Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?

Cancer statistics, 2020

Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555

Wnt/β-catenin signaling and disease

Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

Lessons from hereditary colorectal cancer

Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

β‐catenin is a target for the ubiquitin–proteasome pathway

Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,586

Identification of FAP Locus Genes from Chromosome 5q21

Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,331

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,152

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

De Roock, W., Claes, B., Bernasconi, D., De Schutter, J., Biesmans, B., Fountzilas, G., Kalogeras, K. T., Kotoula, V., Papamichael, D., Laurent-Puig, P., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70130-3 · Cited by 2,144

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Huang, S.-M. A., Mishina, Y., Liu, S.-M., Cheung, A. K., Stegmeier, F., Michaud, G., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., et al. (2009) · Nature · doi:10.1038/nature08356 · Cited by 2,077

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., Hedge, P., et al. (1991) · Science · doi:10.1126/science.1651563 · Cited by 1,891

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C. J., Munemitsu, S. M., & Polakis, P. G. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,420

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Chen, B., Dodge, M. E., Tang, W., Lü, J., Ma, Z., Fan, C.-W., Wei, S., Hao, W., Kilgore, J. A., Williams, N. S., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.137 · Cited by 1,402

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, J. D., Faber, A. L., Horn, C. L., Donoho, G. P., Briggs, S., Robbins, C. M., Hostetter, G. H., Boguslawski, S. J., Moses, T. Y., Savage, S., et al. (2007) · Nature · doi:10.1038/nature05933 · Cited by 1,322

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Holz, M. K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2005) · Cell · doi:10.1016/j.cell.2005.10.024 · Cited by 1,262

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Haar, E. V., Lee, S.-I., Bandhakavi, S., Griffin, T. J., & Kim, D. (2007) · Nature Cell Biology · doi:10.1038/ncb1547 · Cited by 1,227

Association of the APC Gene Product with β-Catenin

Rubinfeld, B., Souza, B., Albert, I., Müller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S. M., & Polakis, P. G. (1993) · Science · doi:10.1126/science.8259518 · Cited by 1,223

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., & Sabatini, D. M. (2009) · Cell · doi:10.1016/j.cell.2009.03.046 · Cited by 1,202

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P., Birchmeier, W., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1184-1193.2002 · Cited by 1,198

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J.-P., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,128

The LKB1 tumor suppressor negatively regulates mTOR signaling

Shaw, R. J., Bardeesy, N. M., Manning, B. D., Lopez, L. V., Kosmatka, M., DePinho, R. A., & Cantley, L. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.007 · Cited by 1,107

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3870 · Cited by 1,088

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,080

The emerging roles of forkhead box (Fox) proteins in cancer

Myatt, S. S., & Lam, E. W. ‐. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2223 · Cited by 1,077

The -Catenin Destruction Complex

Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007898 · Cited by 1,062

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

Kim, D., Sarbassov, D. D., Ali, S. M., Latek, R. R., Guntur, K., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00114-x · Cited by 992

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Koo, B.-K., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M., et al. (2012) · Nature · doi:10.1038/nature11308 · Cited by 980

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Hao, H.-X., Xie, Y., Zhang, Y., Charlat, O., Oster, E., Avello, M., Lei, H., Mickanin, C., Liu, D., Ruffner, H., et al. (2012) · Nature · doi:10.1038/nature11019 · Cited by 962

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

Li, V. S. W., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.002 · Cited by 889

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 872

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., Kasibhatla, S., Schuller, A. G., Li, A. G., Cheng, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314239110 · Cited by 851

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

Hart, M. J., Santos, R. D. L., Albert, I., Rubinfeld, B., & Polakis, P. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70226-x · Cited by 850

Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion

Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 809

Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition

Sun, S., Rosenberg, L. M., Wang, X., Zhou, Z., Yue, P., Fu, H., & Khuri, F. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0917 · Cited by 800

