Cited by 2,286RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryVirus-based gene therapy research

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Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, Hongtao, Zhang, Shubiao, Wang, Bing, Cui, Shaohui, Yan, Jie·2006·Journal of Controlled Release

DOI 10.1016/j.jconrel.2006.04.014

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Abstract

Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds.

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Authors: Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J.
Affiliations: Dalian Institute of Chemical Physics (CN)
Dalian Minzu University (CN)
Sichuan University of Science and Engineering (CN)
Corresponding author: Zhang, Shubiao
ORCID: Zhang, Shubiao
Wang, Bing
Yan, Jie
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2006-08
Volume: 114
Issue: 1
Pages: 100-109
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2006.04.014
OpenAlex: W2000136129
Cited by: 2,286
References: 107
Citations by year: 2026: 100 · 2025: 123 · 2024: 163 · 2023: 141 · 2022: 146 · 2021: 149 · 2020: 140 · 2019: 168 · 2018: 129 · 2017: 133 · 2016: 124 · 2015: 126 · 2014: 147 · 2013: 117 · 2012: 97
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: cationic lipids, cationic polymers, gene delivery, non-viral vectors, toxicity, structure-toxicity relationship, gene therapy, cationic compounds
MeSH terms: Animals, Cations, Lipids, Liposomes, Polylysine, Polymers, Polysaccharides, Genetic Therapy, Molecular Structure

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Toxicity of cationic lipids and cationic polymers in gene delivery

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