Cited by 2,286RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryVirus-based gene therapy research

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, Hongtao, Zhang, Shubiao, Wang, Bing, Cui, Shaohui, Yan, Jie·2006·Journal of Controlled Release

DOI 10.1016/j.jconrel.2006.04.014

Open this paper in CoChat — free account

Abstract

Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds.

Integrity signals

Registry

Crossref · 10.1016/j.jconrel.2006.04.014

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.
Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y.-L., Border, R., Ramsey, P., Martin, M. U., & Felgner, P. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41980-6 · Cited by 1,313
A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity
Fischer, D., Bieber, T., Li, Y., Elsässer, H., & Kissel, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1014861900478 · Cited by 1,219
Poly(ethylenimine) and its role in gene delivery
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00090-5 · Cited by 1,200
Polyethylenimine-based non-viral gene delivery systems
Lungwitz, U., Breunig, M., Blunk, T., & Göpferich, A. M. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.11.011 · Cited by 998
Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.
Wu, G. Y., & Wu, C. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61209-8 · Cited by 855
Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990605)45:3 · Cited by 833
Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
Kunath, K. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00076-2 · Cited by 809
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)
Artursson, P., Lindmark, T., Davis, S. S., & Illum, L. (1994) · Pharmaceutical Research · doi:10.1023/a:1018967116988 · Cited by 766
Improved DNA: liposome complexes for increased systemic delivery and gene expression
Templeton, N. S., Lasiç, D. D., Frederik, P. M., Strey, H. H., Roberts, D. D., & Pavlakis, G. N. (1997) · Nature Biotechnology · doi:10.1038/nbt0797-647 · Cited by 740
An overview of current delivery systems in cancer gene therapy
El‐Aneed, A. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.09.013 · Cited by 694
A triploblast origin for Myxozoa?
Anderson, C. L., Canning, E. U., & Okamura, B. (1998) · Nature · doi:10.1038/32801 · Cited by 654
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
Illum, L., Farraj, N. F., & Davis, S. S. (1994) · Pharmaceutical Research · doi:10.1023/a:1018901302450 · Cited by 630
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
Hafez, I., Maurer, N., & Cullis, P. R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301506 · Cited by 601
Polyethylenimine-graft-Poly(ethylene glycol) Copolymers: Influence of Copolymer Block Structure on DNA Complexation and Biological Activities as Gene Delivery System
Petersen, H., Fechner, P. M., Martin, A. L., Kunath, K., Stolnik, S., Roberts, C. J., Fischer, D., Davies, M. C., & Kissel, T. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025529v · Cited by 534
Mode of formation and structural features of DNA-cationic liposome complexes used for transfection
Gershon, H., Ghirlando, R., Gutman, S. B., & Minsky, A. (1993) · Biochemistry · doi:10.1021/bi00079a011 · Cited by 498
Formation and Intracellular Trafficking of Lipoplexes and Polyplexes
Elouahabi, A., & Ruysschaert, J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.006 · Cited by 464
Chitosan and its derivatives as intestinal absorption enhancers
Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00180-6 · Cited by 437
Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles
Leventis, R., & Silvius, J. R. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90017-i · Cited by 430
Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells
Filion, M. C., & Phillips, N. C. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00126-0 · Cited by 428
Development of Biomaterials for Gene Therapy
Han, S.-O., Mahato, R. I., Sung, Y. K., & Kim, S. W. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0142 · Cited by 388
Characterization of cationic lipid-protamine–DNA (LPD) complexes for intravenous gene delivery
Li, S., Rizzo, M., Bhattacharya, S. S., & Huang, L. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300683 · Cited by 369
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
Thomas, M., Lu, J. J.-Q., Ge, Q., Zhang, C. C., Chen, J., & Klibanov, A. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502067102 · Cited by 366
Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability
Godbey, W. T., Wu, K. K., & Mikos, A. G. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00203-9 · Cited by 361