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 724

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

Frame, S., Cohen, P., & Biondi, R. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00253-2 · Cited by 724

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Lee, E., Salic, A., Krüger, R., Heinrich, R., & Kirschner, M. W. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000010 · Cited by 708

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Frías, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W. A., Sculley, T. B., Carr, S. A., & Sabatini, D. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.001 · Cited by 690

Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

Beretta, L., Gingras, A., Svitkin, Y. V., Hall, M. N., & Sonenberg, N. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00398.x · Cited by 673

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T. J., Hunziker, W., McNeill, H., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.007 · Cited by 597

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594

An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.-I., & Nakayama, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2401 · Cited by 529

GSK-3: Functional Insights from Cell Biology and Animal Models

Kaidanovich‐Beilin, O., & Woodgett, J. R. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00040 · Cited by 505

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

Dann, C. E., Hsieh, J.-C., Rattner, A., Sharma, D., Nathans, J., & Leahy, D. J. (2001) · Nature · doi:10.1038/35083601 · Cited by 473

Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 458

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Wee, S., Jagani, Z., Xiang, K. X., Loo, A., Dorsch, M., Yao, Y.-M., Sellers, W. R., Lengauer, C., & Stegmeier, F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4765 · Cited by 455

Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling

Ding, V. W., Chen, R., & McCormick, F. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005342200 · Cited by 429

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

Cheng, X., Xu, X., Chen, D., Zhao, F., & Wang, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.082 · Cited by 427

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

Memmott, R. M., & Dennis, P. A. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.004 · Cited by 392

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

Tenbaum, S. P., Ordóñez‐Morán, P., Puig, I., Chicote, I., Arqués, O., Landolfi, S., Fernández, Y., Herance, J. R., Gispert, J. D., Mendizabal, L., et al. (2012) · Nature Medicine · doi:10.1038/nm.2772 · Cited by 390

Wnt signaling in adult intestinal stem cells and cancer

Krausová, M., & Kořínek, V. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.032 · Cited by 380

Activation of AXIN2 Expression by β-Catenin-T Cell Factor

Leung, J. Y., Kolligs, F. T., WU, R. T., Zhai, Y., Kuick, R. D., Hanash, S., Cho, K. R., & Fearon, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200139200 · Cited by 355

Mutations in the RAS‐MAPK, PI(3)K (phosphatidylinositol‐3‐OH kinase) signaling network correlate with poor survival in a population‐based series of colon cancers

Barault, L., Veyrie, N., Jooste, V., Corre, D. L., Chapusot, C., Ferraz, J., Lièvre, A., Cortet, M., Bouvier, A., Rat, P., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23388 · Cited by 352

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

Madan, B., Ke, Z., Harmston, N., Ho, S. Y., Frois, A. O., Alam, J., Jeyaraj, D. A., Pendharkar, V. V., Ghosh, K., Virshup, I., et al. (2015) · Oncogene · doi:10.1038/onc.2015.280 · Cited by 343

Mutation Profiling and Microsatellite Instability in Stage II and III Colon Cancer: An Assessment of Their Prognostic and Oxaliplatin Predictive Value

Gavin, P. G., Colangelo, L. H., Fumagalli, D., Tanaka, N., Remillard, M. Y., Yothers, G., Kim, C., Taniyama, Y., Kim, S. I., Choi, H. J., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0605 · Cited by 320

Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F., Schweizer, L., & Varmus, H. (2004) · Development · doi:10.1242/dev.01318 · Cited by 317

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth

Lau, T., Chan, E., Callow, M., Waaler, J., Boggs, J., Blake, R. A., Magnuson, S., Sambrone, A., Schutten, M., Firestein, R., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4562 · Cited by 316

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

Faller, W. J., Jackson, T. J., Knight, J. R. P., Ridgway, R. A., Jamieson, T. J., Karim, S. A., Jones, C., Radulescu, S., Huels, D. J., Myant, K., et al. (2014) · Nature · doi:10.1038/nature13896 · Cited by 315

