Depression in cystic fibrosis; Implications of The International Depression/Anxiety Epidemiological Study (TIDES) in cystic fibrosis
Abstract
Children and adults with chronic diseases, as well as their parents, are at increased risk for depression. Where people with CF do exhibit psychological distress it is linked to poorer adherence and pulmonary function, increased hospitalisations and healthcare costs and decreased quality of life. The International Depression Epidemiological Study (TIDES) evaluated depression and anxiety in CF patients and parent caregivers across eight European countries and the USA. Two national and one international data sets have been published. This paper summarises the findings, offers explanations for differences in results, and outlines the clinical implications with consideration given to if and how recommendations could be integrated into managing CF in the UK.
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Anxiety and depressive symptoms are associated with decreased treatment adherence in individuals with cystic fibrosis.
“treatment adherence [2]”
From ACT with CF: A telehealth and in-person feasibility study to address anxiety and depressive symptoms among people with cystic fibrosis (2021) · cites this paper as [2]
Cites
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
Validity of the brief patient health questionnaire mood scale (PHQ-9) in the general population
Martin, A., Rief, W., Klaiberg, A., & Braehler, E. (2006) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.07.003 · Cited by 1,379 · see citing works
Pignone, M. P., Gaynes, B. N., Rushton, J. L., Burchell, C. M., Orleans, C. T., Mulrow, C. D., & Lohr, K. N. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-10-200205210-00013 · Cited by 1,086 · see citing works
Normative data for the HADS from a large non-clinical sample
Crawford, J. R., Henry, J. D., Crombie, C., & Taylor, E. P. (2001) · British Journal of Clinical Psychology · doi:10.1348/014466501163904 · Cited by 815 · cited 1× · see citing works
“Raw HADS data from the UK group was converted to centile scores to compare elevated symptoms with a UK community sample using the same measure [16,17].”
MethodCystic fibrosis mortality and survival in the UK: 1947–2003
DODGE, J. A., Lewis, P. A., Stanton, M., & Wilsher, J. (2006) · European Respiratory Journal · doi:10.1183/09031936.00099506 · Cited by 627 · see citing works
Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care
Cameron, I. M., Crawford, J. R., Lawton, K., & Reid, I. C. (2008) · British Journal of General Practice · doi:10.3399/bjgp08x263794 · Cited by 590 · see citing works
European cystic fibrosis society standards of care: best practice guidelines
Smyth, A. R., Bell, S. C., Bojcin, S., Bryon, M., Duff, A., Flume, P., Kashirskaya, N., Munck, A., Ratjen, F., Schwarzenberg, S. J., et al. (2014) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2014.03.010 · Cited by 582 · see citing works
Quittner, A. L., Goldbeck, L., Abbott, J., Duff, A., Lambrecht, P., Solé, A., Tibosch, M. M., Bergsten Brucefors, A., Yüksel, H., Catastini, P., et al. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205983 · Cited by 524 · cited 7× · see citing works
“if a parent was also elevated [15].”
