The DOI matches its Crossref record; 155 of the 159 references it cites were found in a registry or an index.
Drug nanocrystals: in vivo performances.
Abstract
Over the past few decades, there has been a considerable research interest in drug nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning lots of works have been done to study various technologies associated with production of drug nanocrystals and their in vitro physical and chemical properties, such as morphology, formulation composition, stabilities, crystalline structure and enhanced solubility and dissolution velocity. Recently, in vivo behaviors of the nanocrystals have been generally studied in animals (including human), and the results proved that drug nanocrystals could be used as a versatile formulation to alter and improve the pharmacokinetic, pharmacodynamic and targeting properties of poorly soluble drugs. In this paper, in vivo performances of drug nanocrystals exhibited in animals in different administration route were reviewed, and the advantages of drug nanocrystals in the aspect of safety, pharmacodynamics, pharmacokinetics and targeting delivery were discussed in detail.
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“Various nanodrug system such as polymers, micelles, liposomes, dendrimers, nanocrystals, SLNPs have been used to improve efficacy, safety physiological properties pharmacokinetics, and pharmacodynamics of drugs (Figure 2) (Shegokar and Müller, 2010; Chan and Kwok, 2011; Gao et al., 2012; Thomas et al., 2013).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Gao et al., 2012
Citations
Cites
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,781
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
Nanoparticles in cancer therapy and diagnosis
Brigger, I., Dubernet, C., & Couvreur, P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00044-3 · Cited by 3,040
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029
Nanosuspensions in drug delivery
Rabinow, B. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1494 · Cited by 1,529
Targeted drug delivery via the folate receptor
Sudimack, J. J., & Lee, R. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00062-9 · Cited by 1,477
Nanosuspensions as particulate drug formulations in therapy
Müller, R. H., Jacobs, C., & Kayser, O. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00118-6 · Cited by 1,370
Inhaling medicines: delivering drugs to the body through the lungs
Patton, J. S., & Byron, P. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2153 · Cited by 1,370
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Nanosizing: a formulation approach for poorly-water-soluble compounds
Merisko-Liversidge, E. M., Liversidge, G. G., & Cooper, E. R. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00251-8 · Cited by 1,270
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4 of the 159 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Lipinski, 2002, Poor aqueous solubility — an industry wide problem in drug discovery, Am. Pharm. Rev., 5, 82
- des Rieux, 2006, Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach, J. Control. Release, 116, 1, 10.1016/j.jconrel.2006.08.013 · DOI · Paper page
- Dressman, 2000, In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs, Eur. J. Pharm. Sci., 11, S73, 10.1016/S0928-0987(00)00181-0 · DOI
- Clement, 1992, Tissue distribution and plasma clearance of a novel microcrystalline-coated flurbiprofen formulation, Pharmacologist, 34, 204
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Chandrakala, V., Aruna, V., & Angajala, G. (2022) · Emergent Materials · doi:10.1007/s42247-021-00335-x · Cited by 768
Facing the Truth about Nanotechnology in Drug Delivery
Park, K. (2013) · ACS Nano · doi:10.1021/nn404501g · Cited by 555
Drug self-delivery systems for cancer therapy
Qin, S.-Y., Zhang, A.-Q., Cheng, S.-X., Rong, L., & Zhang, X.-Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.016 · Cited by 532
Stability of nanosuspensions in drug delivery
Wang, Y., Zheng, Y., Zhang, L., Wang, Q., & Zhang, D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.006 · Cited by 493
Nanodrugs: pharmacokinetics and safety
Onoue, S., Yamada, S., & Chan, H. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s38378 · Cited by 383
Metadata
- Authors
- Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X.
- Affiliations
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Corresponding author
- Gao, Lei
- Liu, Guiyang
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 160
- Issue
- 3
- Pages
- 418-430
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2041317416
- Cited by
- 347
- References
- 159
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 20 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 36 · 2019: 26 · 2018: 27 · 2017: 28 · 2016: 36 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- drug nanocrystals, poorly water-soluble drugs, pharmacokinetics, pharmacodynamics, targeted drug delivery, in vivo performance, route of administration, dissolution enhancement
- MeSH terms
- Animals, Drug Administration Routes, Pharmaceutical Preparations, Humans, Pharmacokinetics, Drug Delivery Systems, Nanoparticles
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