S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt

Zhang, H. H., Lipovsky, A. I., Dibble, C. C., Şahin, M., & Manning, B. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.09.019 · Cited by 309

Frequent Inactivation of PTEN by Promoter Hypermethylation in Microsatellite Instability-High Sporadic Colorectal Cancers

Goel, A., Arnold, C. N., Niedzwiecki, D., Carethers, J. M., Dowell, J. M., Wasserman, L., Compton, C., Mayer, R. J., Bertagnolli, M. M., & Boland, C. R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2401-2 · Cited by 302

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

Zheng, X.-F., Fiorentino, D. F., Chen, J., Crabtree, G. R., & Schreiber, S. L. (1995) · Cell · doi:10.1016/0092-8674(95)90058-6 · Cited by 300

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

Raup‐Konsavage, W. M., Kyler, S. L., Rennoll, S. A., Jin, G., & Yochum, G. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327767 · Cited by 277

Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship

Jhanwar-Uniyal, M., Wainwright, J. V., Mohan, A. L., Tobias, M. E., Murali, R., Gandhi, C. D., & Schmidt, M. H. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.03.003 · Cited by 268

Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities

Topisirovic, I., Ruiz-Gutierrez, M., & Borden, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2677 · Cited by 267

Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

Liao, X., Morikawa, T., Lochhead, P., Imamura, Y., Kuchiba, A., Yamauchi, M., Nosho, K., Qian, Z. R., Nishihara, R., Meyerhardt, J. A., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2410 · Cited by 258

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S.-I., Natsume, T., & Mizushima, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121699 · Cited by 255

Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology

Ellis, L. M., & Hicklin, D. J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1070 · Cited by 254

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.072132 · Cited by 214

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

Piao, S., Lee, S., Kim, H., Yum, S., Stamos, J. L., Xu, Y., Lee, S. J., Lee, J., Oh, S., Han, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004046 · Cited by 212

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 199

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

Fearnhead, N. S., Wilding, J. L., WINNEY, B. J., Tonks, S., Bartlett, S., Bicknell, D., Tomlinson, I. P. M., Mortensen, N. J. M., & Bodmer, W. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407187101 · Cited by 196

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S., & Alessi, D. R. (2011) · Biochemical Journal · doi:10.1042/bj20102103 · Cited by 189

PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers

Zhou, X.-P., Loukola, A., Salovaara, R., Nyström, M., Peltomäki, P., de la Chapelle, A., Aaltonen, L. A., & Eng, C. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64200-9 · Cited by 185

Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability.

Duval, A., Gayet, J., Zhou, X., Iacopetta, B. M., Thomas, G. D., & Hamelin, R. (1999) · PubMed · Cited by 182

Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer

Arqués, O., Chicote, I., Puig, I., Tenbaum, S. P., Argilés, G., Dienstmann, R., Fernández, N., Caratù, G., Matito, J., Silberschmidt, D., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3081 · Cited by 179

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesisPreprint

Cai, J., Maitra, A., Anders, R. A., Taketo, M. M., & Pan, D. (2015) · Genes & Development · doi:10.1101/gad.264515.115 · Cited by 176

Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth

Acosta-Jaquez, H. A., Keller, J. A., Foster, K. G., Üstünel, B. E., Soliman, G. A., Feener, E. P., Ballif, B. A., & Fingar, D. C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01665-08 · Cited by 171

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc Δ716 mice

Fujishita, T., Aoki, K., Lane, H. A., Aoki, M., & Taketo, M. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800041105 · Cited by 167

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

Waaler, J., Machoň, O., von Kries, J. P., Wilson, S. R., Lundenes, E., Wedlich, D., Gradl, D., Paulsen, J. E., Machoňová, O., Dembinski, J. L., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1282 · Cited by 167

Eukaryotic Translation Initiation Factor 4E–Induced Progression of Primary Human Mammary Epithelial Cells along the Cancer Pathway Is Associated with Targeted Translational Deregulation of Oncogenic Drivers and Inhibitors