A Nonviral DNA Delivery System Based on Surface Modified Silica-Nanoparticles Can Efficiently Transfect Cells in Vitro
Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H. K., & Lehr, C. (2000) · Bioconjugate Chemistry · doi:10.1021/bc0000637 · Cited by 360
Polycation-based DNA complexes for tumor-targeted gene delivery in vivo
Kircheis, R., Schüller, S., Brunner, S., Ogris, M., Heider, K., Zauner, W., & Wagner, E. (1999) · The Journal of Gene Medicine · doi:10.1002/(sici)1521-2254(199903/04)1:2 · Cited by 358
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies
Ruponen, M., Ylä‐Herttuala, S., & Urtti, A. O. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00199-0 · Cited by 352
Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes
Friend, D. S., Papahadjopoulos, D., & Debs, R. J. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00219-7 · Cited by 352
Polyethylenimine with acid-labile linkages as a biodegradable gene carrier
Kim, Y. H., Park, J. H., Lee, M., Kim, Y., Park, T. G., & Kim, S. W. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.008 · Cited by 328
Liposomes for Gene Delivery
Liu, D. (2004) · Dalian Minzu Xueyuan xuebao · Cited by 326
Cationic compounds used in lipoplexes and polyplexes for gene delivery
Zhang, S., Xu, Y., Wang, B., Qiao, W., Liu, D., & Li, Z. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.019 · Cited by 320
Self-citation
Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH
Funhoff, A. M., van Nostrum, C. F., Koning, G. A., Schuurmans-Nieuwenbroek, N. M. E., Crommelin, D. J. A., & Hennink, W. E. (2003) · Biomacromolecules · doi:10.1021/bm034041+ · Cited by 272
In Vitro Gene Transfection Using Dendritic Poly( l -lysine)
Ohsaki, M., Okuda, T., Wada, A., Hirayama, T., Niidome, T., & Aoyagi, H. (2002) · Bioconjugate Chemistry · doi:10.1021/bc015525a · Cited by 264
Polyelectrolyte Vectors for Gene Delivery: Influence of Cationic Polymer on Biophysical Properties of Complexes Formed with DNA
Wolfert, M. A., Dash, P. R., Nazarova, O. V., Oupický, D., Seymour, L. W., Smart, S., Strohalm, J., & Ulbrich, K. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990025r · Cited by 253
Water-Soluble and Low Molecular Weight Chitosan-Based Plasmid DNA Delivery
Lee, M., Nah, J., Kwon, Y. M., Koh, J. J., Ko, K. S., & Kim, S. W. (2001) · Pharmaceutical Research · doi:10.1023/a:1011037807261 · Cited by 240
Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity
Farhood, H., Bottega, R., Epand, R. M., & Huang, L. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90316-e · Cited by 240
Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids
Pouton, C. W., Lucas, P., Thomas, B. J., Uduehi, A. N., Milroy, D., & Moss, S. H. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00015-7 · Cited by 239
Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes
Lappalainen, K., Jääskeläinen, I., Syrjänen, K. J., Urtti, A. O., & Syrjänen, S. (1994) · Pharmaceutical Research · doi:10.1023/a:1018932714745 · Cited by 238
Novel Branched Poly(Ethylenimine)−Cholesterol Water-Soluble Lipopolymers for Gene Delivery
Wang, D., Narang, A. S., Kotb, M., Gaber, A. O., Miller, D. D., Kim, S. W., & Mahato, R. I. (2002) · Biomacromolecules · doi:10.1021/bm025563c · Cited by 237
Chitosan and its derivatives—a promising non-viral vector for gene transfection
Liu, W., & Yao, K. D. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00144-x · Cited by 236
Structure–activity relationships of poly(l-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery
Männistö, M., Vanderkerken, S., Toncheva, V., Elomaa, M. A., Ruponen, M., Schacht, E. H., & Urtti, A. O. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00178-5 · Cited by 232
Physicochemical Characterization and Purification of Cationic Lipoplexes
Xu, Y., Hui, S. W., Frederik, P. M., & Szoka, F. C. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)76894-3 · Cited by 229
Controlled release systems for DNA delivery
Pannier, A. K., & Shea, L. D. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.03.020 · Cited by 227
Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency
Godbey, W. T., Wu, K. K., Hirasaki, G. J., & Mikos, A. G. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300976 · Cited by 222
Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells
Pinnaduwage, P. D., Schmitt, L., & Huang, L. (1989) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(89)90099-0 · Cited by 213
Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo
Köping‐Höggård, M., Mel'nikova, Y. S., Vårum, K. M., Lindman, B., & Artursson, P. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.327 · Cited by 212
