Quality of life in patients with Cystic Fibrosis: association with anxiety and depression
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Background Few studies of patients with CF have looked at the association between patient reported Health-Related Quality of Life (HRQoL) and anxiety and depression. This study investigated whether CF patients with symptoms of anxiety or depression reported lower Health-Related Quality of Life (HRQoL) scores.Methods 57 adult CF patients completed the Hospital Anxiety and Depression Scale (HADS) and the Cystic Fibrosis Questionnaire, a CF-specific measure of HRQoL. Analyses of variance with lung function as a covariate were used to investigate differences in HRQoL between groups of patients with and without symptoms of anxiety and depression.Results Mean age was 26.7 years (SD 8.1), mean FEV1 %predicted was 65.09 (SD 22.18). Anxiety and depression scores were low and similar to normative scores. After controlling for lung function, patients with symptoms of anxiety reported lower on vitality, emotional functioning, social, treatment burden, health perceptions and respiratory symptoms. Those with depressive symptoms reported lower HRQoL scores for emotional functioning, eating disturbances and body image.Conclusions Preliminary evidence was found of the role of anxiety and depression in different areas of quality of life in CF, which may help in the development of appropriate medical and psychosocial treatment programs.
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For adults with cystic fibrosis, rates of anxiety have ranged from 30% to 33%.
“rates of anxiety from 30% to 33%.”
From Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries (2014) · cites this paper as [8]
Section 3.2 (HADS) reports that 18 of 57 adult patients with cystic fibrosis (30%) scored in the borderline/clinical anxiety category. Our copy does not report a 33% rate, so it supports the lower end of the stated range but not the upper end. (LLM, conf=0.88)
Experimental — accuracy not yet measuredFor adults with cystic fibrosis, rates of depression have ranged from 13% to 30%.
“For adults with CF, rates of depression have ranged from 13% to 30%”
From Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries (2014) · cites this paper as [8]
Section 3.2 (HADS; page not provided) reports that 13% of the adult CF patients scored in the borderline/clinical category for depression. Its 30% figure refers to anxiety, not depression, so the claimed upper end of the depression range is unsupported. (LLM, conf=0.91)
Experimental — accuracy not yet measuredComorbid depressive and anxiety symptoms can impact AYA's quality of life, treatment adherence, and outcomes.
“Comorbid depressive and anxiety symptoms can additionally impact AYA's quality of life, treatment adherence, and outcomes (Havermans et al., 2008) as well as negatively impact the long-term outcomes of the disease (Fidika et al., 2014).”
From Involving patients' perspective in the development of an internet- and mobile-based CBT intervention for adolescents with chronic medical conditions: Findings from a qualitative study (2021) · cites this paper as Havermans et al., 2008
The Discussion reports that adult CF patients with anxiety or depressive symptoms scored lower on aspects of health-related quality of life, but says the direction of that relationship is unknown. It discusses non-compliance and deteriorating health as possibilities, and cites adherence and outcome risks in other chronic conditions; it does not establish those effects in its CF patients or specifically in adolescents and young adults. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAnxiety and depressive symptoms are associated with decreased quality of life in individuals with cystic fibrosis.
“quality of life [4]”
From ACT with CF: A telehealth and in-person feasibility study to address anxiety and depressive symptoms among people with cystic fibrosis (2021) · cites this paper as [4]
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Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
The Hospital Anxiety And Depression Scale.
