Glycolysis: A multifaceted metabolic pathway and signaling hub

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Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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Sirtuins as regulators of metabolism and healthspan

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Inhibitory effect of tumor cell-derived lactic acid on human T cells

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Glucose feeds the TCA cycle via circulating lactate

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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Physiology and Pathophysiology of Purinergic Neurotransmission

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NAD+ and sirtuins in aging and disease

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

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(ADP-ribose)n participates in DNA excision repair

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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

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Complexes of sequential metabolic enzymes

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Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology

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ATP as a biological hydrotrope

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Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

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The sirtuin family in health and disease

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Structure of mammalian AMPK and its regulation by ADP

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ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

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Cell–cell and intracellular lactate shuttles

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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

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The biochemistry of sirtuins

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

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Multifaceted roles of glycolytic enzymes

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

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Calorie restriction extends yeast life span by lowering the level of NADH

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Ca 2+ -Induced Ca 2+ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose

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Regulation of Corepressor Function by Nuclear NADH

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Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

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AMPK is a direct adenylate charge-regulated protein kinase

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Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, gpr81

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Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei : The glycosome

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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

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Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle

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Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

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Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

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NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1

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Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

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Blood lactate is an important energy source for the human brain.

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Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase

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TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

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Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia

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The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

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Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane

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Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

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Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments.

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Enzymes of Glycolysis Are Functionally Associated with the Mitochondrion in Arabidopsis Cells

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Lactate Limits T Cell Proliferation via the NAD(H) Redox State

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Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

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Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

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Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

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Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

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Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

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Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

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β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

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Lactic Acid: No Longer an Inert and End-Product of Glycolysis

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Lactate metabolism is associated with mammalian mitochondria

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The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

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Role of GPR81 in lactate-mediated reduction of adipose lipolysis

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Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

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Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer

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Active muscle and whole body lactate kinetics after endurance training in men

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Glycolytic Enzymes Associate Dynamically with Mitochondria in Response to Respiratory Demand and Support Substrate Channeling

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Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

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Glycolytic enzymes localize to synapses under energy stress to support synaptic function

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The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

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The Hexosamine Biosynthesis Pathway: Regulation and Function

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Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

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Bioluminescence detection of ATP release mechanisms in epithelia

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Dihydroxyacetone phosphate signals glucose availability to mTORC1

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The Spatial Organization of Metabolism Within the Plant Cell

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Extracellular ATP Induces a Distorted Maturation of Dendritic Cells and Inhibits Their Capacity to Initiate Th1 Responses

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