BackgroundInfluentialPinquart, M., & Shen, Y. (2011) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq104 · Cited by 506 · see citing works
High treatment burden in adults with cystic fibrosis: challenges to disease self-management
Sawicki, G. S., Sellers, D. E., & Robinson, W. M. (2009) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2008.09.007 · Cited by 498 · see citing works
Screening and case-finding instruments for depression: a meta-analysis
Gilbody, S., Sheldon, T., & House, A. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070281 · Cited by 443 · see citing works
Riekert, K. A., Bartlett, S. J., Boyle, M. P., Krishnan, J. A., & Rand, C. S. (2007) · Chest · doi:10.1378/chest.06-2474 · Cited by 197 · see citing works
Smith, B. A., Modi, A. C., Quittner, A. L., & Wood, B. L. (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21238 · Cited by 185 · see citing works
Crawford, J. R., Garthwaite, P. H., Lawrie, C. J., Henry, J. D., MacDonald, M. A., Sutherland, J., & Sinha, P. (2008) · British Journal of Clinical Psychology · doi:10.1348/014466508x377757 · Cited by 129 · see citing works
Quality of life in patients with Cystic Fibrosis: association with anxiety and depression
Havermans, T., Colpaert, K., & Dupont, L. J. (2008) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2008.05.010 · Cited by 124 · see citing works
Cameron, I. M., Cardy, A., Crawford, J. R., du Toit, S. W., Hay, S., Lawton, K., Mitchell, K., Sharma, S., Shivaprasad, S., Winning, S., et al. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x583209 · Cited by 109 · see citing works
Depression, illness severity, and healthcare utilization in cystic fibrosis
Snell, C., Fernandes, S., Bujoreanu, I. S., & Garcia, G. (2014) · Pediatric Pulmonology · doi:10.1002/ppul.22990 · Cited by 108 · see citing works
Relationship between anxiety, depression, and quality of life in adult patients with cystic fibrosis
Yohannes, A. M., Willgoss, T. G., Fatoye, F. A., Dip, M. D., & Webb, K. (2012) · Respiratory Care · doi:10.4187/respcare.01328 · Cited by 96 · see citing works
Prevalence of symptoms of anxiety and depression in German patients with cystic fibrosis
Goldbeck, L., Besier, T., Hinz, A., Singer, S., & Quittner, A. L. (2010) · Chest · doi:10.1378/chest.09-2940 · Cited by 89 · see citing works
Medication beliefs mediate between depressive symptoms and medication adherence in cystic fibrosis.
Hilliard, M. E., Eakin, M. N., Borrelli, B., Green, A., & Riekert, K. A. (2014) · Health Psychology · doi:10.1037/hea0000136 · Cited by 77 · see citing works
Abbott, J., Elborn, J. S., Georgiopoulos, A. M., Goldbeck, L., Marshall, B. C., Sabadosa, K. A., Smith, B. A., & Quittner, A. L. (2015) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2014.12.015 · Cited by 56 · see citing works
Quon, B. S., Bentham, W. D., Unutzer, J., Chan, Y.-F., Goss, C. H., & Aitken, M. L. (2015) · Psychosomatics · doi:10.1016/j.psym.2014.05.017 · Cited by 53 · see citing works
Duff, A. J. A., Abbott, J., Cowperthwaite, C., Sumner, C., Hurley, M. A., & Quittner, A. L. (2014) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2014.02.010 · Cited by 51 · see citing works
Screening for depression in a single CF Centre
Latchford, G., & Duff, A. J. A. (2013) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2013.04.002 · Cited by 31 · see citing works
Fauman, K. R., Pituch, K. J., Han, Y. Y., Niedner, M. F., Reske, J., & LeVine, A. M. (2011) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909111403465 · Cited by 28 · see citing works
The International Depression Epidemiological Study (TIDES): unfinished business?