Larsson, O. S., Li, S., Issaenko, O. A., Avdulov, S. V., Peterson, M., Smith, K. A., Bitterman, P. B., & Polunovsky, V. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0752 · Cited by 165

PIK3CA Activating Mutation in Colorectal Carcinoma: Associations with Molecular Features and Survival

Rosty, C., Young, J. P., Walsh, M. D., Clendenning, M., Sanderson, K., Walters, R., Parry, S., Jenkins, M. A., Win, A. K., Southey, M. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065479 · Cited by 152

Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation

Wang, X., Yue, P., Chan, C. B., Ye, K., Ueda, T., Watanabe‐Fukunaga, R., Fukunaga, R., Fu, H., Khuri, F. R., & Sun, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00760-07 · Cited by 149

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 Phosphorylation

He, L., Gomes, A. P., Wang, X., Yoon, S. O., Lee, G., Nagiec, M. J., Cho, S., Chavez, A., Islam, T., Yu, Y., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.04.024 · Cited by 145

Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Lim, S., Saw, T. Y., Zhang, M., Janes, M. R., Nacro, K., Hill, J., Lim, A. Q., Chang, C.-T., Fruman, D. A., Rizzieri, D. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301838110 · Cited by 145

Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin Facilitates Glycogen Synthase Kinase-3β-dependent Phosphorylation of β-Catenin and Down-regulates β-Catenin

Hinoi, T., Yamamoto, H., Kishida, M., Takada, S., Kishida, S., & Kikuchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003997200 · Cited by 136

Kinetic Responses of β-Catenin Specify the Sites of Wnt Control

Hernandez, A., Klein, A. M., & Kirschner, M. W. (2012) · Science · doi:10.1126/science.1228734 · Cited by 134

Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice

Huang, J. Y., Zhang, Y., Bersenev, A., O’Brien, W. T., Tong, W., Emerson, S. G., & Klein, P. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40572 · Cited by 131

DNA Sequence Profiles of the Colorectal Cancer Critical Gene Set KRAS-BRAF-PIK3CA-PTEN-TP53 Related to Age at Disease Onset

Berg, M., Danielsen, S. A., Ahlquist, T. C., Merok, M. A., Ågesen, T. H., Vatn, M. H., Mala, T., Sjo, O. H., Bakka, A. O., Moberg, I. O., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013978 · Cited by 129

Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

Proffitt, K. D., & Virshup, D. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.381970 · Cited by 127

PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer

Day, F. L., Jorissen, R. N., Lipton, L. R., Mouradov, D., Sakthianandeswaren, A., Christie, M., Li, S., Tsui, C., Tie, J., Desai, J., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3614 · Cited by 125

First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer

Shapiro, G. I., Bell‐McGuinn, K. M., Molina, J. R., Bendell, J. C., Spicer, J. F., Kwak, E. L., Pandya, S. S., Millham, R., Borzillo, G. V., Pierce, K. J., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1306 · Cited by 123

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

Guanti, G. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.283 · Cited by 123

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

Zhang, J., Roberts, T. M., & Shivdasani, R. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.05.010 · Cited by 122

The Oncogene eIF4E: Using Biochemical Insights to Target Cancer

Carroll, M. P., & Borden, K. L. B. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0142 · Cited by 115

A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer

Bendell, J. C., Varghese, A. M., Hyman, D. M., Bauer, T. M., Pant, S., Callies, S., Lin, J., Martínez, R., Wickremsinhe, E. R., Fink, A. A., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3421 · Cited by 110

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1

Zhong, Y., Katavolos, P., Nguyen, T., Lau, T., Boggs, J. W., Sambrone, A., Kan, D., Merchant, M. A., Harstad, E. B., Diaz, D., et al. (2015) · Toxicologic Pathology · doi:10.1177/0192623315621192 · Cited by 107