(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-29 · Cited by 2,391 · see citing works
SPINHOVEN, P., ORMEL, J., SLOEKERS, P. P. A., KEMPEN, G. I. J. M., SPECKENS, A. E. M., & HEMERT, A. M. V. (1997) · Psychological Medicine · doi:10.1017/s0033291796004382 · Cited by 2,158 · see citing works
Depressive Symptoms and Health-Related Quality of Life
Ruo, B., Rumsfeld, J. S., Hlatky, M. A., Liu, H., Browner, W. S., & Whooley, M. A. (2003) · JAMA · doi:10.1001/jama.290.2.215 · Cited by 742 · see citing works
Development and Validation of the Cystic Fibrosis Questionnaire in the United States
Quittner, A. L., Buu, A., Messer, M. A., Modi, A. C., & Watrous, M. L. (2005) · CHEST Journal · doi:10.1378/chest.128.4.2347 · Cited by 510 · see citing works
Gee, L. (2000) · Thorax · doi:10.1136/thorax.55.11.946 · Cited by 272 · see citing works
Jörngården, A., Wettergen, L., & von Essén, L. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-91 · Cited by 209 · see citing works
Clarke, S.-A., & Eiser, C. (2004) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-2-66 · Cited by 205 · see citing works
Riekert, K. A., Bartlett, S. J., Boyle, M. P., Krishnan, J. A., & Rand, C. S. (2007) · Chest · doi:10.1378/chest.06-2474 · Cited by 197 · see citing works
Gee, L., Abbott, J., Conway, S. P., Etherington, C., & Webb, A. K. (2003) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(03)00093-6 · Cited by 153 · see citing works
Staab, D., Wenninger, K., Gebert, N., Rupprath, K., Bisson, S., Trettin, M., Paul, K.-D., Keller, K., & Wahn, U. (1998) · Thorax · doi:10.1136/thx.53.9.727 · Cited by 108 · see citing works
The psychosocial and psychiatric side of cystic fibrosis in adolescents and adults
Pfeffer, P., Pfeffer, J. M., & Hodson, M. E. (2003) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(03)00020-1 · Cited by 103 · see citing works
Gender differences in health-related quality of life of adolescents with cystic fibrosis
Arrington‐Sanders, R., Yi, M., Tsevat, J., Wilmott, R. W., Mrus, J. M., & Britto, M. T. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-5 · Cited by 95 · see citing works
Associations between clinical variables and quality of life in adults with cystic fibrosis
Gee, L., Abbott, J., Hart, A., Conway, S. P., Etherington, C., & Webb, A. K. (2005) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2004.12.005 · Cited by 85 · see citing works
Psychological Functioning of Adults With Cystic Fibrosis
Anderson, D. L., Flume, P. A., & Hardy, K. K. (2001) · CHEST Journal · doi:10.1378/chest.119.4.1079 · Cited by 65 · see citing works
Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults
Klijn, P. H. C., van Stel, H. F., Quittner, A. L., van der Net, J. J., Doeleman, W. R., van der Schans, C. P., & van der Ent, C. K. (2004) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2003.12.006 · Cited by 63 · see citing works
Wenninger, K., Aussage, P., Wahn, U., & Staab, D. (2003) · Quality of Life Research · doi:10.1023/a:1022011704399 · Cited by 60 · see citing works
Questions on Life Satisfaction for Adolescents and Adults With Cystic Fibrosis
Goldbeck, L., Schmitz, T. G., Henrich, G., & Herschbach, P. (2003) · CHEST Journal · doi:10.1378/chest.123.1.42 · Cited by 53 · see citing works
Abbott, J., & Hart, A. (2005) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-3-19 · Cited by 51 · see citing works
Special Considerations for Patients With Cystic Fibrosis Undergoing Lung Transplantation
Hadjiliadis, D. (2007) · CHEST Journal · doi:10.1378/chest.06-1163 · Cited by 51 · see citing works
Weiner, J., Toy, E. L., Sacco, P., & Duh, M. S. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.5.751 · Cited by 41 · see citing works
Alters- und geschlechtsbezogene Betrachtung der Lebensqualität bei Mukoviszidose
Schmitz, T. G., Henrich, G., & Goldbeck, L. (2006) · Klinische Pädiatrie · doi:10.1055/s-2004-832485 · Cited by 11 · see citing works
Depression and Health-Related Quality of Life—Reply
Gandjour, A. (2003) · JAMA · doi:10.1001/jama.290.18.2404-b · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Schmitz TG, Henrich G, Goldbeck L. Quality of life with cystic fibrosis- aspects of age and gender. Klin Padiatr Jan-Feb 2006;218(1):7-12.
