Taylor, Cormac T.

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature

Immune Response and InflammationImmune cells in cancer

Cited by 4,176

Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function

Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,716

Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology

Kierans, S. J., & Taylor, C. T. (2021) · The Journal of Physiology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,015

Selective Activation of Inflammatory Pathways by Intermittent Hypoxia in Obstructive Sleep Apnea Syndrome

Ryan, S., Taylor, C. T., & McNicholas, W. T. (2005) · Circulation

Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleep

Cited by 970

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 788

Regulation of Immunity and Inflammation by Hypoxia in Immunological Niches

Taylor, C. T., & Colgan, S. P. (2017) · Nature reviews. Immunology

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 713

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 704

The effect of HIF on metabolism and immunity

Taylor, C. T., & Scholz, C. C. (2022) · Nature Reviews Nephrology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 517

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology

Inflammatory Bowel DiseaseGut microbiota and health

Cited by 461

Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

Furuta, G. T., Turner, J. R., Taylor, C. T., Hershberg, R. M., Comerford, K., Narravula, S., Podolsky, D. K., & Colgan, S. P. (2001) · The Journal of Experimental Medicine

Barrier Structure and Function StudiesDigestive system and related health

Cited by 449

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology

Inflammatory Bowel DiseaseMicroscopic Colitis

Cited by 407

Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation

Taylor, C. T. (2008) · The Journal of Physiology

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 354

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine

Inflammatory Bowel DiseaseCancer, Hypoxia, and Metabolism

Cited by 313

Mitochondria and cellular oxygen sensing in the HIF pathway

Taylor, C. T. (2008) · Biochemical Journal

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 298

A mitochondria-targeted S -nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Prime, T. A., Blaikie, F. H., Evans, C., Nadtochiy, S. M., James, A. M., Dahm, C. C., Vitturi, D. A., Patel, R. P., Hiley, C. R., Abakumova, I., et al. (2009) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 222

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia

Taylor, C. T., & Moncada, S. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 220

Glycolysis: A multifaceted metabolic pathway and signaling hub

Kierans, S. J., & Taylor, C. T. (2024) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 198

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Walmsley, S. R., Chilvers, E. R., Thompson, A. A., Vaughan, K., Marriott, H. M., Parker, L. C., Shaw, G., Parmar, S., Schneider, M., Sabroe, I., et al. (2011) · Journal of Clinical Investigation

Cell death mechanisms and regulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 191

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 189

Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor α

Taylor, C. T., Dzus, A. L., & Colgan, S. P. (1998) · Gastroenterology

Gastrointestinal motility and disordersInflammatory Bowel Disease

Cited by 188

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Scholz, C. C., Cavadas, M. A. S., Tambuwala, M. M., Hams, E., Rodríguez, J., Kriegsheim, A. V., Cotter, P., Bruning, U., Fallon, P. G., Cheong, A., et al. (2013) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 186

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia

Comerford, K. M., Leonard, M. O., Karhausen, J., Carey, R., Colgan, S. P., & Taylor, C. T. (2003) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 185

The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, C. T., & Cummins, E. P. (2009) · Annals of the New York Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 175

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

Taylor, C. T., & McElwain, J. C. (2010) · Physiology

Cancer, Hypoxia, and MetabolismHemoglobin structure and function

Cited by 135