Water-Soluble Lipopolymer for Gene Delivery
Han, S., Mahato, R. I., & Kim, S. W. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000120w · Cited by 208
Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery
van der Woude, I., Wagenaar, A., Meekel, A. A. P., ter Beest, M. B. A., Ruiters, M. H. J., Engberts, J. B. F. N., & Hoekstra, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1160 · Cited by 208
Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy
Ward, C. M., Read, M. L., & Seymour, L. W. (2001) · Blood · doi:10.1182/blood.v97.8.2221 · Cited by 191
A Novel Series of Amphiphilic Imidazolinium Compounds for in Vitro and in Vivo Gene Delivery
Solodin, I., Brown, C. S., Bruno, M. S., Chow, C.-Y., Jang, E.-H., Debs, R. J., & Heath, T. D. (1995) · Biochemistry · doi:10.1021/bi00041a033 · Cited by 189
Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
Sakurai, F., Nishioka, T., Saito, H., Baba, T., Okuda, A., Matsumoto, O., Taga, T., Yamashita, F., Takakura, Y., & Hashida, M. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301460 · Cited by 175
Characters of dendritic poly(l-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro
Okuda, T., Sugiyama, A., Niidome, T., & Aoyagi, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00542-8 · Cited by 174
Low molecular weight polyethylenimines linked by β‐cyclodextrin for gene transfer into the nervous system
Tang, G., Guo, H., Alexis, F., Wang, X., Zeng, S., Lim, T. M., Ding, J. L., Yang, Y. Y., & Wang, S. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.874 · Cited by 169
The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids
Ouahabi, A. E., Thiry, M., Pector, V., Fuks, R., Ruysschaert, J., & Vandenbranden, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00973-3 · Cited by 163
Asialoglycoprotein Receptor-Mediated Gene Transfer Using Novel Galactosylated Cationic Liposomes
Kawakami, S., Yamashita, F., Nishikawa, M., Takakura, Y., & Hashida, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9602 · Cited by 159
Interaction of positively-charged liposomes with blood: implications for their application in vivo
Senior, J. H., Trimble, K. R., & Maskiewicz, R. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90160-a · Cited by 157
Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer
Heyes, J. A., Niculescu‐Duvaz, D., Cooper, R. G., & Springer, C. J. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010918g · Cited by 156
Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo
Bielinska, A. U., Yen, A., Wu, H. L., Zahos, K. M., Sun, R., Weiner, N. D., Baker, J. R., & Roessler, B. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00229-x · Cited by 151
Vectors based on reducible polycations facilitate intracellular release of nucleic acids
Read, M. L., Bremner, K. H., Oupický, D., Green, N. K., Searle, P. F., & Seymour, L. W. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.331 · Cited by 149
Inhibition of protein kinase C by cationic amphiphiles
Bottega, R., & Epand, R. M. (1992) · Biochemistry · doi:10.1021/bi00152a045 · Cited by 145
Preliminary Characterization of Novel Amino Acid Based Polymeric Vesicles as Gene and Drug Delivery Agents
Brown, M. D., Schätzlein, A. G., Brownlie, A., Jack, V., Wang, W., Tetley, L., GRAY, A. I., & Uchegbu, I. F. (2000) · Bioconjugate Chemistry · doi:10.1021/bc000052d · Cited by 141
Targeted Delivery of Plasmid DNA to Hepatocytes In Vivo: Optimization of the Pharmacokinetics of Plasmid DNA/Galactosylated Poly(l-Lysine) Complexes by Controlling their Physicochemical Properties
Nishikawa, M., Takemura, S., Takakura, Y., & Hashida, M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37804-8 · Cited by 135
Poly(ethylenimine-co- l -lactamide-co-succinamide): A Biodegradable Polyethylenimine Derivative with an Advantageous pH-Dependent Hydrolytic Degradation for Gene Delivery
Petersen, H., Merdan, T., Kunath, K., Fischer, D., & Kissel, T. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0255135 · Cited by 128
Cation Substitution in Cationic Phosphonolipids: A New Concept To Improve Transfection Activity and Decrease Cellular Toxicity
Floch, V., Loisel, S., Guénin, E., Hervé, A.-C., Clement, J. C., Yaouanc, J., Abbayes, H. D., & Férec, C. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000006z · Cited by 123
Cationic Polysaccharides for Gene Delivery
Azzam, T., Raskin, A., Makovitzki, A., Brem, H., Vierling, P., Lineal, M., & Domb, A. J. (2002) · Macromolecules · doi:10.1021/ma0209592 · Cited by 113
Water insoluble and soluble lipids for gene delivery