A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors

Bendell, J. C., Kurkjian, C. D., Infante, J. R., Bauer, T. M., Burris, H. A., Greco, F. A., Shih, K. C., Thompson, D. S., Lane, C. M., Finney, L. H., et al. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0218-6 · Cited by 101

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

Avizienyte, E., Roth, S., Loukola, A., Hemminki, A., Lothe, R. A., Stenwig, A. E., Fosså, S. D., Salovaara, R., & Aaltonen, L. A. (1998) · PubMed · Cited by 101

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity

Valvezan, A. J., Zhang, F., Diehl, J. A., & Klein, P. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323337 · Cited by 100

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

Saito‐Diaz, K., Benchabane, H., Tiwari, A., Tian, A., Li, B., Thompson, J. J., Hyde, A. S., Sawyer, L. M., Jodoin, J. N., Santos, E., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.02.013 · Cited by 97

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors

Papadopoulos, K. P., Tabernero, J. M., Markman, B., Patnaik, A., Tolcher, A. W., Baselga, J. M., Shi, W., Égile, C., Ruiz-Soto, R., Laird, A., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2403 · Cited by 96

Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth

Wang, Q., Zhou, Y., Rychahou, P. G., Harris, J. W., Zaytseva, Y. Y., Liu, J., Wang, C., Weiss, H. L., Liu, C., Lee, E. Y., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3107 · Cited by 95

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

Dong, S. M., Kim, K. M., Kim, S. Y., Shin, M. S., Na, E. Y., Lee, S. H., Park, W. S., Yoo, N. J., Jang, J. J., Yoon, C. Y., et al. (1998) · PubMed · Cited by 89

Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.

Berkel, H. J., Turbat‐Herrera, E. A., Shi, R., & Benedetti, A. D. (2001) · PubMed · Cited by 87

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

Zhong, Z., Sepramaniam, S., Chew, X. H., Wood, K. C., Lee, M. A., Madan, B., & Virshup, D. M. (2019) · Oncogene · doi:10.1038/s41388-019-0908-1 · Cited by 86

PIK3CA and APC mutations are synergistic in the development of intestinal cancers

Deming, D. A., Leystra, A. A., Nettekoven, L. A., Sievers, C. K., Miller, D. L., Middlebrooks, M., Clipson, L. J., Albrecht, D. M., Bacher, J. W., Washington, M. K., et al. (2013) · Oncogene · doi:10.1038/onc.2013.167 · Cited by 83

mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

Zeng, H., Lu, B., Zamponi, R., Yang, Z., Wetzel, K., Loureiro, J., Mohammadi, S., Beibel, M., Bergling, S., Reece-Hoyes, J. S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808575115 · Cited by 82

Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens

Ng, K., Tabernero, J. M., Hwang, J. J., Bajetta, E., Sharma, S., Prete, S. A. D., Arrowsmith, E. R., Ryan, D. P., Šedová, M., Jin, J., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0027 · Cited by 75

Wnt pathway activation by ADP-ribosylation

Yang, E., Tacchelly‐Benites, O., Wang, Z., Randall, M. P., Tian, A., Benchabane, H., Freemantle, S. J., Pikielny, C. W., Tolwinski, N. S., Lee, E. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11430 · Cited by 69

Detection of point mutations of the Axin1 gene in colorectal cancers

Jin, L., Shao, Q., Luo, W., Ye, Z., Li, Q., & Lin, S. (2003) · International Journal of Cancer · doi:10.1002/ijc.11435 · Cited by 68

mTOR complex 1 controls the nuclear localization and function of glycogen synthase kinase 3β

Bautista, S. J., Boras, I., Vissa, A., Mecica, N., Yip, C. M., Kim, P. K., & Antonescu, C. N. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002800 · Cited by 67

Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

Park, Y., Kim, H., Cho, Y., Min, D., Cheon, S., Lim, Y., Song, S., Kim, S. J., Han, S., Park, K. J., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31662 · Cited by 66

Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein–protein interfaces of nuclear factors

Zimmerli, D., Hausmann, G., Cantù, C., & Basler, K. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13864 · Cited by 65

Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations

Foley, T. M., Payne, S. N., Pasch, C. A., Yueh, A. E., Hey, D. R. V. D., Korkos, D. P., Clipson, L. J., Maher, M. E., Matkowskyj, K. A., Newton, M. A., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0256 · Cited by 64

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Picco, G., Petti, C., Centonze, A., Torchiaro, E., Crisafulli, G., Novara, L., Acquaviva, A., Bardelli, A., & Médico, E. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606773 · Cited by 62

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice

Koehl, G. E., Spitzner, M., Ousingsawat, J., Schreiber, R., Geissler, E. K., & Kunzelmann, K. (2009) · Oncogene · doi:10.1038/onc.2009.435 · Cited by 59

PTEN gene mutations in colorectal cancers displaying microsatellite instability

Shin, K. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00691-7 · Cited by 59

Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: Outcome and results of KRAS mutational analysis in plasma

Spindler, K. G., Mau‐Sørensen, M., Pallisgaard, N., Andersen, R. F., Havelund, B. M., Pløen, J., Lassen, U., & Jakobsen, A. K. M. (2013) · Acta Oncologica · doi:10.3109/0284186x.2013.776175 · Cited by 59

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

Isinger-Ekstrand, A., Jönsson, M., Lindblom, A., Borg, Å., & Nilbert, M. C. (2009) · Familial Cancer · doi:10.1007/s10689-009-9293-1 · Cited by 55

mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

Brandt, M., Grazioso, T. P., Fawal, M.-A., Tummala, K. S., Torres-Ruiz, R., Rodríguez, S., Perna, C., & Djouder, N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.006 · Cited by 53

TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer

Solberg, N. T., Waaler, J., Lund, K., Mygland, L., Olsen, P. A., & Krauss, S. J. K. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0362 · Cited by 53

Colorectal carcinomas and PTEN/MMAC1 gene mutations.

Dicuonzo, G., Angeletti, S., García‐Foncillas, J., Brugarolas, A., Okrouzhnov, Y., Santini, D., Tonini, G., Lorino, G., Cesaris, M. D., & Baldi, A. (2001) · PubMed · Cited by 53

Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth

Koo, J., Yue, P., Gal, A. A., Khuri, F. R., & Sun, S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2946 · Cited by 49

Development and applications of a beta-catenin oligonucleotide microarray: beta-catenin mutations are dominantly found in the proximal colon cancers with microsatellite instability.

Kim, I.-J., Kang, H. C., Park, J.-H., Shin, Y. S., Ku, J., Lim, S., Park, S. Y., Jung, S. Y., Kim, H. K., & Park, J. (2003) · PubMed · Cited by 49

Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy

Li, Z., Sun, Y., Qu, M., Wan, H., Cai, F., & Zhang, P. (2016) · Oncotarget · doi:10.18632/oncotarget.13772 · Cited by 45

The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

Quackenbush, K. S., Bagby, S. M., Tai, W. M. D., Messersmith, W. A., Schreiber, A., Greene, J., Kim, J., Wang, G., Purkey, A., Pitts, T. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8626 · Cited by 43

Novel mutations of the suppressor genePTENin colorectal carcinomas stratified by microsatellite instability- andTP53mutation- status

Danielsen, S. A., Lind, G. E., Bjørnslett, M., Meling, G. I., Rognum, T. O., Heim, S., & Lothe, R. A. (2008) · Human Mutation · doi:10.1002/humu.20860 · Cited by 42

Rapamycin Inhibition of Polyposis and Progression to Dysplasia in a Mouse Model

Hardiman, K. M., Liu, J., Feng, Y., Greenson, J. K., & Fearon, E. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096023 · Cited by 41

