The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Understanding Type 1 Diabetes: Etiology and Models
Abstract
Type 1 diabetes is a complex disease involving a combination of factors, such as genetic susceptibility, immunologic dysregulation and exposure to environmental triggers. Animal models serve an important function both in elucidating the pathophysiology and preliminary screening of antidiabetic molecules. Hence, the development of models for type 1 diabetes can be broadly divided into 3 categories, namely: identification of spontaneously developing type 1 diabetes mellitus strains, creating diabetes-prone species through gene transfer techniques and forced destruction of islet cells through chemical or surgical means. This review discusses the models used to study type 1 diabetes with special emphasis on genetics.
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“Both obesity and hyperglycemia promote the release of inflammatory mediators, like TNF-α, or IL-6, released mediators stimulate macrophages and other innate immune cells, as well as some apoptosis-related signaling pathways, such as Fas/FasL signaling pathway (78, 79).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [78]
Citations
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Metadata
- Authors
- Acharjee, S., Ghosh, B., Al-Dhubiab, B. E., & Nair, A. B.
- Affiliations
- King Faisal University (SA)
- Corresponding author
- Nair, Anroop B.
- Venue
- Canadian Journal of Diabetes
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 37
- Issue
- 4
- Pages
- 269-276
- ISSN
- 1499-2671 (ISSN-L)
- OpenAlex
- W2114256982
- Cited by
- 117
- References
- 52
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 20 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, etiology, animal models of diabetes, genetic susceptibility, environmental triggers, gene transfer, islet cell destruction, pathophysiology
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Animals, Genetically Modified, Biomedical Research
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