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Glycolysis: A multifaceted metabolic pathway and signaling hub
Open accessAbstract
Glycolysis is a highly conserved metabolic pathway responsible for the anaerobic production of adenosine triphosphate (ATP) from the breakdown of glucose molecules. While serving as a primary metabolic pathway in prokaryotes, glycolysis is also utilized by respiring eukaryotic cells, providing pyruvate to fuel oxidative metabolism. Furthermore, glycolysis is the primary source of ATP production in multiple cellular states (e.g., hypoxia) and is particularly important in maintaining bioenergetic homeostasis in the most abundant cell type in the human body, the erythrocyte. Beyond its role in ATP production, glycolysis also functions as a signaling hub, producing several metabolic intermediates which serve roles in both signaling and metabolic processes. These signals emanating from the glycolytic pathway can profoundly impact cell function, phenotype, and fate and have previously been overlooked. In this review, we will discuss the role of the glycolytic pathway as a source of signaling molecules in eukaryotic cells, emphasizing the newfound recognition of glycolysis' multifaceted nature and its importance in maintaining cellular homeostasis, beyond its traditional role in ATP synthesis.
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“Even under hypoxic conditions, glycolysis remains the predominant pathway for ATP generation in tumor cells (11).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [11]
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Metadata
- Authors
- Kierans, S. J., & Taylor, C. T.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Taylor, Cormac T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2024-11
- Volume
- 300
- Issue
- 11
- Pages
- 107906
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC11605472
- OpenAlex
- W4403659524
- Cited by
- 198
- References
- 182
- Citations by year
- 2026: 125 · 2025: 72 · 2024: 1
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Taighde Éireann – Research Ireland (22/FFP-A/10523)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- glycolysis, metabolic intermediates, ATP production, erythrocytes, hypoxia, bioenergetic homeostasis, pyruvate, eukaryotic cells, cellular homeostasis, cell fate
- MeSH terms
- Adenosine Triphosphate, Animals, Energy Metabolism, Glycolysis, Homeostasis, Humans, Signal Transduction, Metabolic Networks and Pathways
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