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

Thorne, C. A., Wichaidit, C., Coster, A. D., Posner, B. A., Wu, L. F., & Altschuler, S. J. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1690 · Cited by 40

MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers

Fricke, S. L., Payne, S. N., Favreau, P. F., Kratz, J. D., Pasch, C. A., Foley, T. M., Yueh, A. E., Hey, D. R. V. D., Depke, M. G., Korkos, D. P., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0510 · Cited by 40

Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations

Moon, J.-H., Hong, S., Kim, J. E., Shin, J.-S., Kim, J.-S., Jung, S.-A., Ha, S. H., Lee, S., Kim, J., Lee, D. H., et al. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0434-5 · Cited by 34

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1)in mice and zebrafish

Valvezan, A. J., Huang, J. Y., Lengner, C. J., Pack, M. A., & Klein, P. S. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012625 · Cited by 31

mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Mashima, T., Taneda, Y., Jang, M.-K., Mizutani, A., Muramatsu, Y., Yoshida, H., Sato, A., Tanaka, N., Sugimoto, Y., & Seimiya, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18146 · Cited by 31

Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis

Li, L., Xu, T., Zong, Y., Peng, L., Kong, S., Zhou, M., Zou, J., Liu, J., Miao, R., & Sun, X. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s98330 · Cited by 29

T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis.

Ruckert, S., Hiendlmeyer, E., Brueckl, W. M., Oswald, U., Beyser, K., Dietmaier, W., Haynl, A., Koch, C., Rüschoff, J., Brabletz, T., et al. (2002) · PubMed · Cited by 28

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

He, L., Fei, D. L., Nagiec, M. J., Mutvei, A. P., Lamprakis, A. A., Kim, B. Y., & Blenis, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902397116 · Cited by 25

Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics

Mukherjee, A., Dhar, N., Stathos, M., Schaffer, D. V., & Kane, R. S. (2018) · iScience · doi:10.1016/j.isci.2018.07.007 · Cited by 24

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Russo, M., Lamba, S., Lorenzato, A., Sogari, A., Corti, G., Rospo, G., Mussolin, B., Montone, M., Lazzari, L., Arena, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04506-z · Cited by 20

APC Moonlights to Prevent Wnt Signalosome Assembly

McGough, I. J., & Vincent, J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.02.018 · Cited by 9

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Singh, V., Lee, G., Son, H., Koh, H., Kim, E. S., Unno, T., & Shin, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1103836 · Cited by 784

Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546

RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target

Chen, H., Gao, S., Liu, W., Wong, C.-C., Wu, J., Wu, J., Liu, D., Gou, H., Kang, W., Zhai, J., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.11.013 · Cited by 308

PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment

Leiphrakpam, P., & Are, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063178 · Cited by 193

Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer

Akbarzadeh, M., Mihanfar, A., Akbarzadeh, S., Yousefi, B., & Majidinia, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119984 · Cited by 112

Potential Targets for Prevention of Colorectal Cancer: a Focus on PI3K/Akt/mTOR and Wnt Pathways

Pandurangan, A. K. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.4.2201 · Cited by 198

Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status

Fleming-de-Moraes, C. D., Rocha, M. R., Tessmann, J. W., de Araújo, W. M., & Morgado‐Díaz, J. A. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2108690 · Cited by 93

Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review

Ma, S., Li, L., Cai, H., Guo, T., & Zhang, L. (2023) · World Journal of Clinical Oncology · doi:10.5306/wjco.v14.i2.81 · Cited by 18

PI3K/ Akt/ mTOR Pathway as a Therapeutic Target for Colorectal Cancer: A Review of Preclinical and Clinical Evidence

Narayanankutty, A. (2019) · Current Drug Targets · doi:10.2174/1389450120666190618123846 · Cited by 267

PI3K and tankyrase inhibitors as therapeutic targets in colorectal cancer

Yakkala, P. A., Naaz, F., Shafi, S., & Kamal, Ä. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2331015 · Cited by 8