Mahato, R. I. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.005 · Cited by 101
Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo
Ward, C. M., Pechar, M., Oupický, D., Ulbrich, K., & Seymour, L. W. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.296 · Cited by 100
New Cationic Liposomes for Gene Transfer into Mammalian Cells with High Efficiency and Low Toxicity
Choi, J. S., Lee, E. J., Jang, H. S., & Park, J. S. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000081o · Cited by 99
Soluble Biodegradable Polymer-Based Cytokine Gene Delivery for Cancer Treatment
Maheshwari, A., Mahato, R. I., McGregor, J., Han, S., Samlowski, W. E., Park, J. S., & Kim, S. W. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0105 · Cited by 93
Efficacy of dendrimer‐mediated angiostatin and TIMP‐2 gene delivery on inhibition of tumor growth and angiogenesis: In vitro and in vivo studies
Vincent, L., Varet, J., Pille, J., Bompais, H., Opolon, P., Maksimenko, A., Malvy, C., Mirshahi, M., Lu, H., Vannier, J., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11105 · Cited by 88
Polymer Side-Chain Degradation as a Tool to Control the Destabilization of Polyplexes
Funhoff, A. M., van Nostrum, C. F., Janssen, A. P. C. A., Fens, M. H. A. M., Crommelin, D. J. A., & Hennink, W. E. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000012165.68765.e6 · Cited by 86
Handbook of Toxicology
Derelanko, M. J., & Hollinger, M. A. (2001) · CRC Press eBooks · doi:10.1201/9781420042078 · Cited by 84
Novel dextran–spermine conjugates as transfecting agents: comparing water-soluble and micellar polymers
Eliyahu, H., Makovitzki, A., Azzam, T., Zlotkin, A., Joseph, A. Z., Gazit, D., Barenholz, Y., & Domb, A. J. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302395 · Cited by 79
Gene medicines: The end of the beginning?
Rolland, A. P. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.002 · Cited by 79
Vehicles for oligonucleotide delivery to tumours
Dass, C. R. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021771887 · Cited by 78
A Novel Tetraester Construct That Reduces Cationic Lipid-Associated Cytotoxicity. Implications for the Onset of Cytotoxicity
Aberle, A. M., Tablin, F., Zhu, J. H., Walker, N. J., Gruenert, D. C., & Nantz, M. H. (1998) · Biochemistry · doi:10.1021/bi9801154 · Cited by 77
Synthesis of a novel series of cationic lipids that can act as efficient gene delivery vehicles through systematic heterocyclic substitution of cholesterol derivatives
Gao, H., & Hui, K. M. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301471 · Cited by 74
Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors
Funhoff, A. M., van Nostrum, C. F., Lok, M. C., Kruijtzer, J. A. W., Crommelin, D. J. A., & Hennink, W. E. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.023 · Cited by 72
Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener
Ilies, M. A., Johnson, B. H., Makori, F., Miller, A. L., Seitz, W. A., Thompson, E. B., & Balaban, A. T. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.12.010 · Cited by 71
Synthesis of a single-tailed cationic lipid and investigation of its transfection
Tang, F., & Hughes, J. A. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00158-3 · Cited by 70
Biophysical and biochemical properties of a binary lipid mixture for DNA transfection
Mirska, D., Schirmer, K., Funari, S. S., Langner, A., Dobner, B., & Brezesinski, G. (2004) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.10.007 · Cited by 67
Synthesis of acid-labile diplasmenyl lipids for drug and gene delivery applications
Boomer, J. A., & Thompson, D. H. (1999) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(99)00033-x · Cited by 65
Peptide-based gene delivery.
Ri, M., Od, M., Lc, S., & Rolland, A. P. (1999) · PubMed · Cited by 64
Biochemical and biophysical characteristics of lipoplexes pertinent to solid tumour gene therapy
Dass, C. R. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00194-1 · Cited by 61
A NONVIRAL VECTOR SYSTEM FOR EFFICIENT GENE TRANSFER TO CORNEAL ENDOTHELIAL CELLS VIA MEMBRANE INTEGRINS1
Shewring, L., Collins, L., Lightman, S., Hart, S. L., Gustafsson, K. T., & Fabre, J. W. (1997) · Transplantation · doi:10.1097/00007890-199709150-00018 · Cited by 60
Formation of Plasmid-Based Transfection Complexes with an Acid-Labile Cationic Lipid: Characterization of in Vitro and in Vivo Gene Transfer
Boomer, J. A., Thompson, D. H., & Sullivan, S. M. (2002) · Pharmaceutical Research · doi:10.1023/a:1020342523694 · Cited by 54
A hydroxyethylated cholesterol-based cationic lipid for DNA delivery: effect of conditioning
