Damage-induced hydrolyses modelling of biodegradable polymers for tendons and ligaments repair
Open accessAbstract
The use of biodegradable synthetic grafts to repair injured ligaments may overcome the disadvantages of other solutions. Apart from biological compatibility, these devices shall also be functionally compatible and temporarily displayed, during the healing process, adequate mechanical support. Laxity of these devices is an important concern. This can cause failure since it may result in joint instability. Laxity results from a progressive accumulation of plastic strain during the cyclic loading. The functional compatibility of a biodegradable synthetic graft and, therefore, the global mechanical properties of the scaffold during degradation, can be optimised using computer-aiding and numerical tools. Therefore, in this work, the ability of numerical tools to predict the mechanical behaviour of the device during its degradation is discussed. Computational approaches based on elastoplastic and viscoplastic constitutive models are also presented. These models enable to simulate the plastic strain accumulation. These computational approaches, where the material model parameters depend on the hydrolytic degradation damage, are calibrated using experimental data measured from biodegradable suture fibres at different degradation steps. Due to durability requirements the selected materials are polydioxone (PDO) and polylactic acid and poly-caprolactone blend (PLA-PCL). Computational approaches investigated are able to predict well the experimental results for both materials, in full strain range until rupture and for different degradation steps. These approaches can be further used in more complex fibrous structures, to predict its global mechanical behaviour during degradation process.
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PLA is a bioabsorbable material and is widely used in orthopedic surgery.
“In addition to being used in sutures, PLA is a bioabsorbable material and is widely used in orthopedic surgery [32,73].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [73]
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- Authors
- Vieira, A. C., Guedes, R. M., & Tita, V.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade do Porto (PT)
- Corresponding author
- Vieira, André C.
- Venue
- Journal of Biomechanics
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 48
- Issue
- 12
- Pages
- 3478-3485
- ISSN
- 0021-9290 (ISSN-L)
- OpenAlex
- W2101376287
- Cited by
- 20
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 393 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Journal of Biomechanics (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- CAPES (022/2012)
- CNPq
- USP (11.1.31369.1.7)
- UP
- University of Porto (Portugal)
- University of São Paulo (Brazil)
- FCT (Portuguese Science and Technology Foundation) (PTDC//114808/2009)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- biodegradable polymers, hydrolytic degradation, ligament repair, tendon repair, polylactic acid, PLA/PCL blends, viscoplastic constitutive model, elastoplastic model, plastic strain accumulation, cyclic loading, graft laxity
- MeSH terms
- Biocompatible Materials, Hydrolysis, Ligaments, Models, Biological, Polymers, Sutures, Tendon Injuries, Tendons, Wound Healing, Mechanical Phenomena
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