Cited by
Sorted by citations
Quittner, A. L., Goldbeck, L., Abbott, J., Duff, A., Lambrecht, P., Solé, A., Tibosch, M. M., Bergsten Brucefors, A., Yüksel, H., Catastini, P., et al. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205983 · Cited by 524 · see citing works
Quittner, A. L., Abbott, J., Georgiopoulos, A. M., Goldbeck, L., Smith, B., Hempstead, S. E., Marshall, B., Sabadosa, K. A., & Elborn, S. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-207488 · Cited by 450 · see citing works
Depression, illness severity, and healthcare utilization in cystic fibrosis
Snell, C., Fernandes, S., Bujoreanu, I. S., & Garcia, G. (2014) · Pediatric Pulmonology · doi:10.1002/ppul.22990 · Cited by 108 · see citing works
Relationship between anxiety, depression, and quality of life in adult patients with cystic fibrosis
Yohannes, A. M., Willgoss, T. G., Fatoye, F. A., Dip, M. D., & Webb, K. (2012) · Respiratory Care · doi:10.4187/respcare.01328 · Cited by 96 · see citing works
Prevalence of symptoms of anxiety and depression in German patients with cystic fibrosis
Goldbeck, L., Besier, T., Hinz, A., Singer, S., & Quittner, A. L. (2010) · Chest · doi:10.1378/chest.09-2940 · Cited by 89 · see citing works
Acceptance and well-being in adolescents and young adults with cystic fibrosis: A prospective study
Casier, A., Goubert, L., Theunis, M., Huse, D., De Baets, F., Matthys, D., & Crombez, G. (2011) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq111 · Cited by 60 · see citing works
Quon, B. S., Bentham, W. D., Unutzer, J., Chan, Y.-F., Goss, C. H., & Aitken, M. L. (2015) · Psychosomatics · doi:10.1016/j.psym.2014.05.017 · Cited by 53 · see citing works
Catastini, P., Di Marco, S., Furriolo, M., Genovese, C., Grande, A., Iacinti, E., Iusco, D. R., Nobili, R. M. V., Pescini, R., Ragni, R., et al. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23566 · Cited by 36 · see citing works
O'Hayer, C. V., O'Loughlin, C. M., Nurse, C. N., Smith, P. J., & Stephen, M. J. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.11.013 · Cited by 34 · see citing works
Geirhos, A., Lunkenheimer, F., Holl, R. W., Minden, K., Schmitt, A., Temming, S., Baumeister, H., & Domhardt, M. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100383 · Cited by 23 · see citing works
Duff, A. J. A. (2015) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2015.07.006 · Cited by 17 · see citing works
Sherman, A. C., Simonton-Atchley, S., O’Brien, C. E., Campbell, D., Reddy, R. M., Guinee, B., Wagner, L. D., & Anderson, P. J. (2021) · Journal of Religion and Health · doi:10.1007/s10943-021-01185-x · Cited by 15 · see citing works
O'Hayer, C. V., Smith, P. J., Drescher, C. F., Bruschwein, H., Nurse, C. N., Kushner, H. M., Ingle, K., Stephen, M. J., & Hoag, J. B. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.11.011 · Cited by 12 · see citing works
- Authors
- Havermans, T., Colpaert, K., & Dupont, L. J.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Havermans, Trudy
- ORCID
- Dupont, Lieven J.
- Venue
- Journal of Cystic Fibrosis
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 7
- Issue
- 6
- Pages
- 581-584
- ISSN
- 1569-1993 (ISSN-L)
- OpenAlex
- W1966880343
- Cited by
- 124
- References
- 24
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 6
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cystic Fibrosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- health-related quality of life, anxiety, depression, depressive symptoms, anxiety symptoms, Hospital Anxiety and Depression Scale, lung function, emotional functioning, body image, disordered eating, psychosocial interventions
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Cross-Sectional Studies, Cystic Fibrosis, Depressive Disorder, Female, Forced Expiratory Volume, Health Status, Humans, Male, Quality of Life, Risk Factors, Cohort Studies, Cost of Illness, Young Adult
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