Percot, A., Briane, D., Coudert, R., Reynier, P., Bouchemal, N., Lievre, N., Hantz, E., Salzmann, J. L., & Cao, A. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.03.003 · Cited by 53
Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity
Maheshwari, A., Han, S.-Y., Mahato, R., & Kim, S. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301766 · Cited by 53
Quaternary Ammonium Polysaccharides for Gene Delivery
Yudovin-Farber, I., Yanay, C., Azzam, T., Michal Linial, B., & Domb, A. J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050066p · Cited by 51
Gene delivery systems—gene therapy vectors for cystic fibrosis
Klink, D. T., Schindelhauer, D., Laner, A., Tucker, T. A., Bebok, Z. M., Schwiebert, E. M., Boyd, A., & Scholte, B. J. (2004) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2004.05.042 · Cited by 49
Solid‐Phase Synthesis of 89 Polyamine‐Based Cationic Lipids for DNA Delivery to Mammalian Cells
Yingyongnarongkul, B., Howarth, M. R., Elliott, T. J., & Bradley, M. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200305232 · Cited by 46
Synthesis of carbamate-linked lipids for gene delivery
Liu, D., Hu, J., Qiao, W., Li, Z., Zhang, S., & Cheng, L. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.04.010 · Cited by 45
Self-citation
Pyridinium‐Based Cationic Lipids as Gene‐Transfer Agents
Ilies, M. A., Seitz, W. A., Căproiu, M. T., Wentz, M. J., Garfield, R. E., & Balaban, A. T. (2003) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300106 · Cited by 42
Dextran–spermine-based polyplexes—Evaluation of transgene expression and of local and systemic toxicity in mice
Eliyahu, H., Joseph, A., Azzam, T., Barenholz, Y., & Domb, A. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.024 · Cited by 37
Synthesis and characterization of a series of carbamate‐linked cationic lipids for gene delivery
Liu, D., Hu, I., Qiao, W., Li, Z., Zhan, S., & Cheng, L. (2005) · Lipids · doi:10.1007/s11745-005-1446-5 · Cited by 34
Common co‐lipids, in synergy, impart high gene transfer properties to transfection‐incompetent cationic lipids
Mukherjee, K., Sen, J., & Chaudhuri, A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.11.116 · Cited by 30
Toxicity of Cationic Lipid–Ribozyme Complexes in Human Prostate Tumor Cells Can Mimic Ribozyme Activity
Freedland, S. J., Malone, R. W., Borchers, H. M., Zadourian, Z., Glasspool‐Malone, J., Bennett, M. J., Nantz, M. H., Li, J.-H., Gumerlock, P. H., & Erickson, K. L. (1996) · Biochemical and Molecular Medicine · doi:10.1006/bmme.1996.0080 · Cited by 26
New Strategies for an Efficient Removal of the 9-Fluorenylmethoxycarbonyl (Fmoc) Protecting Group in the Peptide Synthesis
Leggio, A., Liguori, A., Napoli, A., Siciliano, C., & Sindona, G. (2000) · European Journal of Organic Chemistry · doi:10.1002/(sici)1099-0690(200002)2000:4 · Cited by 25
Introduction to cancer gene therapy
Cusack, J. C., & Tanabe, K. K. (2002) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(02)00029-7 · Cited by 25
Transfection by Polyethyleneimine-Coated Microspheres
Manuel, W. S., Zheng, J. Y., & Hornsby, P. J. (2001) · Journal of drug targeting · doi:10.3109/10611860108995629 · Cited by 25
Synthesis of bifunctional cationic compound for gene delivery
Ren, T., Zhang, G., & Liu, D. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)02221-8 · Cited by 24
Effect of oligopeptides on gene expression: comparison of DNA/peptide and DNA/peptide/liposome complexes
Tokunaga, M., Hazemoto, N., & Yotsuyanagi, T. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.08.018 · Cited by 22
A comparative study of different cationic transfection agents for in vivo gene delivery after intravenous administration
Verbaan, F. J., Bos, G. W., Oussoren, C., Woodle, M. C., Hennink, W. E., & Storm, G. (2004) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(04)50021-7 · Cited by 22
Amphiphilic detergents inhibit production of IgG and IgM by human peripheral blood mononuclear cells
Jahnova, E., Ferencĭk, M., Nyulassy, Š., Devı́nsky, F., & Lacko, I. (1993) · Immunology Letters · doi:10.1016/0165-2478(93)90166-y · Cited by 17
Immunomodulatory activity of some amphiphilic compounds.
Ferencĭk, M., Lacko, I., & Devı́nsky, F. (1990) · PubMed · Cited by 17
Synthesis of the First Axially Dissymmetric,Cα,α-Disubstituted Glycine Containing a Crown Ether Receptor, and the Conformational Preferences of a Model Peptide
Mazaleyrat, J., Goubard, Y., Azzini, M.-V., Wakselman, M., Peggion, C., Formaggio, F., & Toniolo, C. (2002) · European Journal of Organic Chemistry · doi:10.1002/1099-0690(200204)2002:7 · Cited by 15

