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Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
Abstract
Elastin-like polymers are a new type of protein-based polymers that display interesting properties in the biomaterial field. Bone morphogenetic proteins (BMPs) are cytokines with a strong ability to promote new bone formation. In this work, we explored the use of elastin-like nanoparticles (average size 237.5+/-3.0 nm), created by thermoresponsive self-assembly, for the combined release of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-14 (BMP-14). These BMPs could be encapsulated at high efficiency into the elastin-like particles and delivered in a sustained way for 14 days. The activity of the growth factors was retained, as shown by the induction of ALP activity and osteogenic mineralization in C2C12 cells. Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone.
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Cited by
Biomedical applications of biodegradable polymers
Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011) · Journal of Polymer Science Part B: Polymer Physics · doi:10.1002/polb.22259 · Cited by 2,206
Thermoresponsive Polymers for Biomedical Applications
Ward, M. A., & Georgiou, T. K. (2011) · Polymers · doi:10.3390/polym3031215 · Cited by 1,158
Protein-based nanocarriers as promising drug and gene delivery systems
Elzoghby, A. O., Samy, W. M., & Elgindy, N. A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.036 · Cited by 852
Strategies for controlled delivery of growth factors and cells for bone regeneration
Vo, T. N., Kasper, F. K., & Mikos, A. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.016 · Cited by 666
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
De Witte, T.-M., Fratila-Apachitei, L. E., Zadpoor, A. A., & Peppas, N. A. (2018) · Regenerative Biomaterials · doi:10.1093/rb/rby013 · Cited by 513
Metadata
- Authors
- Bessa, P. C., Machado, R., Nürnberger, S., Dopler, D., Banerjee, A., Cunha, A. M., Rodríguez-Cabello, J. C., Redl, H., van Griensven, M., Reis, R. L., & Casal, M.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 142
- Issue
- 3
- Pages
- 312-318
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2055000650
- Cited by
- 186
- References
- 0
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bessa, P. C., Machado, R., Nürnberger, S., Dopler, D., Banerjee, A., Cunha, A. M., Rodríguez-Cabello, J. C., Redl, H., van Griensven, M., Reis, R. L., & Casal, M. (2010). Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2009.11.003
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