Webb, A. K., & Bryon, M. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-206200 · Cited by 8 · see citing works
Letter to the editor: authors’ response
Quittner, A. L., Barker, D., Goldbeck, L., Duff, A. J. A., & Abbott, J. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206708 · Cited by 3 · see citing works
Duff, A. J. A., Bowmer, G., Waldron, R., Cammidge, S., Peckham, D. G., & Latchford, G. J. (2015) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(15)30432-x · Cited by 1 · see citing works
Response to: ‘On the TIDES study’, by Quittneret al
Bryon, M., & Webb, A. K. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-206787 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Therapeutic challenges posed by critical drug–drug interactions in cystic fibrosis
Jordan, C. L., Noah, T. L., & Henry, M. M. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23505 · Cited by 65 · see citing works
O'Hayer, C. V., O'Loughlin, C. M., Nurse, C. N., Smith, P. J., & Stephen, M. J. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.11.013 · Cited by 34 · see citing works
O'Hayer, C. V., Smith, P. J., Drescher, C. F., Bruschwein, H., Nurse, C. N., Kushner, H. M., Ingle, K., Stephen, M. J., & Hoag, J. B. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.11.011 · Cited by 12 · see citing works
The prevalence of anxiety in respiratory and sleep diseases: A systematic review and meta-analysis
Storer, B., Holden, M., Kershaw, K. A., Braund, T. A., Chakouch, C., Coleshill, M. J., Haffar, S., Harvey, S. B., Sicouri, G., Newby, J. M., et al. (2024) · Respiratory Medicine · doi:10.1016/j.rmed.2024.107677 · Cited by 11 · see citing works
Aguiar, K. C. A., Marson, F. A. L., Gomez, C. C. S., Pereira, M. C., Paschoal, I. A., Ribeiro, A. F., & Ribeiro, J. D. (2017) · Revista Portuguesa de Pneumologia · doi:10.1016/j.rppnen.2017.02.009 · Cited by 10 · see citing works
Russell, J. K., Strodl, E. S., Connolly, J., & Kavanagh, D. J. (2019) · Journal of Health Psychology · doi:10.1177/1359105319876336 · Cited by 8 · see citing works
Russell, J. K., Strodl, E. S., & Kavanagh, D. J. (2021) · International Journal of Social Robotics · doi:10.1007/s12369-021-00765-x · Cited by 6 · see citing works
Mental Health in Cystic Fibrosis
Behrhorst, K. L., Everhart, R. S., & Schechter, M. S. (2020) · Respiratory medicine · doi:10.1007/978-3-030-42382-7_21 · Cited by 4 · see citing works
Clinician perspectives on barriers and solutions to symptom management in cystic fibrosis
Smirnova, N., Trandel, E. T., Dubin, E. H., Lowers, J., Dellon, E. P., Hempstead, S. E., Faro, A., Tallarico, E., & Kavalieratos, D. (2023) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2023.05.016 · Cited by 4 · see citing works
Wybrane wskaźniki statusu socjoekonomicznego rodziców dzieci z mukowiscydozą
Zubrzycka, R. A. (2018) · Lubelski Rocznik Pedagogiczny · doi:10.17951/lrp.2017.36.2.197 · Cited by 1 · see citing works
Behavioral Health Screening in Military Cystic Fibrosis Centers: A Survey.
Rutledge, C., Gould, C., Lee, P. C., Sowden, W., Lustik, M., & Egan, K. (2022) · Military Medicine · doi:10.1093/milmed/usac161 · Cited by 2 · see citing works
O’Hayer, C. V., Smith, P. J., Drescher, C. F., Bruschwein, H. M., Nurse, C. N., Kushner, H. M., Ingle, K., Stephen, M. J., & Hoag, J. B. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4854423 · Cited by 1 · see citing works
Zubrzycka, R. A. (2020) · Man – Disability – Society · doi:10.5604/01.3001.0014.1675
Russell, J. K. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.207787
Ferez, S., Silvestri, L., Issanchou, D., Boucher, N., & Fougeyrollas, P. (2023) · Alter · doi:10.4000/9ifo
Primary Ciliary Dyskinesia: A Suggested Pathway to Transition From Pediatric to Adult Care
Castro, A. D., Collins, M. S., Jain, R., Walsh, J. B., Alba-Suarez, J., & Rivera-Sanchez, Y. M. (2026) · Pediatric Pulmonology · doi:10.1002/ppul.71780
- Authors
- Duff, A. J. A.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- Duff, Alistair J.A.
- ORCID
- Duff, Alistair J.A.
- Venue
- Paediatric Respiratory Reviews
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 16
- Pages
- 2-5
- ISSN
- 1526-0542 (ISSN-L)
- OpenAlex
- W1752580571
- Cited by
- 17
- References
- 30
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Paediatric Respiratory Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- cystic fibrosis, depression, anxiety, psychological distress, caregiver depression, medication adherence, lung function, hospitalization, health care costs, quality of life, chronic disease, depression screening
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Child, Cystic Fibrosis, Depressive Disorder, Female, Humans, Male, Mass Screening, Parents, Epidemiologic Studies, Caregivers
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