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Drug nanocrystals: in vivo performances.
Abstract
Over the past few decades, there has been a considerable research interest in drug nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning lots of works have been done to study various technologies associated with production of drug nanocrystals and their in vitro physical and chemical properties, such as morphology, formulation composition, stabilities, crystalline structure and enhanced solubility and dissolution velocity. Recently, in vivo behaviors of the nanocrystals have been generally studied in animals (including human), and the results proved that drug nanocrystals could be used as a versatile formulation to alter and improve the pharmacokinetic, pharmacodynamic and targeting properties of poorly soluble drugs. In this paper, in vivo performances of drug nanocrystals exhibited in animals in different administration route were reviewed, and the advantages of drug nanocrystals in the aspect of safety, pharmacodynamics, pharmacokinetics and targeting delivery were discussed in detail.
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“Various nanodrug system such as polymers, micelles, liposomes, dendrimers, nanocrystals, SLNPs have been used to improve efficacy, safety physiological properties pharmacokinetics, and pharmacodynamics of drugs (Figure 2) (Shegokar and Müller, 2010; Chan and Kwok, 2011; Gao et al., 2012; Thomas et al., 2013).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Gao et al., 2012
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Metadata
- Authors
- Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X.
- Affiliations
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Corresponding author
- Gao, Lei
- Liu, Guiyang
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 160
- Issue
- 3
- Pages
- 418-430
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2041317416
- Cited by
- 347
- References
- 159
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 20 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 36 · 2019: 26 · 2018: 27 · 2017: 28 · 2016: 36 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- drug nanocrystals, poorly water-soluble drugs, pharmacokinetics, pharmacodynamics, targeted drug delivery, in vivo performance, route of administration, dissolution enhancement
- MeSH terms
- Animals, Drug Administration Routes, Pharmaceutical Preparations, Humans, Pharmacokinetics, Drug Delivery Systems, Nanoparticles
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