The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING–NF-κB Signaling Pathway
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“Previous studies have demonstrated that SCAP is involved in the molecular mechanisms linking cholesterol metabolism directly to NLRP3 inflammasome activation19 and nuclear factor kappa B (NF-κB) signaling20.”
In the citing paper
“Recent findings highlight that the Golgi apparatus, as a signaling hub for NF-κB, is essential for NF-κB–C3 activation20,86.”
In the citing paper
“SCAP plays a key role in metabolic diseases by regulating inflammatory signaling pathways linked to cholesterol disorders19,20, such as SCAP-mediated Golgi trafficking in NF-κB activation.”
In the citing paper
“SCAP, a cholesterol sensitizer, bridges metabolism and inflammation and amplifies inflammatory mediator production in metabolic diseases, particularly in cholesterol homeostasis disorders19,20.”
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Citations
Cites
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“adipocyte lipolysis is dysregulated, lipids can accumulate in ectopic tissues such as the liver, leading to insulin insensitivity and NAFLD.(36) Lipodystrophy is associated with an inflammatory environment, especially inflammatory factors released by activated macrophages, which stimulate lipolysis by increasing the e…”
BackgroundDNA sensing by the cGAS–STING pathway in health and disease
Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467
Liver inflammation and fibrosis
Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · cited 1×
“The activation of hepatic macrophages and subsequent secretion of proinflammatory mediators lead to increased lipid accumulation and damage in hepatocytes, which are critical events in the development and progression of NAFLD.(39,40) PD causes macrophage infiltration and abnormal SCAP expression in macrophages, produc…”
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Research works printed but not linked: 39
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Cited by
Sorted by citations
Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81
“Moreover, macrophage-speci fi c Scap deletion ameliorated metain fl ammation and ectopic lipid deposition by promoting the release of in fl ammatory mediators by recruiting STING and tank-binding kinase 1 to the Golgi to activate the NF-κ B signaling pathway [107].”
Self-citationNiu, T., Wang, S., Zhang, H., Zhu, W., Liu, K., Zhou, X., Sun, R., Niu, D., & Yuan, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01534-w · Cited by 7
Metadata
- Authors
- Huang, X., Yao, Y., Hou, X., Wei, L., Rao, Y., Su, Y., Zheng, G., Ruan, X. Z., Li, D., & Chen, Y.
- Venue
- Cellular and Molecular Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2022
- Volume
- 14
- Issue
- 1
- Pages
- 1-26
- ISSN
- 2352-345X
- PMC
- PMC9117819
- Cited by
- 70
- References
- 4
- Language
- en
- Licence
- Funders
- Higher Education Discipline Innovation Project (D20028)
- National Natural Science Foundation of China (81900406, 82170586)
- China Postdoctoral Science Foundation (2019M663448)
- Chongqing Medical University
- Natural Science Foundation of Chongqing (CSTC2019JCYJ-BSHX0094)
- Chongqing Research Program of Basic Research and Frontier Technology (cstc2020jcyj-zdxmX0007)
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