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Cited by 271

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Incremental Prognostic Value of Gated Rb-82 Positron Emission Tomography Myocardial Perfusion Imaging Over Clinical Variables and Rest LVEF

Open access
Dorbala, Sharmila, Hachamovitch, Rory, Curillova, Zelmira, Thomas, Deepak, Vangala, Divya, Kwong, Raymond Y., Di Carli, Marcelo F.·2009·JACC: Cardiovascular Imaging
DOI 10.1016/j.jcmg.2009.04.009
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Abstract

OBJECTIVES This investigation sought to study the incremental value of gated rubidium (Rb)-82 positron emission tomography (PET) myocardial perfusion imaging (MPI) over clinical variables for predicting survival and future cardiac events. BACKGROUND The prognostic value of Rb-82 PET-MPI and left ventricular ejection fraction (LVEF) reserve (stress minus rest LVEF) is not well defined. METHODS 1,432 consecutive patients undergoing gated rest/vasodilator stress rubidium-82 PET were followed up for at least 1 year. Of these, rest and peak stress LVEF and LVEF reserve were available in 985 patients. Cardiac events (CE) including cardiac death or nonfatal myocardial infarction and all-cause death were assessed. RESULTS Over a mean follow-up of 1.7 ± 0.7 years, 83 (5.8%) CE and 140 (9.7%) all-cause death were observed. There was an increase in risk for both end points with an increasing percentage of abnormal and ischemic myocardium. With normal, mild, moderate, or severely ischemic scans, the observed annualized rates of CE were 0.7%, 5.5%, 5%, and 11% and of all-cause death were 3.3%, 7.2%, 6.9%, and 12.5%, respectively. In 985 patients with peak stress gated data, the observed annualized rates of CE (2.1% vs. 5.3%, p < 0.001) and all-cause death (4.3% vs. 9.2%, p < 0.001) were higher in patients with an LVEF reserve <0% compared with those with an LVEF reserve ≥0%. On Cox proportional hazards analysis, after consideration of clinical, historical, and rest LVEF information, stress PET results and LVEF reserve yielded incremental prognostic value with respect to both CE and all-cause death. CONCLUSIONS Vasodilator stress Rb-82 PET-MPI provides incremental prognostic value to historical/clinical variables and rest LVEF to predict survival free of CE and all-cause death. An increasing percentage of ischemia on PET-MPI is associated with an increase in the risk of CE and all-cause death. Left ventricular ejection fraction reserve provides significant independent and incremental value to Rb-82 MPI for predicting the risk of future adverse events.

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Metadata

Authors
Dorbala, S., Hachamovitch, R., Curillova, Z., Thomas, D., Vangala, D., Kwong, R. Y., & Di Carli, M. F.
Venue
JACC: Cardiovascular Imaging
Publisher
Elsevier BV
Published
2009-07
Volume
2
Issue
7
Pages
846-854
ISSN
  • 1876-7591 (ISSN-L)
  • 1936-878X
DOI
10.1016/j.jcmg.2009.04.009
OpenAlex
W1965946172
Cited by
271
References
16
FWCI
14.09
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Incremental Prognostic Value of Gated Rb-82 Positron Emission Tomography Myocardial Perfusion Imaging Over Clinical Variables and Rest LVEF. https://app.cochat.ai/papers/10.1016/j.jcmg.2009.04.009
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Dorbala, S., Hachamovitch, R., Curillova, Z., Thomas, D., Vangala, D., Kwong, R. Y., & Di Carli, M. F. (2009). Incremental Prognostic Value of Gated Rb-82 Positron Emission Tomography Myocardial Perfusion Imaging Over Clinical Variables and Rest LVEF. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2009.04.009

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