milad Salimi, Chenab, Karim Khanmohammadi, Pashazadeh-Panahi, Paria, Baradaran, Behzad, Mokhtarzadeh, Ahad, Hamblin, Michael R.·2019·Journal of Advanced Research

Abstract

Tissue engineering is a rapidly-growing approach to replace and repair damaged and defective tissues in the human body. Every year, a large number of people require bone replacements for skeletal defects caused by accident or disease that cannot heal on their own. In the last decades, tissue engineering of bone has attracted much attention from biomedical scientists in academic and commercial laboratories. A vast range of biocompatible advanced materials has been used to form scaffolds upon which new bone can form. Carbon nanomaterial-based scaffolds are a key example, with the advantages of being biologically compatible, mechanically stable, and commercially available. They show remarkable ability to affect bone tissue regeneration, efficient cell proliferation and osteogenic differentiation. Basically, scaffolds are templates for growth, proliferation, regeneration, adhesion, and differentiation processes of bone stem cells that play a truly critical role in bone tissue engineering. The appropriate scaffold should supply a microenvironment for bone cells that is most similar to natural bone in the human body. A variety of carbon nanomaterials, such as graphene oxide (GO), carbon nanotubes (CNTs), fullerenes, carbon dots (CDs), nanodiamonds and their derivatives that are able to act as scaffolds for bone tissue engineering, are covered in this review. Broadly, the ability of the family of carbon nanomaterial-based scaffolds and their critical role in bone tissue engineering research are discussed. The significant stimulating effects on cell growth, low cytotoxicity, efficient nutrient delivery in the scaffold microenvironment, suitable functionalized chemical structures to facilitate cell-cell communication, and improvement in cell spreading are the main advantages of carbon nanomaterial-based scaffolds for bone tissue engineering.

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Metadata

Authors
Eivazzadeh-Keihan, R., Maleki, A., de la Guardia, M., Bani, M. S., Chenab, K. K., Pashazadeh-Panahi, P., Baradaran, B., Mokhtarzadeh, A., & Hamblin, M. R.
Venue
Journal of Advanced Research
Publisher
Elsevier BV
Published
2019-07
Volume
18
Pages
185-201
ISSN
  • 2090-1224 (ISSN-L)
  • 2090-1232
OpenAlex
W2934330486
Cited by
389
References
141
FWCI
18.24
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Carbon based nanomaterials for tissue engineering of bone: Building new bone on small black scaffolds: A review. https://app.cochat.ai/papers/10.1016/j.jare.2019.03.011
The paper
Eivazzadeh-Keihan, R., Maleki, A., de la Guardia, M., Bani, M. S., Chenab, K. K., Pashazadeh-Panahi, P., Baradaran, B., Mokhtarzadeh, A., & Hamblin, M. R. (2019). Carbon based nanomaterials for tissue engineering of bone: Building new bone on small black scaffolds: A review. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2019.03.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.