Cited by 118Diabetes and associated disordersPancreatic function and diabetesDiabetes Management and Research

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Understanding Type 1 Diabetes: Etiology and Models

Acharjee, Satarupa, Ghosh, Bijaya, Al-Dhubiab, Bandar E., Nair, Anroop B.·2013·Canadian Journal of Diabetes

DOI 10.1016/j.jcjd.2013.05.001

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Abstract

Type 1 diabetes is a complex disease involving a combination of factors, such as genetic susceptibility, immunologic dysregulation and exposure to environmental triggers. Animal models serve an important function both in elucidating the pathophysiology and preliminary screening of antidiabetic molecules. Hence, the development of models for type 1 diabetes can be broadly divided into 3 categories, namely: identification of spontaneously developing type 1 diabetes mellitus strains, creating diabetes-prone species through gene transfer techniques and forced destruction of islet cells through chemical or surgical means. This review discusses the models used to study type 1 diabetes with special emphasis on genetics.

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Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
The use of animal models in diabetes research
King, A. J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01911.x · Cited by 1,303
Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice
Ohashi, P. S., Oehen, S., Buerki, K., Pircher, H., Ohashi, C. T., Odermatt, B., MALISSEN, B., Zinkernagel, R. M., & Hengartner, H. (1991) · Cell · doi:10.1016/0092-8674(91)90164-t · Cited by 1,175
Animal models of diabetes mellitus
Rees, A., & Alcolado, J. C. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01499.x · Cited by 753
DRUGS PRODUCING DIABETES THROUGH DAMAGE OF THE INSULIN SECRETING CELLS
Rerup, C. (1970) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06885-1 · Cited by 731
The rise of childhood type 1 diabetes in the 20th century.
Gale, E. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3353 · Cited by 673
The NOD mouse model of type 1 diabetes: As good as it gets?
Atkinson, M. A., & Leiter, E. H. (1999) · Nature Medicine · doi:10.1038/9442 · Cited by 588
Genetics of type 1A diabetes
Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510

Show all 52 references

Research works printed but not linked: 1

Chatzigeorgiou, 2009, Animal models of diabetes: a synopsis, In Vivo, 23, 245

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Authors: Acharjee, S., Ghosh, B., Al-Dhubiab, B. E., & Nair, A. B.
Affiliations: King Faisal University (SA)
Corresponding author: Nair, Anroop B.
ORCID: Acharjee, Satarupa
Nair, Anroop B.
Venue: Canadian Journal of Diabetes
Publisher: Elsevier BV
Published: 2013-08
Volume: 37
Issue: 4
Pages: 269-276
ISSN: 1499-2671 (ISSN-L)
DOI: 10.1016/j.jcjd.2013.05.001
OpenAlex: W2114256982
Cited by: 117
References: 52
Citations by year: 2026: 4 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 20 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 1
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Canadian Journal of Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, etiology, animal models of diabetes, genetic susceptibility, environmental triggers, gene transfer, islet cell destruction, pathophysiology
MeSH terms: Animals, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Animals, Genetically Modified, Biomedical Research

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Understanding Type 1 Diabetes: Etiology and Models

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