Physical activity and incidence of heart failure in postmenopausal women
Open accessAbstract
Objectives This study prospectively examined physical activity levels and the incidence of heart failure (HF) in 137,303 women, ages 50 to 79 years, and examined a subset of 35,272 women who, it was determined, had HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF).Background The role of physical activity in HF risk among older women is unclear, particularly for incidence of HFpEF or HFrEF.Methods Women were free of HF and reported ability to walk at least 1 block without assistance at baseline. Recreational physical activity was self-reported. The study documented 2,523 cases of total HF, and 451 and 734 cases of HFrEF and HFpEF, respectively, during a mean 14-year follow-up.Results After controlling for age, race, education, income, smoking, alcohol, hormone therapy, and hysterectomy status, compared with women who reported no physical activity (reference group), inverse associations were observed across incremental tertiles of total physical activity for overall HF (hazard ratio [HR]: Tertile 1 = 0.89, Tertile 2 = 0.74, Tertile 3 = 0.65; trend p < 0.001), HFpEF (HR: 0.93, 0.70, 0.68; p < 0.001), and HFrEF (HR: 0.81, 0.59, 0.68; p = 0.01). Additional controlling for potential mediating factors included attenuated time-varying coronary heart disease (CHD) (nonfatal myocardial infarction, coronary revascularization) diagnosis but did not eliminate the inverse associations. Walking, the most common form of physical activity in older women, was also inversely associated with HF risks (overall: 1.00, 0.98, 0.93, 0.72; p < 0.001; HFpEF: 1.00, 0.98, 0.87, 0.67; p < 0.001; HFrEF: 1.00, 0.75, 0.78, 0.67; p = 0.01). Associations between total physical activity and HF were consistent across subgroups, defined by age, body mass index, diabetes, hypertension, physical function, and CHD diagnosis. Analysis of physical activity as a time-varying exposure yielded findings comparable to those of baseline physical activity.Conclusions Higher levels of recreational physical activity, including walking, are associated with significantly reduced HF risk in community-dwelling older women.
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MET-minutes and MET-hours are often used to assess PA dose with various health outcomes.
“MET-minutes and MET-hours are often used to assess PA dose with various health outcomes.25”
From 2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities (2024) · cites this paper as [25]
The Methods (Physical Activity Assessment; page unavailable) use MET-hours/week to measure physical activity, and the Results relate that measure to heart-failure outcomes. The paper does not establish that MET-minutes are often used or that these measures are used across various health outcomes. (LLM, conf=0.86)
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2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities
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- Authors
- LaMonte, M. J., Manson, J. E., Chomistek, A. K., Larson, J. C., Lewis, C. E., Bea, J. W., Johnson, K. C., Li, W., Klein, L., LaCroix, A. Z., Stefanick, M. L., Wactawski-Wende, J., & Eaton, C. B.
- Affiliations
- University at Buffalo, State University of New York (US)
- Brigham and Women's Hospital (US)
- Indiana University Bloomington (US)
- Fred Hutch Cancer Center (US)
- University of Alabama at Birmingham (US)
- University of Arizona Cancer Center (US)
- University of Tennessee Health Science Center (US)
- University of Massachusetts Chan Medical School (US)
- University of San Francisco (US)
- University of California San Diego (US)
- Stanford Medicine (US)
- Brown University (US)
- Corresponding author
- LaMonte, Michael J.
- ORCID
- Venue
- JACC: Heart Failure
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 6
- Issue
- 12
- Pages
- 983-995
- ISSN
- 2213-1779 (ISSN-L)
- PMC
- PMC6275092
- OpenAlex
- W2889780624
- Cited by
- 49
- References
- 45
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 14 · 2019: 3 · 2018: 1
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- JACC Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HHSN268201600018C, HHSN268201600004C, HHSN268201600001C, HHSN268201600003C, HHSN268201600002C)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- physical activity, heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, postmenopausal women, older women, leisure-time physical activity, walking, heart failure incidence, coronary artery disease, hormone therapy, hysterectomy, cardiovascular risk factors, cardiovascular disease prevention, sex differences in cardiovascular disease, cardiovascular hospitalization
- MeSH terms
- Aged, Female, Heart Failure, Humans, Middle Aged, Prospective Studies, Stroke Volume, Exercise, Postmenopause
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