Research works printed but not linked: 1

Hong, 1997, Stabilisation of cationic liposome/DNA complexes by polyamines and polyethyleneglycol–phospholipid conjugates for efficient in vivo gene delivery, FEBS Lett., 414, 187

Sorted by citations

Lipid nanoparticles for mRNA delivery
Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Advances and Challenges of Liposome Assisted Drug Delivery
Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672
Delivery technologies for cancer immunotherapy
Riley, R., June, C. H., Langer, R., & Mitchell, M. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0006-z · Cited by 2,678

See all 2,286

Authors: Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J.
Affiliations: Dalian Institute of Chemical Physics (CN)
Dalian Minzu University (CN)
Sichuan University of Science and Engineering (CN)
Corresponding author: Zhang, Shubiao
ORCID: Zhang, Shubiao
Wang, Bing
Yan, Jie
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2006-08
Volume: 114
Issue: 1
Pages: 100-109
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2006.04.014
OpenAlex: W2000136129
Cited by: 2,286
References: 107
Citations by year: 2026: 100 · 2025: 123 · 2024: 163 · 2023: 141 · 2022: 146 · 2021: 149 · 2020: 140 · 2019: 168 · 2018: 129 · 2017: 133 · 2016: 124 · 2015: 126 · 2014: 147 · 2013: 117 · 2012: 97
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: cationic lipids, cationic polymers, gene delivery, non-viral vectors, toxicity, structure-toxicity relationship, gene therapy, cationic compounds
MeSH terms: Animals, Cations, Lipids, Liposomes, Polylysine, Polymers, Polysaccharides, Genetic Therapy, Molecular Structure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Toxicity of cationic lipids and cationic polymers in gene delivery

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks